All Publications
All Publications
[Square brackets indicate peer-reviewed publications]
Note that some reprints are available in pdf format by clicking on the linked number of the reprint.
Furthermore, some of the references are linked to the publication source.
1. ELIOT, C.R., KAJI, A., SEEMAN, P., UBELL, E., KUFFLER, S.W. and BURGEN, A.S.V.:
The effect of nervous system extracts on inhibition and excitation to single nerve cells. Biol.
Bull. 113: 344 (1957).
2. BURGEN, A.S.V. and SEEMAN, P.: Partial equilibration in the ducts as a factor
determining saliva composition. Can. Physiol. Soc. Abstr. 20: 12 (1956).
3.[1]. BURGEN, A.S.V. and SEEMAN, P.: The role of the salivary duct system in the formation
of the saliva. Can. J. Biochem. Physiol. 36: 119-143 (1958).
4.[2]. SEEMAN, P. and O'BRIEN, E.: Sodium-potassium-activated adenosine triphosphatase in
schizophrenic erythrocytes. Nature 200: 263-264 (1963).
5. BURGEN, A.S.V. and SEEMAN, P.: The interstitial diffusion of small molecules in the
salivary gland of the dog. 20th Int. Congr. Physiol. Abstr. (Brussels), 305 (1956).
6.[3]. SEEMAN, P. and BIALY, H.S.: The surface activity of tranquilizers. Biochem. Pharmacol.
12: 1181-1191 (1963).
7.[4]. BURGEN, A.S.V. and SEEMAN, P.: The secretion of iodide in saliva. Can. J. Biochem.
Physiol. 35: 481-489 (1957).
8.[5]. SEEMAN, P.: Erythrocyte membrane stabilization by steroids and alcohols: A possible
model for anesthesia. Biochem. Pharmacol. 15: 1632-1637 (1966).
9.[6]. SEEMAN, P.: A method for distinguishing specific from nonspecific hemolysins. Biochem.
Pharmacol. 15: 1767-1774 (1966).
10.[7]. SEEMAN, P.: Erythrocyte membrane stabilization by local anesthetics and tranquilizers.
Biochem. Pharmacol. 15: 1753-1766 (1966).
11.[8]. SEEMAN, P., and WEINSTEIN, J.: Erythrocyte membrane stabilization by tranquilizers and
anti-histamines. Biochem. Pharmacol. 15: 1737-1752 (1966).
12.[9]. SEEMAN, P.: Membrane stabilization by drugs: Tranquilizers, steroids and anesthetics. Int.
Rev. Neurobiol. 9: 145-221 (1966).
13.[10]. SEEMAN, P.: Transient holes in the erythrocyte membrane during hypotonic hemolysis and
stable holes in the membrane after lysis by saponin and lysolecithin. J. Cell Biol. 32: 55-70
(1967).
14.[11]. SEEMAN, P., and PALADE, G.E.: Acid phosphatase localization in rabbit eosinophils. J.
Cell Biol. 34: 745-756 (1967).
15. SEEMAN, P.: Subcellular membrane-drug interactions. In: The interaction of drugs and
subcellular components in animal cells, edited by P.N. Campbell , J. & A. Churchill Ltd.,
London, 212-213 (1968).
16.[12]. METCALFE, J., SEEMAN, P., and BURGEN, A.S.V.: The proton relaxation of benzyl
alcohol in erythrocyte membranes. Mol. Pharmacol. 4: 87-95 (1968).
17.[13]. SEEMAN, P.: Membrane stabilization and expansion by drugs. In: Metabolism and
membrane permeability of erythrocytes and thrombocytes, edited by E. Deutsch, E. Gerlach
and K. Moser, Georg Thieme Verlag, Stuttgart, 384-391 (1968).
1. ELIOT, C.R., KAJI, A., SEEMAN, P., UBELL, E., KUFFLER, S.W. and BURGEN, A.S.V.:
The effect of nervous system extracts on inhibition and excitation to single nerve cells. Biol.
Bull. 113: 344 (1957).
2. BURGEN, A.S.V. and SEEMAN, P.: Partial equilibration in the ducts as a factor
determining saliva composition. Can. Physiol. Soc. Abstr. 20: 12 (1956).
3.[1]. BURGEN, A.S.V. and SEEMAN, P.: The role of the salivary duct system in the formation
of the saliva. Can. J. Biochem. Physiol. 36: 119-143 (1958).
4.[2]. SEEMAN, P. and O'BRIEN, E.: Sodium-potassium-activated adenosine triphosphatase in
schizophrenic erythrocytes. Nature 200: 263-264 (1963).
5. BURGEN, A.S.V. and SEEMAN, P.: The interstitial diffusion of small molecules in the
salivary gland of the dog. 20th Int. Congr. Physiol. Abstr. (Brussels), 305 (1956).
6.[3]. SEEMAN, P. and BIALY, H.S.: The surface activity of tranquilizers. Biochem. Pharmacol.
12: 1181-1191 (1963).
7.[4]. BURGEN, A.S.V. and SEEMAN, P.: The secretion of iodide in saliva. Can. J. Biochem.
Physiol. 35: 481-489 (1957).
8.[5]. SEEMAN, P.: Erythrocyte membrane stabilization by steroids and alcohols: A possible
model for anesthesia. Biochem. Pharmacol. 15: 1632-1637 (1966).
9.[6]. SEEMAN, P.: A method for distinguishing specific from nonspecific hemolysins. Biochem.
Pharmacol. 15: 1767-1774 (1966).
10.[7]. SEEMAN, P.: Erythrocyte membrane stabilization by local anesthetics and tranquilizers.
Biochem. Pharmacol. 15: 1753-1766 (1966).
11.[8]. SEEMAN, P., and WEINSTEIN, J.: Erythrocyte membrane stabilization by tranquilizers and
anti-histamines. Biochem. Pharmacol. 15: 1737-1752 (1966).
12.[9]. SEEMAN, P.: Membrane stabilization by drugs: Tranquilizers, steroids and anesthetics. Int.
Rev. Neurobiol. 9: 145-221 (1966).
13.[10]. SEEMAN, P.: Transient holes in the erythrocyte membrane during hypotonic hemolysis and
stable holes in the membrane after lysis by saponin and lysolecithin. J. Cell Biol. 32: 55-70
(1967).
14.[11]. SEEMAN, P., and PALADE, G.E.: Acid phosphatase localization in rabbit eosinophils. J.
Cell Biol. 34: 745-756 (1967).
15. SEEMAN, P.: Subcellular membrane-drug interactions. In: The interaction of drugs and
subcellular components in animal cells, edited by P.N. Campbell , J. & A. Churchill Ltd.,
London, 212-213 (1968).
16.[12]. METCALFE, J., SEEMAN, P., and BURGEN, A.S.V.: The proton relaxation of benzyl
alcohol in erythrocyte membranes. Mol. Pharmacol. 4: 87-95 (1968).
17.[13]. SEEMAN, P.: Membrane stabilization and expansion by drugs. In: Metabolism and
membrane permeability of erythrocytes and thrombocytes, edited by E. Deutsch, E. Gerlach
and K. Moser, Georg Thieme Verlag, Stuttgart, 384-391 (1968).
18.[14]. SEEMAN, P.: Membrane expansion and stabilization by anesthetics and other drugs. In:
Permeability and function of biological membranes, edited by R.D. Keynes, W.R.
Loewenstein and B.A. Pethica, North-Holland, New York, 1970, pp. 40-56.
19.[15]. SEEMAN, P., SAUKS, T., ARGENT, W. and KWANT, W.: The effect of membrane strain-
rate and of temperature on erythrocyte fragility and critical hemolytic volume. Biochim.
Biophys. Acta 183: 476-489 (1969).
20.[16]. SEEMAN, P., KWANT, W.O., SAUKS, T. and ARGENT, W.: Membrane expansion of
intact erythrocytes by anesthetics. Biochim. Biophys. Acta 183: 490-498 (1969).
21.[17]. SEEMAN, P., KWANT, W.O. and SAUKS, T. : Membrane expansion of erythrocyte ghosts
by tranquilizers and anesthetics. Biochim. Biophys. Acta 183: 499-511 (1969).
22.[18]. SEEMAN, P., and KWANT, W.O.: Membrane expansion of the erythrocyte by both the
neutral and ionized forms of chlorpromazine. Biochim. Biophys. Acta 183: 512-519 (1969).
23.[19]. SEEMAN, P.: Temperature dependence of erythrocyte membrane expansion by alcohol
anesthetics. Possible support for the partition theory of anesthesia. Biochem. Biophys. Acta
183: 520-529 (1969).
24.[20]. KWANT, W.O., and SEEMAN, P.: The membrane concentration of a local anesthetic
(chlorpromazine). Biochim. Biophys. Acta 183: 530-543 (1969).
25. ROTH, S., and SEEMAN, P.: The membrane concentration of anesthetics, and the
hydrophobic bond of the anesthetic-membrane interaction. Can. Fed. Biol. Soc. Abstr.12: 19
(1969).
26. THORPE, W.R., and SEEMAN, P.: Change in calcium binding of sarcolemma after
denervation. Can. Fed. Biol. Soc. Abstr. 13: 353 (1970).
27. CHAU, M., and SEEMAN, P.: Membrane calcium is increased by anesthetics of low
molecular weight; a possible explanation for the anesthetic-induced sensitization of nerve and
muscle cells. Can. Fed. Biol. Soc. Abstr. 13: 433 (1970).
28. SEEMAN, P., and ROTH, S.: Membrane expansion by anesthetics. The hydrophobic nature
of the membrane-anesthetic bond. 4th Int. Congr. Pharmacol. Abstr. (Basel), 1969, p. 328,
Schwabe & Co., Basel.
29. SEEMAN, P., CHAU, M., KWANT, W. and ROTH, S.: The expansion and vesiculation of
membranes, and the displacement of membrane-bound calcium ions and ATP, by local
anesthetics. 3rd Int. Biophys. Congr. Abstr., 81 (1969).
30. SEEMAN, P., CHAU-WONG, M., SAUKS, T., GOLDBERG, M. and SAX, L.: Membrane
calcium is increased by anesthetics of low molecular weight and decreased by adenosine
triphosphate; a possible explanation for the anesthetic-induced sensitization of nerve and
muscle cells. Fed. Proc. 29: 548A (1970).
31.[21]. KWANT, W.O. and SEEMAN, P.: The erythrocyte ghost is a perfect osmometer. J. Gen.
Physiol. 55: 208-219 (1970).
32. KWANT, W., ROTH, S. and SEEMAN, P.: The binding of chlorpromazine and alcohol
anesthetics to membranes. Fed. Proc. 24: 614 (1969).
33.[22]. KWANT, W.O. and SEEMAN, P.: The displacement of membrane calcium by a local
anesthetic (chlorpromazine). Biochim. Biophys. Acta 193: 338-349 (1969).
34.[23]. BRAUN, W., ISHIZUKA, M. and SEEMAN, P.: Suppression and enhancement of antibody
formation by alteration of Ca2+ levels. Nature 226: 945-946 (1970).
35.[24]. SEEMAN, P.: The membrane expansion theory of anesthesia. In: Molecular mechanisms of
anesthesia, edited by B.R. Fink, Raven Press, New York, 243-251 (1975).
36.[25]. MACLENNAN, D.H., SEEMAN, P., ILES, G.H. and YIP, C.C.: Membrane formation by
the adenosine triphosphatase of sarcoplasmic reticulum. J. Biol. Chem. 246: 2702-2710
(1971).
37.[26]. SEEMAN, P., SHA'AFI, R., GALEY, W.R. and SOLOMON, A.K.: The effect of anesthetics
(chlorpromazine, ethanol) on erythrocyte permeability to water. Biochim. Biophys. Acta 211:
365-368 (1970).
38.[27]. SEEMAN, P., ROTH, S. and SCHNEIDER, H.: The membrane concentrations of alcohol
anesthetics. Biochim. Biophys. Acta 225: 171-184 (1971).
39.[28]. SEEMAN, P., CHAU, M., GOLDBERG, M., SAUKS, T. and SAX, L.: The binding of Ca2+
to the cell membrane increased by volatile anesthetics (alcohols, acetone, ether) which induce
sensitization of nerve or muscle. Biochim. Biophys. Acta 225: 185-193 (1971).
40.[29]. KWANT, W.O. and SEEMAN, P.: Chlorpromazine adsorption to brain regions. Biochem.
Pharmacol. 20: 2089-2091 (1971).
41.[30]. THORPE, W.R. and SEEMAN, P.: Effect of denervating skeletal muscle on calcium binding
by isolated sarcolemma. Exp. Neurol. 30: 277-290 (1971).
42.[31]. SEEMAN, P.,: Membrane anesthesia. In: Biological horizons in surface science, F. Sears
and L.M. Prince (Eds.), Academic Press, New York, 289-308 (1973).
43. SEEMAN, P. and ROTH, S.: General anesthetics expand membranes at surgical
concentrations. Can. Fed. Biol. Soc. Abstr. 14: 132 (1971).
44.[32]. ROTH, S. and SEEMAN, P.: All lipid-soluble anesthetics protect red cells. Nature 231:
284-285 (1971).
45.[33]. SEEMAN, P., KWANT, W.O., GOLDBERG, M. and CHAU-WONG, M.: The effects of
ethanol and chlorpromazine on the passive membrane permeability to sodium ions. Biochim.
Biophys. Acta 241: 349-355 (1971).
46. ROTH, S. and SEEMAN, P.: General anesthetics expand membranes at surgical
concentrations. Int. Congr. Physiol. Sci. Abstr., Munich (1971).
47.[34]. CHAU-WONG, M. and SEEMAN, P.: The control of membrane-bound calcium ions by
ATP. Biochim. Biophys. Acta 241: 473-482 (1971).
48.[35]. THORPE, W.R. and SEEMAN, P.: The site of action of caffeine and procaine in skeletal
muscle. J. Pharmacol. Exp. Ther. 179: 324-330 (1971).
49. SEEMAN, P. and ROTH, S.: General anesthetics expand membranes at surgical
concentrations. The Pharmacologist 13: 270 (1971).
50.[36]. SEEMAN, P.: The membrane actions of anesthetics and tranquilizers. Pharmacol. Rev. 24:
583-655 (1972).
51.[37]. MACHLEIDT, H., ROTH, S. and SEEMAN, P.: The hydrophobic expansion of erythrocyte
membranes by the phenol anesthetics. Biochim. Biophys. Acta 255: 178-189 (1972).
52.[38]. SEEMAN, P. and ROTH, S.: General anesthetics expand cell membranes at surgical
concentrations. Biochim. Biophys. Acta 255: 171-177 (1972).
53.[39]. ROTH, S. and SEEMAN, P., AKERMAN, S.B.A. and CHAU-WONG, M.: The action and
adsorption of local anesthetic enantiomers on erythrocyte and synaptosome membranes.
Biochim. Biophys. Acta 255: 199-206 (1972).
54.[40]. ROTH, S. and SEEMAN, P.: Anesthetics expand erythrocyte membranes without causing
loss of K+. Biochim. Biophys. Acta 255: 190-198 (1972).
55.[41]. ROTH, S. and SEEMAN, P.: The membrane concentrations of neutral and positive
anesthetics (alcohol, chlorpromazine, morphine) fit the Meyer-Overton rule of anesthesia;
negative narcotics do not. Biochim. Biophys. Acta 255: 207-219 (1972).
56.[42]. THORPE, W. and SEEMAN, P.: Drug-induced contracture of muscle. Int. Symp. on
Malignant Hyperthermia, edited by R.A. Gordon, B.A. Britt and W. Kalow, C.C. Thomas,
USA, 152-162 (1972).
57. ILES, G., SEEMAN, P., NAYLOR, D. and CINADER, B.: Freeze-etch electron microscopy
of membrane holes produced by complement. Biophys. Soc. Abstr. 16: 259a (1972).
58. SEEMAN, P.: The membrane concentrations of general and local anesthetics fit the Meyer-
Overton-Mullins rule of anesthesia. Fifth Int. Congr. Pharmacol. Abstr. 1239, p. 207 (1972).
59. SEEMAN, P., ILES, G., NAYLOR, D. and CINADER, B.: Membrane ultrastructure of
complement- and anesthetic-induced lesions. Can. Fed. Biol. Soc. Abstr. 15: 758 (1972).
60. ILES, G.H., COBBOLD, R.S.C. and SEEMAN, P.: Technical aspects of the freeze-fracture
method of ultrastructure examination of cellular membranes. Can. Med. Biol. Eng. Soc. 4:
(1972).
61.[43]. MACLENNAN, D.H.,ILES, G.H., YIP, C.C. and SEEMAN, P.: Isolation of sarcoplasmic
reticulum proteins. Cold Spring Harbour Symp. 37: 469-477 (1973).
62.[44]. SEEMAN, P.: Membrane ultrastructure of complement-induced lesions. In: Recent physical
studies of the structure of biomembranes, edited by D. Chapman; and In: Chem. Phys. Lipids
8: 270-277 (1972).
63.[45]. SEEMAN, P.: Drug-induced expansion of biomembranes. In: Recent physical studies of
structure of biomembranes, edited by D. Chapman; and In: Chem. Phys. Lipids 8: 361-365
(1972).
64. SEEMAN, P.: The membrane actions of the excitability-controlling drugs. Neurosci. Soc.
Abstr. 2: 238 (1972).
65.[46]. THORPE, W.R. and SEEMAN, P.: On the mechanism of the nicotine-induced contracture of
skeletal muscle. Can. J. Physiol. Pharmacol. 50: 920-923 (1972).
66.[47]. SEEMAN, P., CHAU-WONG, M. and MOYYEN, S.: Membrane expansion by vinblastine
and strychnine. Nature 241: 22 (1973).
67.[48]. SEEMAN, P.: Macromolecules may inhibit diffusion of hemoglobin from lysing
erythrocytes by exclusion of solvent. Can. J. Physiol. Pharmacol. 51: 226-229 (1973).
68.[49]. SEEMAN, P. and ILES, G.H.: Pits in the freeze-cleavage plane of normal erythrocyte
membranes; and ultrastructure of membrane lesions in immune lysis. Nouv. Rev. Fr.
d'Hematol. 12: 889-900 (1972).
69.[50]. SEEMAN, P., CHENG, D. and ILES, G.H.: Structure of membrane holes in osmotic and
saponin hemolysis. J. Cell Biol. 56: 519-527 (1973).
70.[51]. ILES, G.H., SEEMAN, P., NAYLOR, D. and CINADER, B.: Membrane lesions in immune
lysis: Surface rings, globule aggregates and transient openings. J. Cell Biol. 56: 528-539
(1973).
71.[52]. SEEMAN, P., CHAU-WONG, M. and MOYYEN, S.: Adsorption and conduction-block of
opiate narcotics on nerve membranes: identical effects of levo- and dextro-forms. Can. J.
Physiol. Pharmacol. 50: 1181-1192 (1972).
72.[53]. SEEMAN, P., CHAU-WONG, M. and MOYYEN, S.: Membrane binding of morphine,
diphenylhydantoin and tetrahydrocannabinol. Can. J. Physiol. Pharmacol. 50: 1193-1200
(1972).
73.[54]. SEEMAN, P.: The pH concept. Science 177: 835-836 (1972).
74. SEEMAN, P.: The erythrocyte as a model for studying membrane stabilization by
tranquilizers, anesthetics, and steroids. Diss. Abstr. 28 (No. 3), 1966, University Microfilms,
Ann Arbor.
75. SEEMAN, P., STAIMAN, A. and CHAU-WONG, M.: Neurone-blocking actions of
antipsychotic drugs. Fed. Proc. 32: 248 (1973).
76.[55]. SEEMAN, P.: The molecular basis of fluidity in membranes. In: Recent physical studies of
structure of biomembranes, edited by D. Chapman, 1972, North-Holland, Amsterdam; and In:
Chem. Phys. Lipids 8: 311-313 (1972).
77.[56]. NAFTALIN, R.J., SEEMAN, P., SIMMONS, N.L. and SYMONS, M.C.R.: A sugar-
dependent increase in red cell stability. Biochim. Biophys. Acta 352: 146-171 (1974).
78. SEEMAN, P., STAIMAN, A. and CHAU-WONG, M.: The neurone-blocking actions of
antipsychotic drugs. Can. Fed. Biol. Soc. Abstr. 16: 7 (1973).
79.[57]. SEEMAN, P. : Teach cH, not pH. Biochem. Educ. Quart. Bull. Int. Union Biochem. 1(3):
44-47 (1973).
80.[58]. SEEMAN, P. and ILES, G.H.: Pits in the freeze-cleavage plane of normal erythrocyte
membranes; and ultrastructure of membrane lesions in immune lysis. In: Red cell shape;
physiology, pathology, ultrastructure, edited by M. Bessis, R.I. Weed and P.F. Leblond,
Springer-Verlag, New York, pp. 169-180, 1973.
81.[59]. SEEMAN, P., STAIMAN, A., LEE, T. and CHAU-WONG, M. : The membrane actions of
tranquilizers in relation to neuroleptic-induced Parkinsonism and tardive dyskinesia. Adv.
Biochem. Psychopharmacol. 9: 137-148 (1974).
82.[60]. SEEMAN, P., STAIMAN, A. and CHAU-WONG, M.: The nerve impulse-blocking actions
of tranquilizers, and the binding of neuroleptics to synaptosome membranes. J. Pharmacol.
Exp. Ther. 190: 123-130 (1974).
83.[61]. SEEMAN, P. and LEE, T.: The dopamine-releasing actions of neuroleptics and ethanol. J.
Pharmacol. Exp. Ther. 190: 131-140 (1974).
84.[62]. STAIMAN, A. and SEEMAN, P.: The impulse-blocking concentrations of anesthetics,
alcohols, anti-convulsants, barbiturates and narcotics on phrenic and sciatic nerves. Can. J.
Physiol. Pharmacol. 52: 535-550 (1974).
85.[63]. MULLER, P., SEEMAN, P. and SPERO, L. : The additive effects of tranquilizers and
dopamine on smooth muscle. Can. J. Physiol. Pharmacol. 52: 551-557 (1974).
86.[64]. SEEMAN, P. and LEE, T.: Enhanced binding of chlorpromazine to cholesterol-depleted
nerve membranes. Can. J. Physiol. Pharmacol. 52: 522-525 (1974).
87.[65]. SEEMAN, P., MACHLEIDT, H., KAHLING, J. and SENGUPTA, S.: A new prolonged-
acting type of chlorpromazine: Behavioural effects and prolonged actions on nerve
membranes. Can. J. Physiol. Pharmacol. 52: 558-565 (1974).
88.[66]. SEEMAN, P., CHEN, S.S., CHAU-WONG, M. and STAIMAN, A.: Calcium reversal of
nerve blockade by alcohols, anesthetics, tranquilizers and barbiturates. Can. J. Physiol.
Pharmacol. 52: 526-534 (1974).
90. SEEMAN, P.: Comparison of presynaptic and postsynaptic theories of neuroleptic action. J.
Pharmacol. (Paris) 5, Suppl. 2: 91 (1974).
91. SEEMAN, P., WONG, M. and LEE, T.: Dopamine receptor-block and nigral fiber-impulse
blockade by major tranquilizers. Fed. Proc. 33: 246, Abstr. 243 (1974).
92. STAIMAN, A., SPERO, L. and SEEMAN, P.: Different sites of membrane action for
tetrodotoxin and lipid-soluble anesthetics. Can. Fed. Biol. Soc. Abstr. 17: 160 (1974).
93. LEE, T. and SEEMAN, P.: Tranquilizer-blockade of dopamine release from stimulated
striatal slices. Can. Fed. Biol. Soc. Abstr. 17: 57 (1974).
94. BARYSHNIK, S. and SEEMAN, P.: Neuroleptic action on cholinergic transmission. Can.
Fed. Biol. Soc. Abstr. 17: 57 (1974).
95. SEEMAN, P.: Ultrastructure of membrane lesions in immune lysis, osmotic lysis and drug-
induced lysis. Fed. Proc. 33: 2116-2124 (1974).
96.[67]. SEEMAN, P.: The membrane expansion theory of anesthesia: Direct evidence using ethanol
and a high-precision density meter. Experientia 30: 759-760 (1974).
97. SEEMAN, P. and LEE, T.: Tranquilizer-blockade of dopamine release from stimulated
striatal slices. Soc. Neurosci. Abstr. 4: 418 (1974).
98.[68]. SEEMAN, P.: The actions of nervous system drugs on cell membranes. Hosp. Practice 9(9):
93-101 (1974).
99. PRCHAL, J.T., BLAKELY, J. and SEEMAN, P.: Granulocyte-platelet Rosettes. Int. Congr.
Hematol. Abstr. (Jerusalem), 1974.
100.[69]. SEEMAN, P. and BROWN, G.M. (Editors): Frontiers in Neurology and Neuroscience
Research 1974. First Int. Symp. Neurosci. Inst., Univ. of Toronto. Univ. of Toronto Press,
August, 1974, 154 pages.
101.[70]. SEEMAN, P. and LEE, T.: Antipsychotic drugs: Direct correlation between clinical potency
and presynaptic action on dopamine neurones. Science 188: 1217-1219 (1975).
102.[71]. SEEMAN, P.: Answers of an M.D. to questions of an M.P. Can. Med. Assoc. J. 111: 707-
730 (1974).
103.[72]. MULLER, P. and SEEMAN, P.: Neuroleptics: Relation between cataleptic and anti-turning
actions, and role of the cholinergic system. J. Pharm. Pharmacol. 26: 981-984 (1974).
104.[73]. SEEMAN, P. and LEE, T.: Neuroleptic drugs: Direct correlation between clinical potency
and presynaptic action on dopamine neurons. In: Antipsychotic drugs, pharmacodynamics
and pharmacokinetics, edited by G. Sedvall, Karolinska Institute, Pergamon Press Ltd.,
Oxford, pp. 183-191 (1976).
105. SEEMAN, P.: Current advances in neuroscience and neurology research. Univ. of Toronto
Med. J. 52: 47-48 (1975).
106.[74]. STAIMAN, A.L. and SEEMAN, P.: Different sites of membrane action for tetrodotoxin and
lipid-soluble anesthetics. Can. J. Physiol. Pharmacol. 53: 513-524 (1975).
107. DONATI, F., KUNOV, H. and SEEMAN, P.: Post-tetanic hyperpolarization in squid giant
axons. Can. Fed. Biol. Soc. Abstr. 18: 104 (Abstr. 413) (1975).
108.[75]. SEEMAN, P.: Action and interaction of psychoactive drugs on nerve impulse conduction
and release of neurotransmitters. In: Clinical pharmacology of psychoactive drugs, edited by
E.M. Sellers, Alcoholism and Drug Addiction Research Foundation, Toronto, pp. 165-170
(1975).
109.[76]. SEEMAN, P. and SELLERS, E.M.: Editors, Principles Of Medical Pharmacology. 1st
Edition,1975, 448 pages, University of Toronto Press.
110. SEEMAN, P., WONG, M. and TEDESCO, J. : Tranquilizer receptors in rat striatum. Soc.
Neurosci. Abstr. 1: 405 (1975).
111. MULLER, P. and SEEMAN, P.: Alterations in dopaminergic sensitivity in chronically
pretreated rats. Soc. Neurosci. Abstr. 1: 412 (1975).
112. SEEMAN, P. and LEE, T.: Antipsychotic drugs: Direct correlation between clinical potency
and presynaptic actions on dopamine neurones. 6th Int. Congr. Pharmacol. Abstr. (1975).
113. SEEMAN, P.: cH or pH. Can. Med. Assoc. J. 112: 1384 (1975).
114.[77]. SEEMAN, P.: The actions of nervous system drugs on cell membranes. In: Cell membranes,
biochemistry, cell biology and pathology, edited by G. Weissmann and R. Claiborne, HP
Publ. Co., New York, N.Y. pp. 239-248 (1975).
115.[78]. SEEMAN, P., CHAU-WONG, M., TEDESCO, J. and WONG, K.: Brain receptors for
antipsychotic drugs and dopamine: Direct binding assays. Proc. Nat. Acad. Sci., U.S.A. 72:
4376-4380 (1975).
116. SEEMAN, P., LEE, T., CHAU-WONG, M. and WONG, K.: Correlation of antipsychotic
drug potency and neuroleptic receptor block. Soc. Neurosci. Abstr. 2: 878 (1976).
117. MULLER, P. and SEEMAN, P.: Increased specific neuroleptic binding after chronic
haloperidol in rats. Soc. Neurosci. Abstr. 2: 874 (1976).
118.[79]. SEEMAN, P., LEE, T., CHAU-WONG, M. and WONG, K.: Antipsychotic drug doses and
neuroleptic/dopamine receptors. Nature 261: 717-719 (1976).
119.[80]. BROWN, G.M., SEEMAN, P. and LEE, T.: Dopamine/neuroleptic receptors in basal
hypothalamus and pituitary. Endocrinology 99: 1407-1410 (1976).
120.[81]. SEEMAN, P. and SELLERS, E.M.: Editors, Principles Of Medical Pharmacology. Second
Edition, 489 pages, University of Toronto Press, 1976.
121.[82]. EZRIN-WATERS, C., MULLER, P. and SEEMAN, P.: Catalepsy induced by morphine or
haloperidol: Effects of apomorphine and anticholinergic drugs. Can. J. Physiol. Pharmacol.
54: 516-519 (1976).
122.[83]. STAIMAN, A. and SEEMAN, P.: Conduction-blocking concentrations of anesthetics
increase with nerve axon diameter: Studies with alcohol, lidocaine and tetrodotoxin on single
myelinated fibers. J. Pharmacol. Exp. Ther. 201: 340-349 (1977).
123.[84]. SEEMAN, P., LEE, T., CHAU-WONG, M., TEDESCO, J. and WONG, K.: Dopamine
receptors in human and calf brains, using 3H-apomorphine and an antipsychotic drug. Proc.
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125.[86]. SEEMAN, P.: Anti-schizophrenic drugs: Membrane receptor sites of action. Biochem.
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126.[87]. CURRAN, M. and SEEMAN, P.: Alcohol tolerance in a cholinergic nerve terminal. Relation
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127.[88]. SEEMAN, P.: Anesthetics and pressure reversal of anesthesia: Expansion and recompression
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128.[89]. WHITAKER, P.M. and SEEMAN, P.: Hallucinogen binding to dopamine/neuroleptic
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129.[90]. FRIEND, W.C., BROWN, G.M., JAWAHIR, G., LEE, T. and SEEMAN, P.: Effect of
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130.[91]. SEEMAN, P.: Brain chemistry, schizophrenia and major tranquilizers. Health Research
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132. LEE, T. and SEEMAN, P.: Dopamine receptors in human and calf brains. Soc. Biol.
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133. TEDESCO, J.L., BOWLES, J., McDERMED, J.D. and SEEMAN, P.: Conformational
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134. TITTLER, M., WEINREICH, P. and SEEMAN, P.: Brain dopamine receptor binding of 3H-
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135. EZRIN-WATERS, C. and SEEMAN, P.: Effect of chronic L-DOPA on apomorphine-
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136. WHITAKER, P.M. and SEEMAN, P.: Overlap of dopamine- and serotonin-displaceable
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137. LEE, T. and SEEMAN, P.: Dopamine receptors in normal and schizophrenic human brains.
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138. MULLER, P., BOWLES, J. and SEEMAN, P.: Dopaminergic and cholinergic receptors in
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139. BROWN, G.M., PORIETIS, A., SEEMAN, P., FRIEND, W.C. and LEE, T.: Dopamine
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140.[93]. SEEMAN, P., TITTLER, M., TEDESCO, J. and LEE, T.: Neuroleptic sites of membrane
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141.[94]. EZRIN-WATERS, C. and SEEMAN, P.: Haloperidol-induced tolerance to morphine
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142.[95]. SEEMAN, P., TITELER, M., TEDESCO, J., WEINREICH, P. and SINCLAIR, D.: Brain
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146.[99]. LEE, T., SEEMAN, P., TOURTELLOTTE, W.W., FARLEY, I.J. and HORNYKIEWICZ,
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147.[100]. LEE, T., SEEMAN, P., RAJPUT, A., FARLEY, I.J. and HORNYKIEWICZ, O.: Receptor
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148.[101]. NAGY, J.I., LEE, T., SEEMAN, P. and FIBIGER, H.C.: Direct evidence for presynaptic and
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149.[102]. EZRIN-WATERS, C. and SEEMAN, P.: L-DOPA reversal of hyperdopaminergic
behaviour. Life Sci. 22: 1027-1032 (1978).
150.[103]. TITELER, M., WEINREICH, P., SINCLAIR, D. and SEEMAN, P.: Multiple receptors for
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153.[106]. MULLER, P. and SEEMAN, P.: Dopaminergic supersensitivity after neuroleptics: Time-
course and specificity. Psychopharmacology 60: 1-11 (1978).
154. SEEMAN, P.: On "Essays in neurochemistry and Neuropharmacology", Vol. 1, edited by
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155. LEE, T., SEEMAN, P., RAJPUT, A., FARLEY, I. and HORNYKIEWICZ, O.: Parkinson's
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156.[107]. MULLER, P., BRITTON, R.S. and SEEMAN, P.: The effects of long-term ethanol on brain
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157.[108]. TITELER, M. and SEEMAN, P.: Selective labeling of alpha-adrenergic receptors in caudate
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160.[111]. HARTLEY, E.J. and SEEMAN, P.: The effect of varying 3H-spiperone concentration on its
binding parameters. Life Sci. 23: 513-518 (1978).
161. SEEMAN, P., LEE, T., HORNYKIEWICZ, O., FARLEY, I., BIRD, E., TOURTELLOTTE,
W.W. and SPOKES, E.M.: Schizophrenia: Increased neuroleptic binding in dopamine-rich
regions of human brains. 11th Colleg. Int. Neuropsychopharmacol. Abstr. (1978) p. 215.
162.[112]. CURRAN, M. and SEEMAN, P.: Mechanisms of ethanol tolerance at a cholinergic nerve
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163.[113]. DIRENFELD, L., SPERO, L., MAROTTA, J. and SEEMAN, P.: The L-DOPA on-off effect
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164.[114]. TITELER, M. and SEEMAN, P.: Antiparkinsonian drug doses and neuroleptic receptors.
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166.[115]. MULLER, P. and SEEMAN, P.: Presynaptic subsensitivity as a possible basis of
dopaminergic sensitization by long-term dopamine-mimetics. Eur. J. Pharmacol. 55: 149-157
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167.[116]. TEDESCO, J.L., SEEMAN, P. and McDERMED, J.D.: The conformation of dopamine at its
receptor: Binding of monohydroxy-2-aminotetralin enantiomers and positional isomers. Mol.
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168. WHITAKER, P.M. and SEEMAN, P.: Selective labelling of serotonin receptors by 3H-LSD.
Soc. Neurosci. Abstr. 4: 526 (1978).
169. TITELER, M. and SEEMAN, P.: Pre- and post-synaptic catecholamine receptors in calf
caudate. Soc. Neurosci. Abstr. 4: 523 (1978).
170. SEEMAN, P. and TEDESCO, J.: Presynaptic dopamine receptors labelled by 3H-
apomorphine. Soc. Neurosci. Abstr. 4: 521 (1978).
170A. TEDESCO, J.L. and SEEMAN, P.: Pre-synaptic dopamine receptor binding: Involvement of
the nitrogen lone electron pair. Soc. Neurosci. Abstr. 4: 522 (1978).
171. LEE, T. and SEEMAN, P.: Enhanced 3H-neuroleptic binding in post-mortem schizophrenic
brains. Soc. Neurosci. Abstr. 4: 496 (1978).
172. WEINREICH, P., LEE, T. and SEEMAN, P.: Striatal interdependence and pre- and post-
synaptic dopamine receptors. Soc. Neurosci. Abstr. 4: 524 (1978).
173.[117]. TITELER, M., SEEMAN, P. and HENN, F.: Differential centrifugation of 3H-apomorphine
and 3H-spiro-peridol binding sites. Eur. J. Pharmacol. 51: 459-460 (1978).
174.[118]. SEEMAN, P., WOODRUFF, G.N. and POAT, J.: Similar binding of 3H-ADTN and 3H-
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digitonin. Eur. J. Phamacol. 52: 151-152 (1978).
176.[120]. EZRIN-WATERS, C., SEEMAN, M.V. and SEEMAN, P.: Tardive dyskinesia in
schizophrenic outpatients: Prevalence and significant variables. J. Clin. Psychiat. 42: 16-22
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177.[121]. SEEMAN, P., WESTMAN, K., PROTIVA, M., JILEK, J., JAIN, P.C., SAXENA, A.K.,
ANAND, N., HUMBER, L. and PHILIPP, A.: Neuroleptic receptors: Stereoselectivity for
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178.[122]. LIST, S. and SEEMAN, P.: Dopamine agonists reverse the elevated 3H-neuroleptic binding
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179.[123]. WHITAKER, P.M. and SEEMAN, P.: High affinity 3H-serotonin binding to caudate:
Inhibition by hallucinogens and serotonergic drugs. Psychopharmacology 59: 1-5 (1978).
180. SEEMAN, P., LEE, T., HORNYKIEWICZ, O., FARLEY, I., BIRD, E., TOURTELLOTTE,
W.W., and SPOKES, E.M.: Schizophrenia: Increased neuroleptic binding in dopamine-rich
regions of human brain. 11th Colleg. Int.. Neuropsychopharmacologicum Abstr. [Vienna] p.
215, (1978).
181.[124]. HARTLEY, E.J., SPUHLER, K., PRASAD, K.N. and SEEMAN, P.: A neuroblastoma clone
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182.[125]. WHITAKER, P.M. and SEEMAN, P.: Selective labeling of apomorphine receptors by 3H-
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183. SEEMAN, P., LEE, T., BIRD, E.D., SPOKES, E.M., TOURTELLOTTE, W.W., FARLEY,
I. and HORNYKIEWICZ, O.: Neuroleptic receptors in post-mortem schizophrenic brains.
11th Colleg. Internat. Neuropsychopharmacologicum Abstr. (Vienna): p. 307 (1978).
184.[126]. TITELER, M. and SEEMAN, P.: Ergot and catecholamine potencies at catecholamine
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185.[127]. SEEMAN, P., LEE, T., BIRD, E.D. and TOURTELLOTTE, W.W.: Elevation of brain
neuroleptic/dopamine receptors in schizophrenia. In: Perspectives in schizophrenia research,
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188.[130]. DIRENFELD, L., SPERO, L., MAROTTA, J. and SEEMAN, P.: Chronic agonist-induced
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189.[131]. WEINREICH, P. and SEEMAN, P.: Effect of kainic acid on striatal dopamine receptors.
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190.[132]. SEEMAN, P., WESTMAN, K., COSCINA, D. and WARSH, J.J.: Serotonin receptors in
hippocampus and frontal cortex. Eur. J. Pharmacol. 66: 179-191 (1980).
191. TANG, S.W. and SEEMAN, P.: Effect of antidepressants on noradrenergic and serotonergic
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192.[133]. TITELER, M. and SEEMAN, P.: In vitro measurement of brain receptors for dopamine and
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193. EZRIN-WATERS, C., SEEMAN, M.V. and SEEMAN, P.: Prevalence of tardive dyskinesia
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195.[135]. TITELER, M. and SEEMAN, P.: Selective labeling of different dopamine receptors by a
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196.[136]. TITELER, M. and SEEMAN, P.: Radioreceptor labeling of pre- and post-synaptic dopamine
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165 (1980).
197. TANG, S.W. and SEEMAN, P.: The noradrenergic and serotonergic properties of
antidepressants. Can. Psychiat. Assn. Abstr. (Vancouver, Sept. 1979).
198. LIST, S., TITELER, M. and SEEMAN, P.: Properties of high affinity 3H-dopamine binding
sites in rat striatum. Soc. Neurosci. Abstr. 5: 654 (1979).
199. WEINREICH, P., TITELER, M. and SEEMAN, P.: Identification of 3H-clonidine binding
sites in rat brain. Soc. Neurosci. Abstr. 5: 576 (1979).
200. TITELER, M. and SEEMAN, P.: Agonist potencies at the dopamine receptor. Soc.
Neurosci. Abstr. 5: 664 (1979).
201. LEE, T. and SEEMAN, P.: Correlation of antipsychotic drug potency and neuroleptic
receptor inhibition of post-mortem human brains. Soc. Neurosci. Abstr. 5: 653 (1979).
202.[137]. LEE, T. and SEEMAN, P.: Abnormal neuroleptic/dopamine receptors in schizophrenia. Adv.
Biochem. Psychopharmacol. 21: 435-442 (1980).
203.[138]. SEEMAN, P., SELLERS, E.M. and ROSCHLAU, W.H.E.: Editors, Principles of Medical
Pharmacology. Third Edition, 690 pages, 1980.
204.[139]. TITELER, M., LIST, S. and SEEMAN, P.: High-affinity dopamine receptors (D3) in rat
brain. Communic. Psychopharmacol. 3: 411-420 (1979).
205.[140]. TANG, S.W. and SEEMAN, P.: Effect of antidepressant drugs on serotonergic and
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207.[142]. WEINREICH, P., DECK, J. and SEEMAN, P.: Multiple binding sites in human brain for 3H-
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208.[143]. TITELER, M. and SEEMAN, P.: Presynaptically acting catecholamines bind to alpha2-
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210. SEEMAN, P. and LEE, T.: Brain dopamine receptors (D2 and D3 sites) in Parkinson's disease
and schizophrenia. 12th Colleg. Int. Neuropsychopharmacologicum Abstr. (Goteborg), Progr.
Neuropsychopharma-col. 4, Suppl., 1980, Abstr. 609, p. 317.
211. SEEMAN, P.: Receptor research in psychopharmacology: Past and future. 12th Int. Colleg.
Neuropsycho-pharmacologicum Abstr. (Goteborg); Progr. Neuropsychopharmacol. 4, Suppl.,
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212. LEE, T. and SEEMAN, P.: Dopamine receptor binding in schizophrenia and Parkinson's
disease. 12th Int. Colleg. Neuropsychopharmacologicum Abstr. (Goteborg); Progr.
Neuropsychopharmacol. 4, Suppl., 1980, Abstr. 391, p. 221.
213. SEEMAN, P.: Brain dopamine receptors in schizophrenia. 12th Int. Colleg.
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214.[145]. MADRAS, B., DAVIS, A., KUNASHKO, P. and SEEMAN, P.: Solubilization of dopamine
receptors from human and dog brain. In: Psychopharmacology and biochemistry of neurotransmitter receptors, edited by H. Yamamura, R. Olsen and E. Usdin,Elsevier North
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215.[146]. LIST, S. and SEEMAN, P.: Dopamine receptors in human brain: comparison with rat and
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216.[147]. HELMESTE, D.M., SEEMAN, P.and COSCINA, D.V.: Relation between brain
catecholamine receptors and dopaminergic stereotypy in rat strains. Eur. J. Pharmacol. 69:
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217. TANG, S.W., SEEMAN, P. and KWAN, S.: Effect of chronic tricyclic antidepressant
treatment on serotonergic and histaminergic receptors. Soc. Neurosci. Abstr. 6: 861 (1980).
218. LIST, S. and SEEMAN, P.: High-affinity 3H-dopamine receptors in human brain. Soc.
Neurosci. Abstr. 6: 240 (1980).
219. MADRAS, B.K., DAVIS, A. and SEEMAN, P.: Solubilization of the neuroleptic/dopamine
(D2) receptor from dog striatum. Soc. Neurosci. Abstr. 6: 240 (1980).
220. HELMESTE, D.M., SEEMAN, P. and COSCINA, D,V.: Genetic differences in
catecholamine receptors and dopamine-mediated behaviour in rats. Soc. Neurosci. Abstr. 6: 3
(1980).
221. DAVIS, A., MADRAS, B.K. and SEEMAN, P.: Solubilization of the neuroleptic binding site
of human brain. Soc. Neurosci. Abstr. 6: 500 (1980).
222. LEE, T. and SEEMAN, P.: Dopamine receptors in schizophrenic human brains: differential
changes. Soc. Neurosci. Abstr. 6: 600 (1980).
223.[148]. SEEMAN, P.: Current biochemical research (on schizophrenia). Montage (Clarke Institute)
5(2): 1-4 (1979).
224.[149]. SEEMAN, P.: Dopamine and schizophrenia. Can. Psychiat. Assoc. Bull. Sept. 9-1 (1979).
225.[150]. DUMBRILLE-ROSS, A., TANG, S.W. and SEEMAN, P.: High-affinity binding of 3H-
mianserin to rat cerebral cortex. Eur. J. Pharmacol. 68: 395-396 (1980).
226.[151]. LEE, T., SEEMAN, P., HORNYKIEWICZ, O., BILBAO, J., DECK, J. and
TOURTELLOTTE, W.: Parkinson's disease: Low density and presynaptic location of D3
dopamine receptor sites. Brain Res. 212: 494-498 (1981).
227.[152]. DAVIS, A., MADRAS, B. and SEEMAN, P.: Solubilization of neuroleptic/dopamine
receptors of human brain striatum. Eur. J. Pharmacol. 70: 321-329 (1981).
228.[153]. LIST, S.J. and SEEMAN, P.: Resolution of the dopamine and serotonin receptor components
of 3H-spiperone binding to rat brain regions. Proc. Nat. Acad. Sci., U.S.A. 78: 2620-2624
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229.[154]. WEINREICH, P., CHIU, A., WARSH, J. and SEEMAN, P.: Multiple binding sites for 3H-
clonidine and 3H-WB-4101 in rat brain. Canad. J. Physiol. Pharmacol. 59: 1170-1177 (1981).
230.[155]. TANG, S.W., SEEMAN, P. and KWAN, S.: Differential effect of chronic desipramine and
amitriptyline treatment on rat brain adrenergic and serotonergic receptors. Psychiat. Res. 4:
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231.[156]. DAVIS, A., MADRAS, B.K. and SEEMAN, P.: Solubilized receptors for 3H-dopamine (D3
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232.[157]. WEINREICH, P. and SEEMAN, P.: Binding of adrenergic ligands ([3H]clonidine and
[3H]WB-4101) to multiple sites in human brain. Biochem. Pharmacol. 30: 3115-3120 (1981).
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dopamine receptors detected in the anterior pituitary. Eur. J. Pharmacol. 71: 143-146 (1981).
234.[159]. LEE, T. and SEEMAN, P.: Brain dopamine receptors in schizophrenia. In: Biological
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235.[160]. SEEMAN, P., TITELER, M. and LIST, S.: Dopamine receptors in brain and pituitary. In:
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236.[161]. CHAN, B., MADRAS, B.K., DAVIS, A. and SEEMAN, P.: Assay for soluble dopamine
receptors by the precipitation method. Eur. J. Pharmacol. 74: 53-59 (1981).
237. WATANABE, S. and SEEMAN, P.: Dopamine receptors in lesion-produced hyperactive rats.
8th Int. Congr. Pharmacol. Abstr. (Tokyo, 1981), p. 829 (Abstr. 0-37).
238.[161]. SEEMAN, P., and LIST, S.: Dopamine receptors and dopaminergic supersensitivity. In:
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Hagihara and S. Ebashi, Pergamon Press, New York, pp. 41-49, 1982.
239.[163]. SEEMAN, P. and LEE, T.: Dopamine receptors in the schizophrenic brain. In: Psychobiology
of Schizophrenia (C.u.O. Vogt and M. Hayashi symposium, Gifu, Japan, 1981), edited by M.
Namba and H. Kaiya, Pergamon Press, pp. 241-247, 1982.
240.[164]. SEEMAN, P. and LIST, S.: Multiple receptors for dopamine (D2, D3, D4). In: Advances in
Dopamine Research. Advances in the Biosciences 37, M. Kohsaka, edited by G.N. Woodruff,
T. Shohmori and Y. Tsukada, Pergamon Press, New York, pp. 61-70, 1982.
241. DAVIS, A., MADRAS, B.K., LILLY, L. and SEEMAN, P.: Solubilized 3H-dopamine
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243.[165]. SEEMAN, P.: Dopamine receptors in post-mortem schizophrenic brains. Lancet i: 1103
(1981).
244.[166]. MADRAS, B.K., DAVIS, A. and SEEMAN, P.: Comparison of soluble dopamine D2-
receptors from three species. Eur. J. Pharmacol. 78: 431-438 (1982).
245. HARTLEY, E.J. and SEEMAN, P.: Alpha-adrenoceptor development and hyperlocomotion
in young rats. Soc. Neurosci. Abstr. 7: 125 (1981).
246. HELMESTE, D.M. and SEEMAN, P.: Dopamine receptors, amphetamine response, and
hyperkinetic syndrome. Soc. Neurosci. Abstr. 7: 12 (1981).
247. LIST, S. and SEEMAN, P.: D3 and D4 dopaminergic binding sites detected by 3H-ADTN.
Soc. Neurosci. Abstr. 7: 10 (1981).
248. CHAN, B., SEEMAN, P., DUMBRILLE-ROSS, A. and MADRAS, B.K.: Solubilization and
partial purification of 3H-mianserin binding sites. Soc. Neurosci. Abstr. 7: 7 (1981).
249. MADRAS, B.K., DAVIS, A., LILLY, L., FRASER, C., VENTER, C. and SEEMAN, P.:
Partially purified dopamine/neuroleptic receptors (D2-type). Soc. Neurosci. Abstr. 7: 10
(1981).
250. DAVIS, A., FRASER, C.M., LILLY, L., MADRAS, B.K., VENTER, J.C. and SEEMAN, P.:
Monoclonal antibodies to partially purified D2 dopamine receptors. Soc. Neurosci. Abstr. 7:
10 (1981).
251. LEE, T and SEEMAN, P.: Pre- and post-synaptic dopamine receptors in schizophrenia.
Progr. Neuropsychopharmacol. 5(3): 283 (1981).
252.[167]. MADRAS, B.K., DAVIS, A., CHAN, B. and SEEMAN, P.: Solubilized
dopamine/neuroleptic receptors (D2-type). Progr. Neuropsychopharmacol. 5(3): 543-548
(1981).
253. DAVIS, A., LILLY, L., FRASER, C., VENTER, J.C., MADRAS, B.K. and SEEMAN, P.:
Characterization of partially purified neuroleptic/dopamine (D2-type) receptors and
subsequent antibody production. Progr. Neuropsychopharmacol. 5(3): 283 (1981).
254. LEE, T., LEE, S.L. and SEEMAN, P.: Dopamine receptor regulation in the rat. Progr.
Neuropsychopharma-col. 5(3): 283 (1981).
255. HELMESTE, D.M. and SEEMAN, P.: Genetic differences in CNS dopamine receptors and
possible relations to amphetamine-induced locomotion in mice. Progr.
Neuropsychopharmacol. 5(3): 283 (1981).
256. LILLY, L., DAVIS, A., MADRAS, B.K., FRASER, C.M., VENTER, J.C. and SEEMAN, P.:
Brain D2 dopamine receptors: partial purification. Soc. Neurosci. Abstr. 7: 10 (1981).
257.[168]. HARTLEY, E.J. and SEEMAN, P.: Development of receptors for dopamine and
noradrenaline in rat brain. Europ. J. Pharmacol. 91: 391-398 (1983).
258. DAVIS, A., FRASER, C.M., LILLY, L., MADRAS, B.K., SEEMAN, P. and VENTER, J.C.:
Partial purification of brain D2 dopamine receptors and the development of monoclonal
antibodies. Neurosci. Lett. 7: S191 (1981).
259. SEEMAN, P. and LEE, T.: Brain dopamine receptors in schizophrenia. 134th Amer.
Psychiat. Assoc. Abstr. p. 38 (1981), Abstr. 16B.
260.[169]. CHAN, B., SEEMAN, P., DAVIS, A. and MADRAS, B.K.: Ascorbate injury and EDTA (or
manganese) protection of dopamine receptors. Eur. J. Pharmacol. 81: 111-116 (1982).
261.[170]. HELMESTE, D.M. and SEEMAN, P.: Amphetamine-induced hypolocomotion in mice with
more brain D2 dopamine receptors. Psychiat. Res. 7: 351-360 (1982).
262.[171]. HELMESTE, D.M. and SEEMAN, P.: 3H-Haloperidol binds to more than one site in rat brain
striatum. Biochem. Pharmacol. 32: 741-744 (1983).
263.[172]. TITELER, M. and SEEMAN, P.: Effects of anti-hypertensive clonidine congeners on alpha-
adrenergic receptors. Canad. J. Physiol. Pharmacol. 60: 342-344 (1982)
264.[173]. LIST, S.J., WREGGETT, K.A. and SEEMAN, P.: Striatal binding of 3H-ADTN to two
dopaminergic sites distinguished by their low and high affinity for neuroleptics. J. Neurosci.
2: 895-906 (1982).
265.[174]. LILLY, L., DAVIS, A., FRASER, C.M., SEEMAN, P. and VENTER, J.C.: Characterization
of brain D2 dopamine receptors. Neurochem. Internat. 7: 363-368 (1985).
266.[175]. LIST, S. and SEEMAN, P.: 3H-Dopamine labelling of D3 dopaminergic sites in human, rat
and calf brain. J. Neurochem. 39: 1363-1373 (1982).
267.[176]. SEEMAN, P.: Nomenclature of central and peripheral dopaminergic sites and receptors.
Biochem. Pharmacol. 31: 2563-2568 (1982).
268.[177]. SEEMAN, P. and SEEMAN, M.V.: Schizophrenia and dopamine receptors. Psychiat. Newsl.
Univ. Toronto 1: p.l (1981).
269.[178]. SEEMAN, P., ULPIAN, C., WREGGETT, K.A. and WELLS, J.: Dopamine receptor
parameters detected by 3H-spiperone depend on tissue concentration: analysis and examples.
J. Neurochem. 43: 221-235 (1984).
270.[179]. SEEMAN, P.: Dopamine receptor measurement with 3H-ligands. In: Methods in Biogenic
Amine Research, edited by S. Parvez, T. Nagatsu and H. Parvez, Elsevier Science, B.V.,
Amsterdam, 1983, pp. 591-622.
271.[180]. SEEMAN, P.: Schizophrenia and dopamine receptors. In: A method of psychiatry, edited by
S.E. Greben, V.M. Rakoff, G. Voineskos, Lea & Febiger, Philadelphia, 1985, pp. 70-77.
272.[181]. WREGGETT, K. and SEEMAN, P.: Classification and agonist requirements of dopamine
receptors. In: Dopamine Receptor Agonists, edited by A. Carlsson and J.L.G. Nilsson,
Swedish Pharmaceutical Press, Stockholm, 1983, pp. 30-40; Acta Pharmaceut. Suec. Suppl.
1: 30-40 (1983).
273.[182]. SEEMAN, P.: Dopamine receptors in brain. In: Brain receptor methodologies, Part A, edited
by P.J. Marangos, I.C. Campbell, and R.M. Cohen, Academic Press, 1984, pp. 285-307.
274. SEEMAN, P., ULPIAN, C. and WELLS, J.: Dopamine receptor parameters (detected by 3H-
spiperone) depend on tissue concentration. Soc. Neurosci. Abstr. 8: 718 (1982).
275. WREGGETT, K.A., GEORGE, S.R. and SEEMAN, P.: Modulation of the D2 dopamine
receptor in calf caudate by guanine nucleotide. Soc. Neurosci. Abstr. 8: 719 (1982).
276. GEORGE, S.R., WREGGETT, K.A. and SEEMAN, P.: Dopaminergic binding sites in the
anterior pituitary discriminated by agonists and guanine nucleotides. Soc. Neurosci. Abstr. 8:
720 (1982).
277. LILLY, L., MAGNAN, J., DAVIS, A. and SEEMAN, P.: Irreversible 3H-ligands for
dopamine receptor purification. Soc. Neurosci. Abstr. 8: 719 (1982).
278.[183]. OTTON, S.V., KALOW, W. and SEEMAN, P.: High affinity of quinidine for a
stereoselective microsomal binding site as determined by a radioreceptor assay. Experientia
40: 973-974 (1984).
279.[184]. GEORGE, S., BINKLEY, K. and SEEMAN, P.: Dopamine receptor sites and states in human
brain. J. Neural Transm. Suppl. 18: 149-156 (1983).
280.[185]. GEORGE, S., WATANABE, M. and SEEMAN, P.: Commentary: The dopamine receptor of
the anterior pituitary gland. In: Dopamine Receptors, edited by C. Kaiser and J. Kebabian,
Amer. Chem. Soc. Symp. 224, Amer. Chem. Soc., Washington, pp. 93-99, 1983.
281. HATTORI, T., WEINREICH, P. and SEEMAN, P.: Implications of trans-synaptic
degeneration for receptor binding studies in the rat striatum. Soc. Neurosci. Abstr. 8: 646
(1982).
282.[186]. WREGGETT, K.A. and SEEMAN, P.: Agonist high- and low-affinity states of the D2
dopamine receptor in calf brain: partial conversion by guanine nucleotide. Mol. Pharmacol.
25: 10-17 (1984).
283. SEEMAN, P.: This week's Citation Classic. Curr. Cont. Life Sci. 26(4): 22 (1983).
284.[187]. RAJPUT, A.H., ROZDILSKY, B., HORNYKIEWICZ, O., SHANNAK, K., LEE, T. and
SEEMAN, P.: Reversible drug-induced Parkinsonism. Clinicopathologic study of two cases.
Arch. Neurol. 39: 644-646 (1982).
285.[188]. LILLY, L., FRASER, C.M., JUNG, C., SEEMAN, P. and VENTER, J.C.: Molecular size of
the canine and human brain D2 dopamine receptor as determined by radiation inactivation.
Mol. Pharmacol. 24: 10-14 (1983).
286. SEEMAN, P., ULPIAN, C. and TOURTELLOTTE, W.W.: Elevation of D2 dopamine
receptors in schizophrenia brain. Int. Congr. Neurochem. Abstr. (Vancouver). J. Neurochem.
41 Suppl.: p. S33 (1983).
287. GEORGE, S., WATANABE, M. and SEEMAN, P.: Regulation of the states of the D2
dopamine receptor in the anterior pituitary. In: Current Frontiers in Catecholamine Research.
(5th Int. Catecholamine Symp. Abstr., Goteborg), edited by E. Usdin, A. Carlsson, A.
Dahlstrom and J. Engel, Pergamon, Oxford (1983); Prog. Neuropsychopharmacol. Biol.
Psychiatr. Suppl. (1983), abstr. 170, p. 145.
288.[189]. GRIGORIADIS, D. and SEEMAN, P.: Complete conversion of brain D2 dopamine receptors
from the high- to the low-affinity state for dopamine agonists, using sodium ions and guanine
nucleotide. J. Neurochem. 44: 1925-1935 (1985).
289.[190]. GEORGE, S.R., WATANABE, M. and SEEMAN, P.: Dopamine D2 receptors in the anterior
pituitary: A single population without reciprocal agonist/antagonist states. J. Neurochem. 44:
1168-1177 (1985).
290. GEORGE, S.R., WATANABE, M. and SEEMAN, P.: The dopamine receptor of the anterior
pituitary gland. Int. Congr. Neurochem. Abstr. (Vancouver). J. Neurochem. 41 Suppl.: p.
S110 (1983).
291.[191]. WATANABE, S. and SEEMAN, P.: Dopamine receptor density in rat striatum over 24
hours: Lack of detectable changes. Biol. Psychiat. 19: 1249-1253 (1984).
292.[192]. SEEMAN, P. and ULPIAN, C: Neuroleptics have identical potencies in human brain limbic
and putamen regions. Europ. J. Pharmacol. 94: 145-148 (1983).
293. SEEMAN, P., ULPIAN, C. and TOURTELLOTTE, W.W.: Elevation of D2 dopamine
receptors in schizophrenia brain. Soc. Neurosci. Abstr. 9: 31 (1983).
294.[193]. GUAN, J.-H., NEUMEYER, J.L., FILER, C.N., AHERN, D.G., LILLY, L., WATANABE,
M., GRIGORIADIS, D. and SEEMAN, P.: Aporphines. 58. N-(2-Chloroethyl)-[8,9-
2
H]norapomorphine, an irreversible ligand for dopamine receptors: synthesis and application.
J. Med. Chem. 27: 806-809 (1984).
295.[194]. VENTER, J.C., FRASER, C.M., LILLY, L., SEEMAN, P., EDDY, B. and SCHABER, J.:
The structure of neurotransmitter receptors (adrenergic, dopaminergic and muscarinic cholinergic). In: Catecholamine Research (5th Int. Catecholamine Symp., Goteborg), edited
by E. Usdin, A. Carlsson, A. Dahlstrom and J. Engel, Pergamon, Oxford, (1984); Progr.
Neuropsychopharmacol. Biol. Psychiatr. Suppl. (1983), (Abstr. 506: p. 307).
296. GEORGE, S.R., WATANABE, M. and SEEMAN, P.: The brain D2 dopamine receptor
differs from the pituitary D2 receptor, as detected by (-)3-PPP. Soc. Neurosci. Abstr. 9: 31
(1983).
297. GRIGORIADIS, D. and SEEMAN, P.: Sodium ions convert brain D2 dopamine receptors
from high to low affinity for dopamine agonists. Soc. Neurosci. Abstr. 9: 31 (1983).
298. LILLY, L.B. and SEEMAN, P.: D2 dopamine receptor purification using 3H-NCA:
Identification of a 40,000 dalton binding protein. Soc. Neurosci. Abstr. 9: 30 (1983).
299. WATANABE, M., GEORGE, S.R. and SEEMAN, P.: The proportion of D2 dopamine
receptors in high and low affinity states depends on the agonist, cations, guanine nucleotides,
and temperature. Soc. Neurosci. Abstr. 9: 994 (1983).
300.[195]. SEEMAN, P.: Brain dopamine receptors. Pharmacol. Rev. 32: 229-313 (1980).
301. MICHNICK, S., and SEEMAN, P.: Incorporation of functional dopamine receptors into
planar lipid bilayer membranes. Soc. Neurosci. Abstr. 9: 1144 (1983).
302.[196]. MADRAS, B.K. and SEEMAN, P.: Drug potencies on partially purified brain D2 dopamine
receptors. J. Neurochem. 44: 856-861 (1985).
304.[197]. GRIGORIADIS, D. and SEEMAN, P.: The dopamine/neuroleptic receptor. Canad. J. Neurol.
Sci. 11: 108-113 (1984).
305. GEORGE, S.R., WATANABE, M. and SEEMAN, P.: Guanine nucleotides and sodium ions
modulate the sensitivity of anterior pituitary dopamine receptors to dopamine agonists and
antagonists. 7th Int. Congr. Endocrinol. Abstr. (July, 1984), p. 573, Abstr. 626, Elsevier
Science B.V. (1984).
306.[198]. TANG, S.W., GLAISTER, J., DAVIDSON, L., TOTH, R., JEFFRIES, J.J. and SEEMAN,
P.: Total and free plasma neuroleptic levels in schizophrenic patients. Psychiatry Res. 13:
285-293 (1984).
307.[199]. SEEMAN, P., ULPIAN, C., BERGERON, C., RIEDERER, P., JELLINGER, K., GABRIEL,
E., REYNOLDS, G.P. and TOURTELLOTTE, W.W.: Bimodal distribution of dopamine
receptor densities in brains of schizophrenics. Science 225: 728-731 (1984).
308.[200]. SEEMAN, P.: Brain dopamine receptors in schizophrenia. In: New Perspectives in
Schizophrenia. M.N. Menuck and M.V. Seeman (Eds.), Macmillan Publ. Co., New York,
1985, pp. 71-79.
309.[201]. SEEMAN, P.: Dopamine receptors. In: Discussions in Neuroscience 2: 56-58 (1985), Brain
metabolism and imaging, edited by W. Feindel, R.S.J. Frackowiak, D. Gadian, P.L.
Magistretti and M.R. Zalutsky, Fondation pour 1'Etude du Systeme Nerveux Central et
Peripherique, Geneva.
310. SEEMAN, P.: Brain catecholamine receptors. 14th Northeastern Regional Mtng., Amer.
Chem. Soc. Abstr. (Fairfield, June 1984), p. 34, Abstr. 67 (1984).
311.[202]. SEEMAN, P.: Brain dopamine receptors in schizophrenia. In: Neuroreceptor Mechanisms in
Human Diseases, B.M. edited by Conti-Tronconi, M. Fanciullacci, F. Sicuteri and L.
Terenius, Menarini Foundation, Florence, March 1984.
312.[203]. GEORGE, S.R., WATANABE, M., DI PAOLO, T., FALARDEAU, P., LABRIE, F., &
SEEMAN, P.: The functional state of the dopamine receptor in the anterior pituitary is in the
high-affinity form. Endocrinology 117: 690-697 (1985).
313. SEEMAN, P., GEORGE, S.R., WATANABE, M. and GRIGORIADIS, D.: Pituitary and
presynaptic D2 dopamine receptors function in high-affinity state for dopamine. Postsynaptic
ones are in a low-affinity state. 9th Int. Congr. Pharmacol. Abstr. (London, July 1984), Abstr.
484.
314.[204]. HELMESTE, D.M. and SEEMAN, P.: Genetic differences in brain dopamine receptors and
amphetamine response: Possible model for hyperkinetic children. In: Developmental
Pharmacology, edited by S.M. MacLeod, A.B. Okey and S.P. Spielberg, Alan R. Liss, Inc.,
New York, pp. 401-403 (1983).
315.[205]. SEEMAN, P., GRIGORIADIS, D., GEORGE, S.R., WATANABE, M. and ULPIAN, C:
Functional states of dopamine receptors. In: Dopaminergic Systems and Their Regulation,
edited by G.N. Woodruff, J.A. Poat and P.J. Roberts, Macmillan Press, London (1986), pp.
97-109.
316.[206]. SEEMAN, P.: Brain dopamine receptors in schizophrenia and tardive dyskinesia. In:
Dyskinesia, Research and Treatment, edited by D. Casey, T. Chase, A.V. Christensen and J.
Gerlach, Psychopharmacology Supple-mentum series, Vol. 2, Springer-Verlag Berlin (1985),
pp. 2-8.
317. SEEMAN, P., GEORGE, S.R., and WATANABE, M.: Presynaptic dopamine receptors
operate in the high-affinity state for dopamine. Post-synaptic ones work in low-affinity state.
Soc. Neurosci. Abstr. 10: 278 (1984).
318.[207]. NIZNIK, H.B., GUAN, J.H., NEUMEYER, J.L., and SEEMAN, P.: A dopamine D2 receptor
photolabel: azidoclebopride. Europ. J. Pharmacol. 104: 389-390 (1984).
319.[208]. DUMBRILLE-ROSS, A., and SEEMAN, P.: Dopamine receptor elevation by
cholecystokinin. Peptides 5: 1207-1212 (1985).
320.[209]. SEEMAN, P.: Dopamine/neuroleptic receptors in schizophrenia. In: Handbook of Studies in
Schizophrenia, Part 2, edited by G.D. Burrows, T.R. Norman and G. Rubinstein, Elsevier
Science B.V. (Biomedica Div.), Am-sterdam, 1986, pp. 251-259.
321. DUMBRILLE-ROSS, A., & SEEMAN, P.: Dopamine receptor elevation by cholecystokinin.
Soc. Neurosci. Abstr. 10: 536 (1984).
322. GEORGE, S.R., WATANABE, M., and SEEMAN, P.: D2 dopamine receptor interactions
with agonists and antagonists are modulated by sodium ions. Soc. Neurosci. Abstr. 10: 278
(1984).
323. FALARDEAU, P., DI PAOLO, T., LABRIE, F., GEORGE S., WATANABE, M., and
SEEMAN, P.: The functional state of the dopamine receptor in the anterior pituitary is the
high-affinity form. Soc. Neurosci. Abstr. 10: 240 (1984).
324. GRIGORIADIS, D., GEORGE, S.R., WATANABE, M., and SEEMAN, P.: Dopamine D2
receptor density increases markedly, using constant infusion of haloperidol by osmotic pump.
Soc. Neurosci. Abstr. 10: 241 (1984).
325. NIZNIK, H.B., GRIGORIADIS, D., PRI-BAR, BUCHMAN, O., and SEEMAN, P.:
Dopamine D2 receptors labeled by a new high-affinity ligand: 3H-YM-09151. Soc. Neurosci.
Abstr. 10: 277 (1984).
326.[210]. WATANABE, M., GEORGE, S.R., and SEEMAN, P.: Dependence of dopamine receptor
conversion from agonist high- to low-affinity state on temperature and sodium ions. Biochem.
Pharmacol. 34:2459-2463 (1985).
327. WATANABE, M., GEORGE, S.R., and SEEMAN, P.: Dopamine receptor regulation in
brain and pituitary. 14th Mtng. Jap. Soc. Psychopharmacol. Abstr. (1984).
328.[211]. NIZNIK, H.B., GUAN, J.H., NEUMEYER, J.L., and SEEMAN, P.: A photoaffinity ligand
for dopamine D2 receptors: azidoclebopride. Mol. Pharmacol. 27: 193-199 (1985).
329.[212]. SEEMAN, P., ULPIAN, C., GRIGORIADIS, D., PRI-BAR, I., and BUCHMAN, O.:
Conversion of dopamine D1 receptors from high to low affinity for dopamine. Biochem.
Pharmacol. 34: 151-154 (1985).
330.[213]. NIZNIK, H.B., GRIGORIADIS, D.E., PRI-BAR, I., BUCHMAN, O., and SEEMAN, P.:
Dopamine D2 receptors are selectively labeled by a benzamide neuroleptic: 3H-YM-09151-2.
Naunyn-Schmiedeberg's Arch. Pharmacol. 329: 333-343 (1985).
331.[214]. NIZNIK, H.B., DUMBRILLE-ROSS, A., GUAN, J.H., NEUMEYER, J.L., and SEEMAN,
P.: Dopamine D2 receptors photolabeled by iodo-azido-clebopride. Neurosci. Lett. 55: 267-
272 (1985).
332.[215]. GEORGE, S.R., WATANABE, M., and SEEMAN, P.: Dopamine D2 receptors in brain and
anterior pituitary recognize agonist and antagonist actions of (-)-3-PPP. J. Neural Transm. 64:
13-33 (1985).
333. RAMSBY, S.R., WATANABE, M., and SEEMAN, P.: 2-Amino- and 2-halo-aporphines as
ligands for the dopamine receptor. Int. Med. Chem. Mtng. Abstr., Uppsala (1984).
334.[216]. SEEMAN, M.V., and SEEMAN, P.: Molecular Psychiatry, Receptor density and Receptor
sensitivity states. Integrative Psychiatry 4: 41-43 (1986).
335.[217]. NEUMEYER, J.L., GUAN, J.-H., NIZNIK, H.B. DUMBRILLE-ROSS, A., SEEMAN, P.,
PADMAN-ABHAN, S., and ELMALEH, D.: Novel photoaffinity label for the dopamine D2
receptor: synthesis of 4-azido-5-iodo-2-methoxy-N-[1-(phenylmethyl)-4-
piperidinyl]benzamide (Iodoazidoclebopride, IAC) and the corresponding 125I-labelled
analogue. J. Med. Chem. 28: 405-407 (1985).
336.[218]. SEEMAN, P. and GRIGORIADIS, D.: Dopamine receptors in brain and periphery.
Neurochem. Int. 10: 1-25 (1987).
337.[219]. DUMBRILLE-ROSS, A., & SEEMAN, P.: Dopamine agonist high-affinity state in
solubilized D2 receptors in striatum, but not in anterior pituitary. Biochem. Pharmacol. 36:
2095-2099 (1987).
338. GUAN, J.-H., NEUMEYER, J.L., NIZNIK, H.B., DUMBRILLE-ROSS, A., SEEMAN, P.,
ELMALEH, D. and PADMANABHAN, S.: Novel photoaffinity label for the dopamine D2
receptor: Iodoazidoclebopride and the corresponding 125I-labeled analog. 189th Amer. Chem.
Soc. Med. Chem. Div. Abstr. (1985), Abstr. 92.
339.[220]. GUTTMAN, M., and SEEMAN, P.: Dopamine D2 receptor density in Parkinsonian brain is
constant for duration of disease, age and duration of L-DOPA therapy. Adv. Neurol. 45: 51-
57 (1986).
340. ELMALEH, D.R., PADMANABHAN, S., GUAN, J.-H., NEUMEYER, J.L., NIZNIK, H.B.,
and SEEMAN, P.: The in-vivo distribution of a novel photoaffinity label for the dopamine
D2 receptor. 12th Int. Symp. Cerebral blood flow and metabolism Abstr. (Lund) 1985.
342.[221]. WATANABE, M., GEORGE, S.R., and SEEMAN, P.: Regulation of anterior pituitary D2
dopamine receptors by magnesium and sodium ions. J. Neurochem. 45: 1842-1849 (1985).
343.[222]. SEEMAN, P., WATANABE, M., GRIGORIADIS, D., TEDESCO, J.L., GEORGE, S.R.,
SVENSSON, U., NILSSON, J.L.G., and NEUMEYER J.L.: Dopamine D2 receptor binding
sites for agonists: A tetrahedral model. Mol. Pharmacol. 28: 391-399 (1985).
344. GEORGE, S.R., and SEEMAN, P.: Regulation of the high and low agonist-affinity states of
dopamine receptors. Canad. Fed. Biol. Soc. Abstr. 28: p. 29 (Abstr. S-58) (1985).
345.[223]. DUMBRILLE-ROSS, A. NIZNIK, H., and SEEMAN, P.: Separation of dopamine D1 and D2
receptors. Europ. J. Pharmacol. 110: 151-152 (1985).
346.[224]. GUTTMAN, M., SEEMAN, P., BERGERON, C., RIEDERER, P., JELLINGER, K., and
TOURTEL-LOTTE, W.W.: Dopamine D2 receptor density remains constant in treated
Parkinson's disease. Annals Neurol. 19: 487-492 (1986).
347.[225]. SEEMAN, P., and GRIGORIADIS, D.: Dopamine D2 receptor dissociation constant for
spiperone: Identical values using 3H-labeled agonist or 3H-labeled antagonist. Biochem.
Pharmacol. 34: 4065-4066 (1985).
348.[226]. HORN, A.S., TEPPER, P., VAN DER WEIDE, J., WATANABE, M., GRIGORIADIS, D.,
and SEEMAN, P.: Synthesis and radioreceptor binding activity of N-0437, a new, extremely
potent and selective D2 dopamine receptor agonist. Pharmaceutisch Weekblad Sci. Ed. 7: 208-
211 (1985).
349.[227]. NIZNIK, H.B., OTSUKA, N.Y., DUMBRILLE-ROSS, A., GRIGORIADIS, D., TIRPAK, A.,
and SEEMAN, P.: Dopamine D1 receptors characterized with [3H]-SCH-23390.
Solubilization of a guanine nucleotide-sensitive form of the receptor. J. Biol. Chem. 261:
8397-8406 (1986).
350.[228]. GUTTMAN, M., and SEEMAN, P.: L-DOPA reverses the elevated D2 dopamine receptor
density in Parkinson's diseased striatum. J. Neural Transm. 64: 93-103 (1985).
351. RAMSBY, S., NEUMEYER, J., and SEEMAN, P.: 2-Fluoroapomorphine, a potent ligand for
the dopamine receptor. 189th Amer. Chem. Soc. Div. Med. Chem. Abstr. (1985), Abstr. 91.
352.[229]. GRIGORIADIS, D., and SEEMAN, P.: 3H-Domperidone labels only a single population of
receptors which convert from high to low affinity for dopamine in rat brain. Naunyn-
Schmiedeberg's Arch. Pharmacol. 332: 21-25 (1986).
353. BZOWEJ, N.H., and SEEMAN, P.: Age and dopamine D1 and D2 receptors in human brain.
Soc. Neurosci. Abstr. 11: 889 (1985).
354. DUMBRILLE-ROSS, A., NIZNIK, H.B., and SEEMAN, P.: Dopamine D1 amd D2 receptor
interactions. Soc. Neurosci. Abstr. 11: 716 (1985).
355.[230]. SEEMAN, P.: Dopamine receptors in human brain diseases. In: Structure and function of
dopamine receptors, edited by I. Creese and C.M. Fraser, vol 9 of Receptor Biochemistry and
Methodology, Alan R. Liss, New York, 1987, pp. 233-245.
356.[231]. KOHNO, A., SEEMAN, P., and CINADER, B.: Age-related changes of beta-adrenoceptors
in aging inbred mice. J. Gerontol. 41: 439-444 (1986).
357.[232]. SEEMAN, P.: Schizophrenia and dopamine receptors. In: New Perspectives in Treatment of
Schizophrenia, edited by D.A.W. Johnson, Symp. of World Psychiatr. Assoc. (1985), H.
Lundbeck A/S, Copenhagen, 1986, pp. 8-14.
358.[233]. ELMALEH, D.R., PADMANABHAN, S., NIZNIK, H.B., SEEMAN, P., GUAN, J.-H., and
NEUMEYER, J.L.: In vivo evaluation of 125I-labeled iodoclebopride and iodoazidoclebopride
binding to the dopamine D2 receptor. In: Alzheimer's and Parkinson's Disease, edited by A.
Fisher, I. Hanin and C. Lachman. Plenum publishing Corp., New York, 1986, pp. 645-653.
359.[234]. SEEMAN, P.: The absolute density of neurotransmitter receptors in brain: example for
dopamine receptors. J. Pharmacol. Methods 17: 347-360 (1987).
360.[235]. NIZNIK, H.B., GRIGORIADIS, D.E., OTSUKA, N.Y., DUMBRILLE-ROSS, A., and
SEEMAN, P.: The dopamine D1 receptor: Partial purification of a digitonin-solubilized
receptor-guanine nucleotide binding complex. Biochem. Pharmacol. 35: 2974-2977 (1986).
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467.[303]. SUGAMORI, K.S., SUNAHARA, R.K., GUAN, H.-C., BULLOCH, A.G.M., TENSEN, C.P.,
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472.[307]. SEEMAN, P., ULPIAN, C., LARSEN, R.D., and ANDERSON, P.S.: Dopamine receptors
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473. WONG, D.T., MOORE, N.A., CALLIGARO, D.O., BYMASTER, F., and SEEMAN, P.:
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479.[312]. SEEMAN, P., and VAN TOL, H.H.M.: Dopamine D4 receptors bind inactive (+)-aporphines,
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482. SEEMAN, P.: Schizophrenia, antipsychotic drugs and D4. Neuropsychopharmacology 9:
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483.[315]. SEEMAN, P., SUNAHARA, R.K., and NIZNIK, H.B.: Receptor-receptor link in membranes
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484.[316]. DASILVA, J.N., WILSON, A.A., SEEMAN, P., and HOULE, S.: Synthesis of [11C]SKF
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485.[317]. SEEMAN, P., and VAN TOL, H.H.M.: Dopamine receptor pharmacology. Trends in
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486.[318]. DEMCHYSHYN, L.L., SRIKANT, C.B., SUNAHARA, R.K., KENT, G., SEEMAN, P.,
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488.[320]. NOBREGA, J.N., and SEEMAN, P.: Dopamine D2 receptors mapped in rat brain with
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489.[321]. PHILLIPS, S.T., DE PAULIS, T., BARRON, B.M., SIEGEL, B.W., SEEMAN, P., VAN
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490. SEEMAN, P: Dopamine Receptors: Basic and Clinical. Jap. J. Pharmacol. 64 (Suppl. I): p.
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491.[322]. SEEMAN, P, ULPIAN, C., CHOUINARD, G., VAN TOL, H.H.M., DWOSH, H.,
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492. SUNAHARA, R.K., NIZNIK, H.B., and SEEMAN, P.: Dopamine D1-D2 receptor crosstalk
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493. SCHOOTS, O., YUE, K.-T., HAMPSON, D.R., MACDONALD, J.F., SEEMAN, P., and
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494.[323]. BYMASTER, F.P., CALLIGARO, D.O., FALCONE, J.F., MARSH, R.D., MOORE, N.A.,
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495. SEEMAN, P.,: Schizophrenia and dopamine receptors. J. Psychopharmacol.: p. A43, Abstr.
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497.[325]. BEISCHLAG, T.V., MARCHESE, A., MEADOR-WOODRUFF, J.H, DAMASK, S.P.,
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498.[326]. SEEMAN, P.: Therapeutic receptor-blocking concentrations of neuroleptics. Int. Clin.
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499.[327]. PHILLIPS, S.T., DE PAULIS, T., NEERGAARD, J.R., BARON, B.M., SIEGEL, B.W.,
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500.[328]. SEEMAN, P., and VAN TOL, H.H.M.: Dopamine D4-like receptor elevation in
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501. BEISCHLAG, T.V., MEADOR-WOODRUFF, J.H., MARCHESE, A., O’DOWD, B.F.,
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502.[329]. LIU, I.S.C., SEEMAN, P., SANYAL, S., ULPIAN, C., RODGERS-JOHNSON, P.E.B.,
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505.[332]. SEEMAN, P.: Dopamine receptors as new targets for novel drugs. Current Approaches to
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508. MARCHESE, A., NGUYEN, T., JUNG, B.P., SHEN, Y., SALDIVIA, V.R., SEEMAN, P.,
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510. VAN TOL, H.H.M., SEEMAN, P., LIU, I., SANYAL, S., ASGHARI, V., OLDENHOF, J.,
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511. SEEMAN, P., and VAN TOL, H.H.M.: Antipsychotics block D2 and D4. New site in
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512. SEEMAN, P., and VAN TOL, H.H.M.: Dopamine D4 receptors in schizophrenia? Reply. J.
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513. SEEMAN, P., and VAN TOL, H.H.M.: Therapeutic receptor-blocking concentrations of
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514. SEEMAN, P., and VAN TOL, H.H.M.: D4 receptors and schizophrenia. J. Neurochem. 65:
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515.[336]. SEEMAN, P., CORBETT, R., and VAN TOL, H.H.M.: Atypical neuroleptics have low
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516.[337]. SEEMAN, P., CORBETT, R., NAM, D., and VAN TOL, H.H.M.: Dopamine and serotonin
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517.[339]. SEEMAN, P., and KAPUR, S.: Clozapine occupies high levels of dopamine D2 receptors.
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518.[340]. SEEMAN, P.: Clozapine withdrawal: serotonergic or dopaminergic mechanisms? Arch Gen.
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519. BOV, C., KLIMKE, A., HOLSCHBACH, M., HERZOG, H., ROTA-KOPS, E.,
MÜHLENSIEPEN, H., SONNENBERG, F., WUNDERLICH, G., SEEMAN, P., VAN TOL,
H.H.M., MARKSTEIN, R., GAEBEL, W., STÖCKLIN, G., and MÜLLER-GÄRTNER,
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520.[341]. SEEMAN, P., CORBETT, R., and VAN TOL, H.H.M.: Dopamine D4 receptors may
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522.[343]. SEEMAN, P., TALLERICO, T., CORBETT, R., VAN TOL, H.H.M., and KAMBOJ, R.K.:
Commentary: Role of dopamine D2, D4, and serotonin 2A receptors in antipsychotic action
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523. SEEMAN, P.: Schizophrenia and dopamine receptors. 19th Mtng. Can. College
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524.[344]. NG, G., O’DOWD, B.F., LEE, S.P., CHUNG, H.T., BRANN, M.R., SEEMAN, P., and
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525. SEEMAN, P.: Olanzapine blocks type 2 and type 4 dopamine receptors. 4th Int. Conf. on
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526. LEE, S.P., G.Y.K. NG, ZAWARYNSKI, P., SEEMAN, P., O’DOWD, B.F., and GEORGE,
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527.[345]. SEEMAN, P.: Opening the dopamine D4 door. NeuroReport 7: R1-R2 (1996).
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529. SEEMAN, P.: Neurobiology of dopamine receptors, antipsychotic drugs and schizophrenia.
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531. SEEMAN, P.: Antipsychotics block type 2 and type 4 dopamine receptors. Am. Chem. Soc.
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532.[348]. NAM, D., QIAN, I.H.-P., KUSUMI, I., ULPIAN, C., TALLERICO, T., LIU, I.S.C., and
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533.[349]. LIU, I.S.C., KUSUMI, I., ULPIAN, C., TALLERICO, T., and SEEMAN, P.: A serotonin-4-
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534.[350]. SEEMAN, P., and TALLERICO, T.: Antipsychotic drugs which elicit little or no
Parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels
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535.[351]. SEEMAN, P., and MADRAS, B.K.: Anti-hyperactivity medication: methylphenidate and
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536. SEEMAN, P.: Dopamine receptors and antipsychotic drugs. Dutch Pharmacolog. Soc. (in
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537. SEEMAN, P.: Dopamine receptors and antipsychotic drugs - What makes them atypical?
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538. SEEMAN, P.: Dopamine receptors and antipsychotic drugs. Int. Fed. Pharmacy Mtng. (Aug.
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539. ZAWARYNSKI, P., LEE, S.P., TALLERICO, T., NG, G.Y.K., SEEMAN, P., O’DOWD,
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540.[352]. NG, G.Y.K., VARGHESE, G., CHUNG, H.T., TROGADIS, J., SEEMAN, P., O’DOWD,
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accompanies the up-regulation of receptors on to the surface of Sf9 cells. Endocrinology 138:
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541.[353]. SEEMAN, P.: Comment on “Positron emission tomography finding of a high striatal D2
receptor occupancy in olanzapine-treated patients.”, by A.-L. Nordström, S. Nyberg, H.
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542. SEEMAN, N., and SEEMAN, P.: Don’t legalize medical marijuana. Toronto Star, Monday,
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543.[354]. SEEMAN, P., and TAMMINGA, C.: Pruning during development. Am. J. Psychiat. 156: 168
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544. SEEMAN, P.: Dopamine Receptors. In: The molecular function and pathophysiology of the
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545. SEEMAN, P.: Schizophrenia, dopamine receptors and antipsychotic drugs. 151st Annual
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546. GEORGE, S.R., VARGHESE, G., LEE, S.P., ZEMAN, P.R., SEEMAN, P., NG, G.Y.K., and
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547. KAPUR, S., SEEMAN, P., JOYCE, J., LARUELLE, M., and BRIER, A.: The dopamine
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548.[355]. SEEMAN, P., and TALLERICO, T.: Rapid release of antipsychotic drugs from dopamine D2
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550.[357]. GEORGE, S.R., LEE, S.P., VARGHESE, G., ZEMAN, P.R., SEEMAN, P., NG, G.Y.K., and
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553.[360]. SEEMAN, P.: Antipsychotic drugs, dopamine receptors, and schizophrenia. In:
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554.[361]. SEEMAN, P., NAM, D., ULPIAN, C., LIU, I.S.C., and TALLERICO, T.: A new dopamine
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555.[362]. SEEMAN, P., and KAPUR, S.: Olanzapine binding to dopamine receptors in vitro and in
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556.[363]. SEEMAN, P., and KAPUR, S.: The dopamine receptor basis of psychosis. in: Current issues
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557. SILVESTRI, S., SEEMAN, M.V., NEGRETE, J.C., HOULE, S., SHAMMI, C.M.,
REMINGTON, G.J., KAPUR, S., ZIPURSKY, R.B., WILSON, A., CHRISTENSEN, B.K.,
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558.[364]. WADENBERG, M.-L., and SEEMAN, P.: Clozapine pretreatment enhances raclopride
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559. SILVESTRI, S., WADENBERG, M.-L., and SEEMAN, P.: Cataleptic intensity predicts the
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560. KARASINSKA, J.M., GEORGE, S.R., EL-GHUNDI, M., FLETCHER, P.J., SEEMAN, P.,
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562.[366]. KAPUR, S., and SEEMAN, P.: Antipsychotic agents differ in how fast they come off the
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563.[367]. SILVESTRI, S., SEEMAN, M.V., NEGRETE, J.-C., HOULE, S., SHAMMI, C.M.,
REMINGTON, G.J., KAPUR, S., ZIPURSKY, R.B., WILSON, A.A., CHRISTENSEN, B.K.,
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565.[369]. KAPUR, S., and SEEMAN, P.: Does Fast Dissociation From the Dopamine D2 receptor
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566. KAPUR, S., and SEEMAN, P.: Transient occupancy at the D2 receptor - A new hypothesis
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567.[370]. LIU, I.S.C., GEORGE, S.R., and SEEMAN, P.: The dopamine D2Longer receptor has a
high-affinity state and inhibits adenylate cyclase. Mol. Brain Res. 77: 281-284 (2000).
568. SEEMAN, P., and KAPUR, S.: Atypical anti-psychotics have lower affinity than dopamine
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569.[371]. LEE, D.K., LYNCH, K.R., NGUYEN, T., IM, D.-S., CHENG, R., SALDIVA, V.R., LIU, Y.,
HENG, H.H.Q., SEEMAN, P., GEORGE, S.R., O’DOWD, B.F., and MARCHESE, A.:
Cloning and characterization of additional members of the G protein-coupled receptor family.
Biochim. Biophys. Acta 1490: 311-323 (2000).
570. KAPUR, S., and SEEMAN, P.: Fast Koff at the dopamine D2 receptor (not high affinity at
other receptors) is the key to clozapine’s uniqueness and for atypical antipsychotic activity.
College Int. Neuropsychopharmacol. (Brussels) (July, 2000) (Abstract).
571.[372]. SEEMAN, P., and KAPUR, S.: Schizophrenia: More dopamine, more D2 receptors. Proc.
Nat. Acad. Sci. U.S.A. 97: 7673-7675 (2000).
572. KAPUR, S., WADENBERG. M.-L., McLELLAND, R., BARSOUM, S., BAKER, G.,
ZIPURSKY, R., and SEEMAN, P.: A low affinity at D2 receptor, NOT a high affinity at
other receptors (5HT2, D3, D4) is the reason why clozapine is an atypical antipsychotic. Soc.
Neurosci. Abstr. 26: (2000).
573.[373]. BINKLEY, K., KING, N., POONAI, N., SEEMAN, P., ULPIAN, C., and KENNEDY, J.:
Idiopathic Environmental Intolerance: Increased prevalence of panic-disorder-associated
cholecystokinin B receptor allele 7. J. Allergy Clin. Immunol. 107: 887-890 (2001).
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575.[375]. NOVAK, G., SEEMAN, P., and TALLERICO, T.: Schizophrenia: elevated mRNA for
calcium-calmodulin-dependent protein kinase IIb in frontal cortex. Mol. Brain Res. 82: 95-
100 (2000).
576. SEEMAN, P.: Schizophrenia. In: Essential Science Indicators, edited by Jennifer Minnick,
Inst. Sci. Info., Philadelphia (Nov., 2001).
578. REMINGTON, G., KAPUR, S., SHAMMI, S., and SEEMAN, P.: ‘Extended’ dosing as an
alternative to ‘intermittent’ or ‘targeted’ antipsychotic therapy: Rationale and pilot study.
Schizophrenia Res. 49 (1-2, supplement): p. 243 (2001).
579. KAPUR, S., SEEMAN, P., ZIPURSKY, R., and REMINGTON, G.J.: Fast dissociation from
the dopamine D2 receptor (not high affinity at multiple receptors) is the key to “atypical”
antipsychotics. Schizophrenia Res. 49 (1-2, supplement): p. 92 (2001).
580.[377]. KAPUR, S., BARSOUM, S.C., and SEEMAN, P.: Dopamine D2 blockade by haloperidol:
3
H-raclopride reveals much higher occupancy than EEDQ. Neuropsychopharmacology 23:
595-598 (2000).
581.[378]. KAPUR, S., and SEEMAN, P.: Ketamine has equal affinity for NMDA receptors and the
high-affinity state of the dopamine D2 receptor. Biol. Psychiatry 49: 954-957 (2001).
582.[379]. KAPUR, S., and SEEMAN, P.: NMDA antagonists ketamine and PCP have direct effects on
the dopamine D2 and serotonin 5-HT2 receptors - implications for models of schizophrenia.
Mol. Psychiat. 7: 837-844 (2002).
583. SEEMAN, P., and KAPUR, S.: Antipsychotic affinity and occupancy at dopamine D2
receptors. Int. Congress Biol. Psychiat. (Berlin; 2000).
584.[380]. KAPUR, S., McCLELLAND, R.A, VANDERSPECK, S.C., WADENBERG, M.-L.G.,
BAKER, G., NOBREGA, J., ZIPURSKY, R., and SEEMAN, P.: Increasing D2 affinity
results in the loss of clozapine’s atypical antipsychotic action. Neuroreport 13(6): 831-835
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585.[381]. KAPUR, S., and SEEMAN, P.: Reply: Does Fast Dissociation From the Dopamine D2
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586.[382]. SEEMAN, P. and KAPUR, S.: Results without regrets – Mechanism of Action of Atypical
Antipsychotics. Eur. College Neuropsychopharmacology, Istanbul, Oct. 14 (2001).
587.[383]. SEEMAN, P. and MADRAS, B.K.: Methylphenidate elevates resting dopamine which lowers
impulse-triggered release of dopamine: a hypothesis. Behavioural Brain Res. 130: 79-83
(2002).
588.[384]. SEEMAN, P.: Atypical antipsychotics: Mechanism of action. Excerpta Medica Japan. (Oct.,
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589. VANDERSPEK, S.C., NOBREGA, J., BROWNLEE, B.A, SEEMAN, P.., and KAPUR, S.:
Animal studies of antipsychotics use doses which are NOT representative of the clinical
condition - potential implications and suggested solutions. Biol. Psychiat. 51: 121S (2002).
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590.[385]. SEEMAN, P.: Atypical Antipsychotics: Mechanism of Action. Can. J. Psychiat. 47: 27-38
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591.[386]. NOVAK, G., KIM, D., SEEMAN, P.., and TALLERICO, T.: Schizophrenia and Nogo:
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592.[387]. SUN, W., GINOVART N, KO, F., SEEMAN, P.., and KAPUR, S.: In vivo evidence for
dopamine-mediated internalization of D2 receptors after amphetamine: Differential findings
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593.[388]. KAPUR, S., and SEEMAN, P.: Reply to Comment by J.H. Krystal and D.C. D’Souza on
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594.[389]. KAPUR, S., and SEEMAN, P.: Atypical antipsychotics, cortical D2 receptors and sensitivity
to endogenous dopamine. Brit. J. Psychiat. 180: 465-466 (2002).
595.[390]. KO, F., SEEMAN, P., SUN, W.S., AND KAPUR, S.: Dopamine D2 receptors internalize in
their low-affinity state. Neuroreport 13(8, June): 1017-1020 (2002).
596.[391] SEEMAN, P., TALLERICO, T., KO, F., TENN, C. AND KAPUR, S.: Amphetamine-
sensitized animals show a marked increase in dopamine D2High receptors occupied by
endogenous dopamine – even in the absence of acute challenges. Synapse 46: 235-239 (2002).
597.[392] SEEMAN, P., TALLERICO, T.: Link between dopamine D1 and D2 receptors in rat and
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598.[393] SEEMAN, M.V., and SEEMAN, P.: Choosing an antipsychotic and why. Medscape, Wed.,
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599. VANDERSPEK, S.C., BROWNLEE, B.A., NOBREGA, J., McCLELLAND, SEEMAN, P.,
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600.[394] SEEMAN, P.: The Creation of Psychopharmacology, by David Healy, Harvard University
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602. KAPUR, S., and SEEMAN, P.: Hot paper in Essential Science Indicators: “Does Fast
Dissociation From the Dopamine D2 Receptor Explain the Action of Atypical
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603.[396] SEEMAN, P. , KO, F., and TALLERICO, T.: Dopamine receptor contribution to the action
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604.[397] CHUNG, C., TALLERICO, T., and SEEMAN, P.: Schizophrenia hippocampus has elevated
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605.[398] AGID, O., SEEMAN, P. and KAPUR, S.: The ‘delayed onset’ of antipsychotic action - an
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606.[399] SEEMAN, P. , and KAPUR, S.: Anesthetics inhibit high-affinity states of dopamine D2 and
other G-linked receptors. Synapse 50: 35-40 (2003).
607. SEEMAN, P. , TALLERICO, T., and KAPUR, S.: The high-affinity state of the dopamine
D2 receptor in the action of amphetamine, anesthetics, and atypical antipsychotics. Canad.
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608.[400] SEEMAN, P. , TALLERICO, T., and KO, F.: Dopamine displaces [3H]domperidone from
high-affinity sites of the dopamine D2 receptor, but not [3H]raclopride or [3H]spiperone in
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609.[401] SEEMAN, P., and SEEMAN, M.V.: The dopamine hypothesis of schizophrenia. In:
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610.[402] SILVESTRI, S., NEGRETE, J.C., SEEMAN, M., SHAMMI, C.M., and SEEMAN, P.: Does
nicotine affect D2 receptor upregulation? A case-control study. (Acta Psychiatrica Scand.
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611.[403] GEORGE, S.R., NG, G.Y.K., LEE, S.P., FAN, T., VARGHESE, G., WANG, C., DEBER,
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dopamine transporter by a transmembrane domain peptide: Novel strategy for functional
inhibition of membrane proteins in vivo. J. Pharmacol. Exper. Therap. 307: 481-489 (2003).
612.[404] SEEMAN, P., TALLERICO, T., and KO, F.: Alcohol-withdrawn animals have a prolonged
increase in dopamine D2High receptors, reversed by general anesthesia: relation to relapse?
Synapse 52: 77-83 (2004).
613.[405] SEEMAN, P., WEINSHENKER, D., QUIRION, R., SRIVASTAVA, L., BHARDWAJ, S.K.,
GRANDY, D.K., PREMONT, R., SOTNIKOVA, T., BOKSA, P., EL-GHUNDI, M.,
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states, implying many paths to psychosis. Proc. Nat. Acad. Sci. U.S.A. 102: 3513-3518
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614.[406] SEEMAN, P.: Comment: Diverse psychotomimetics act through a common signaling
pathway. Science 305: 180 (2004).
616. SCHANK, J.R., COLE, C.D., LILES, L.C., SEEMAN, P., and WEINSHENKER, D.:
Dopamine beta-hydroxylase deficiency alters cocaine-induced locomotion and reward in
mice. Soc. Neurosci. Abstr. 30: (2004).
617.[407] SEEMAN, P., and SEEMAN, M.V.: Schizophrenia research in Canada, 1964-2004. In:
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618.[408] SEEMAN, P.: Atypical antipsychotics: Mechanism of action. Focus 2: 48-58 (2004).
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LILES, L.C., SEEMAN, P., and WEINSHENKER, D.: Dopamine β-hydroxylase knockout
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620.[410]. SEEMAN, P., SCHWARZ, J., CHEN, J.-F., SZECHTMAN, H., PERREAULT, M.,
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621.[411]. REMINGTON, G., SEEMAN, P., SHAMMI, C., MANN, S., and KAPUR, S.: “Extended”
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622. SEEMAN, P.: Convergence of multiple gene pathways to psychosis. Eur.
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623.[412]. SEEMAN, P.: An update on fast-off-D2 Atypical Antipsychotics. Am. J. Psychiat. 162:
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625. SEEMAN, P.: Getting to the source of schizophrenia. Healthcare Quart. 8: 20 (2005).
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627.[414]. SUMIYOSHI, T., SEEMAN, P., UEHARA, T., ITOH, H., TSUNODA, M., and KURACHI,
M.: Increased proportion of high-affinity dopamine D2 receptors in rats with excitotoxic
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119 (2005).
628.[415]. SEEMAN, P., and LASAGA, M.: Dopamine agonist action of phencyclidine. Synapse 58:
275-277 (2005).
629.[416]. SEEMAN, P., KO, F., WILLEIT, M., MCCORMICK, P., GINOVART, N.: Anti-Parkinson
concentrations of pramipexole and PHNO occupy dopamine D2High and D3High receptors.
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630.[417]. WILSON, A.A., McCORMICK, P., KAPUR, S., WILLEIT, M., GARCIA, A., HUSSEY, D.,
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4-propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol as a potential
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631.[418]. WILLEIT, M., GINOVART, N., KAPUR, S., HOULE, S., HUSSEY, D., SEEMAN, P., and
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632.[419]. NOVAK, G., SEEMAN, P., and TALLERICO, T.: Increased expression of
calcium/calmodulin-dependent protein kinase IIβ in frontal cortex in schizophrenia and
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633.[420] SEEMAN, P.: Dopamine receptors, schizophrenia and antipsychotics. Canad. J. Diagnosis,
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634.[421]. VASDEV, N, SEEMAN, P., GARCIA, A., STABLEFORD, W.T., NOBREGA, J., HOULE,
S., and WILSON, A.A.: Syntheses and in vitro evaluation of fluorinated naphthoxazines as
dopamine D2/D3 receptor agonists; Radiosynthesis, ex vivo biodistribution and
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635. SUMIYOSHI, T., SEEMAN, P., UEHARA, T., ITOH, H., TSUNODA, M., and KURACHI,
M.: Increased proportion of high-affinity dopamine-D2 receptors in rats with excitotoxic
damage of the entorhinal cortex: A vulnerability animal model of schizophrenia. Soc.
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636.[422]. GINOVART, N., KAPUR, S., GALINEAU L., WILLEIT, M., MIZRAHI, R., SEEMAN, P.,
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dopamine of [11C]-(+)-PHNO, a new agonist radiotracer for imaging the high-affinity state of
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637.[423]. VASDEV, N., NATESAN, S., GALINEAU, L., GARCIA, A., STABLEFORD, W.T.,
McCORMICK, P., SEEMAN, P., HOULE, S., and WILSON, AA: Radiosynthesis, in vivo and ex vivo evaluation of carbon-11 labelled (S)-(–)propyl-3-(3-hydroxyphenyl)piperidine
([11C]Preclamol) as a partial dopamine D2 receptor agonist for PET. Synapse 60: 314-318
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638.[424]. SEEMAN, P.: In session with Philip Seeman. Role of dopamine in psychopharmacology.
Primary Psychiatry 13: 37-40 (2006).
639.[425]. SEEMAN, P.: Targeting the dopamine D2 receptor in schizophrenia. Expert Opinion on
Therapeutic Targets 10: 515-531 (2006).
640.[426]. SEEMAN, P., WILSON, A, GMEINER, P., and KAPUR, S.: Dopamine D2 and D3 receptors
in human putamen, caudate nucleus, and globus pallidus. Synapse 60: 205-211 (2006).
641.[427]. KO, F., TALLERICO, T., and SEEMAN, P.: Antipsychotic pathway genes with expression
altered in opposite direction by antipsychotics and amphetamine. Synapse 60: 141-151
(2006).
642. VASDEV, N., SEEMAN, P., GARCIA, A., STABLEFORD W, HOULE S, and WILSON
AA: Syntheses and in vitro evaluation of fluorinated naphthoxazines as D2 agonists, and
radiosynthesis of [18F]FPHNO. Soc. Nucl. Med. abstr. (2006).
643.[428]. SEEMAN, P.: Dopamine receptors and antipsychotic drugs in health and disease. In Larry R.
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dopamine supersensitivity, RGS9 expression is diminished in the amphetamine-treated animal
model of schizophrenia and in post-mortem schizophrenia brain. Synapse 61: 303-309 (2007).
645.[430. WOLINSKY, T., SWANSON, C.J., SMITH, K., ZHONG, H., BOROWSKY, B., SEEMAN,
P, BRANCHEK, T., and GERALD, C.P.: The Trace Amine receptor-1 knockout mouse: an
animal model with relevance to schizophrenia. Genes, Brain and Behaviour (2006). E-Pub
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646.[431] GREENSTEIN R, NOVAK, G., and SEEMAN, P.: Amphetamine sensitization elevates
CaMKIIß mRNA. Synapse 61: 827-834 (2007).
647. McCORMICK, P.N., GINOVART, N., VASDEV, N., SEEMAN, P., KAPUR, S., and
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amphetamine challenge of [11C]-(+)-PHNO. Soc. Nucl. Med. Abstr. (2006).
648 SEEMAN, P.: Psychoses Converge via D2High Receptors. Eur. Neuropsychopharmacol. 16
(Suppl. 4): S191-S192 (2006).
649. SAMAHA, A.-N., SEEMAN, P., and KAPUR, S.: Gradual and persistent loss of the
antipsychotic efficacy of chronic haloperidol: “Breakthrough” dopamine supersensitivity
during treatment. Soc. Neurosci. Abstr. 32 (2006).
650. SEEMAN, P.: Probing the biology of psychosis, schizophrenia and antipsychotics. Medscape
interview with Jessica Gould. Online (Aug. 2006).
651.[432]. SEEMAN, P., HALL, F.S.. and UHL, G.: Increased dopamine D2High receptors in knockouts
of the dopamine transporter and the vesicular monoamine transporter may contribute to
spontaneous hyperactivity and dopamine supersensitivity Synapse 61: 573-576 (2007).
652.[433]. WILLEIT, M., GINOVART N., GRAFF, A., RUSJAN, P., VITCU, I., HOULE, S.,
SEEMAN, P., WILSON, A.A., and KAPUR, S.: First human evidence of d-amphetamine
induced displacement of a D2/3 agonist radioligand: A [11C]-(+)-PHNO positron emission
tomography study. Neuropsychopharmacology (2007, epub Apr. 4).
653.[434]. SEEMAN, P., McCORMICK, P., and KAPUR, S.: Increased dopamine D2High receptors in
amphetamine-sensitized rats, measured by the agonist [3H](+)PHNO. Synapse 61: 263-267
(2007).
654.[435]. SEEMAN, P.: Anti-Parkinson therapeutic potencies correlate with their affinities for
dopamine D2High receptors. Synapse 61: 1013-1018 (2007).
655.[436]. SEEMAN, P., CARUSO, C., M. LASAGA: Memantine agonist action at dopamine D2High
receptors. Synapse 62: 149-153 (2008).
656. SAMAHA, A.-N., SEEMAN, P., STEWART, J., RAJABI, H., and KAPUR, S.: Chronic
haloperidol gradually and persistently loses its antipsychotic efficacy over time: Pre- and
post-synaptic changes in dopamine function during treatment. Int. Congr. Schizophrenia
(2007) Abstract.
657.[437]. SHUTO, T., SEEMAN, P., KUROIWA, M., NISHI, A.: Repeated administration of a
dopamine D1 receptor agonist reverses the increased proportions of striatal dopamine D1High
and D2High reeptors in methamphetamine-sensitized rats. Eur. Neuropsychopharmacol. (2008,
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658.[438]. GRAFF-GUERRO, A., WILLEIT, M., GINOVART, N., MAMO, D., MIZRAHI, R.,
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binding of the D2/3 agonist [11C]-(+)-PHNO and the D2/3 antagonist [11C]raclopride in healthy
humans. Human Brain Mapping 29(4): 400-410 (2008).
659.[439]. SEEMAN, P., and GUAN, H.-C.: Dopamine partial agonist action of (-)OSU6162 is
consistent with dopamine hyperactivity in psychosis. Eur. J. Pharmacol. 557: 151-153 (2007).
660.[440]. TASSIN, J.-P., TORRENS, Y., SALOMON, L., LANTERI, C., and SEEMAN, P.: Elevated
dopamine D2High receptors in alpha-1beta-adrenoceptor knockout supersensitive mice.
Synapse 61: 569-572 (2007).
661.[441]. SEEMAN, P. , CARUSO, C., and LASAGA, M.: Dopamine partial agonist actions of the
glutamate receptor agonists LY 354,740 and LY 379,268. Synapse 62: 154-158 (2008).
662.[442]. PERREAULT, M.L, SEEMAN, P. and SZECHTMAN, H.: Kappa-opioid receptor
stimulation quickens pathogenesis of compulsive checking in the quinpirole sensitization
model of obsessive-compulsive disorder (OCD). Behav. Neurosci. 121: 976-991 (2007).
663.[443]. SAMAHA, A.-N., SEEMAN, P., STEWART, J., RAJABI, H., and KAPUR, S.:
“Breakthrough” dopamine supersensitivity during ongoing antipsychotic treatment leads to
failure over time. J. Neurosci. 27: 2979-2986 (2007).
664. SEEMAN, P.: Comments on the publication of Zhao et al. Schizophrenia Res. Forum.
http://www.schizophreniaforum.org/new/detailprint.asp?id=1304
666. BYMASTER, F., & SEEMAN, P.: Pre-clinical pharmacology of olanzapine. (Unpublished).
667.[444]. SEEMAN, P.: Dopamine D2High receptors moderately elevated by sertindole. Synapse 62:
389-393 (2008).
668.[445]. McCORMICK, P.N., KAPUR, S., SEEMAN, P., and WILSON, A.A.: Dopamine D2
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670. SAMAHA, A.-N., RECKLESS, G.E., SEEMAN, P., and KAPUR, S.: Continuous but not
intermittent haloperidol treatment leads to dopamine supersensitivity and a progressive loss in
antipsychotic efficacy. “50 Years of dopamine”. Gotenberg, Sweden (2007). Abstract.
671.[446]. SEEMAN, P.: Dopamine and Schizophrenia. Scholarpedia, 2(10):3634 (2007).
672. SAMAHA, A.-N., RECKLESS, G.E., SEEMAN, P., and KAPUR, S.: Maintaining
continuous but not transient therapeutic brain levels of antipsychotic leads to dopamine
supersensitivity and an enduring loss of antipsychotic efficacy. Soc. Neurosci. Abstr. (2007).
673. SHUTO, T., KUROIWA, SEEMAN, P., and NISHI, A.: Repeated administration of
dopamine D1 receptor agonist reverses the increased proportion of high-affinity dopamine D1
and D2 receptors in methamphetamine-sensitized rats. Soc. Neurosci. Abstr. (2007).
674.[447]. SEEMAN, P.: All psychotic roads lead to increased D2High dopamine receptors. A
perspective. Clin. Schizophrenia and Related Psychoses Jan., 2008: 351-355.
675.[448]. SIMOLA, N., MORELLI, M., and SEEMAN, P.: Increase of dopamine D2High receptors in
the striatum of rats sensitized to caffeine motor effects. Synapse 62: 394-397 (2008).
676.[449] SEEMAN, P.: Dopamine D2High receptors on intact cells. Synapse 62: 314-318 (2008).
677.[450]. BRIAND, L.A., FLAGEL, S.B, SEEMAN, P., ROBINSON, T.E.: Cocaine self-
administration produces a persistent increase in dopamine D2High receptors. Eur. J.
Neuropsychopharmacol. (2008) Epub Feb. 18, 2008.
679.[452]. SEEMAN, P.: Dopamine D2High receptors moderately elevated by bifeprunox and
aripiprazole. Synapse (2008, in press).
681.[454]. SEEMAN, P.: Dopamine D2High receptors measured ex vivo are elevated in amphetamine-
sensitized animals. Synapse (2008).
682.[455]. SEEMAN, P: Glutamate agonists for schizophrenia stimulate dopamine D2High receptors
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683.[456]. SEEMAN, P.: Historical Introduction to The Dopamine Receptors. In: The Dopamine
Receptors, edited by K. Neve, Humana Press (2008, in press).
684. KING, M., SEEMAN, P., MARSDEN, C. FONE, K.C.F.: Increased dopamine D2High
receptors in rats reared in social isolation, an animal model of schizophrenia. Brit. Pharmacol.
Soc. (2007), abstract.
685.[457]. SAMAHA, A.-N., RECKLESS, G., SEEMAN, P., DIWAN, M., NOBREGA, J.N., KAPUR,
S.: Less is More: Antipsychotic drug effects are greater with transient rather than continuous
delivery. Biol. Psychiatry (2008, in press). Epub Feb 22, 2008.
686. SEEMAN, P.: Comments on Minnesota Consensus Group document (A. MacDonald et al.)
on What we Know…What we don’t know about schizophrenia.
http://www.schizophreniaforum.org/whatweknow/newssearch.asp?categoryID=24&type=all
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