Biographical Sketch
Dr. Lee received his M.D. from the Faculty of Medicine at the University of Toronto in 1997 and was awarded the Cody Gold Medal. He completed residencies in Internal Medicine, Respirology, and Critical Care Medicine in Toronto. He then undertook research training in the Programme in Cell Biology at the Hospital for Sick Children in the laboratory of Dr. Sergio Grinstein, completing a PhD in 2006. This was followed by postdoctoral training in Microbiology and Immunology at Weill Medical College of Cornell University (New York, NY) in the laboratory of Dr. Carl F. Nathan.
University Appointments
Assistant Professor, Department of Medicine, University of Toronto
Hospital Appointments
Staff Physician, Department of Critical Care, St. Michael's Hospital
Clinical Activities
Critical Care Medicine (10 weeks a year) - St. Michael's Hospital
Educational Activities
Faculty, Respiratory Physiology Course for Respirology Fellows, University of Toronto
Research Interests
Regulation and pertubation of endothelial permeability during inflammation
Selected Recent Publications
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Chapters and Monographs
Lee WL, Slutsky AS. Acute Respiratory Distress Syndrome. Chapter 90 in Textbook of Respiratory Medicine 5/e, Editors Murray/Nadel/Choi. 2009 (book chapter, in press)
Update in critical care 2008. Fowler RA, Adhikari NK, Scales DC, Lee WL, Rubenfeld GD. Am J Respir Crit Care Med. 2009 May 1;179(9):743-58.
Update in critical care 2007. Fowler RA, Adhikari NK, Scales DC, Lee WL, Rubenfeld GD. Am J Respir Crit Care Med. 2008 Apr 15;177(8):808-19.
Lee WL, Ferguson ND. SOAP and sepsis - analyzing what comes out in the wash. Critical Care Medicine 2006;2:552-554 (invited editorial)
Lee WL, Slutsky AS. Hypoxemic respiratory failure, including ARDS. Chapter 85 in Textbook of Respiratory Medicine 4/e, Editors Murray/Nadel/Mason/Broaddus. 2005.
Lee WL, Grinstein S. The tangled webs that neutrophils weave. Science 2004; 303:1477-78. (invited editorial)
Lee WL, Harrison R, Grinstein S. Phagocytosis in neutrophils. Microbes and Infection 2003;5:1299-1306. (review)
Lee WL, Downey GP. ICU Cornerstone: Changing our view of blood transfusions. Critical Care Forum 2002, 6:291-292.
Lee WL, Stewart TES. Evaluation of lung protective ventilation strategies in ARDS. European Respiratory Monograph 2002;20, 195-207. (review)
Lee WL, Downey GP. The role of leukocytes in sepsis and lung injury. In Evans TW, Fink MP (Eds.), Update in intensive care and emergency medicine: Mechanisms of Organ Dysfunction in Critical Illness. Heidelberg. Springer Verlag 2002;95-109. (book chapter)
Lee WL, Downey GP. Leukocyte Elastase: Physiological Functions and Role in Acute Lung Injury. A State of the Art Review. American Journal of Respiratory and Critical Care Medicine 2001;164:896-904.
Lee WL, Downey GP. Neutrophil activation in acute lung injury. Current Opinion in Critical Care 2001;7:1-7.
Lee WL, Slutsky AS. Ventilator-induced lung injury. Seminars in Respiratory and Critical Care Medicine 2001;22:269-280. (review)
Lee WL, Downey GP. The role of neutrophils in acute lung injury. In " Etiology and Treatment of Acute Lung Injury: from bench to bedside". Editors: Sadis Matalon and Jacob I. Sznajder. NATO ASI Series, IOS press BV, Amsterdam, Netherlands pp 124-131,2001. (book chapter)
Lee WL, Ball C. Hyperkalemia. In: Ball CM, Phillips RS, (Eds). Evidence-based on call - Acute Medicine. London: Churchill Livingstone, 2001; 334-339. (book chapter)
Lee WL, Downey GP. Coagulation inhibitors in sepsis and disseminated intravascular coagulation. Intensive Care Medicine 2000;26:1701-1706.
Lee WL, Detsky AS. Stewart TES. Lung-protective ventilation in ARDS. Intensive Care Medicine 2000;26:1151-1155.
Lee WL, Zinman B: From insulin to insulin analogs: progress in the treatment of type 1 diabetes mellitus. Diabetes Reviews 1998;6:73-88. (review)
Research Laboratory
warrenleelab.com
Keenan Research Centre in the Li Ka Shing Knowledge Institute,
St. Michael's Hospital
30 Bond Street
Toronto, Ontario, M5B 1W8
Office Location:
209 Victoria Street, 6th Floor, Room 613
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