|
||
Biographical SketchDr. Chow completed medical school at the University of Toronto, where she complete clinical training in General Internal Medical and Adult Respiratory Medicine. She pursued graduate studies in Cell Biology under the mentorship of Dr. Sergio Grinstein at the Hospital for Sick Children, University of Toronto and obtained her PhD in 1999. She did post-doctoral training at the Max Planck Institute in Germany as an Alexander von Humboldt fellow and with Dr. Gregory Downey at the University of Toronto. Dr. Chow is currently appointed as Clinician-Scientist, Assistant Professor in the Multi-Organ Transplant Programme, Division of Respirology, Department of Medicine. She divides her time between a clinical focus in lung transplantation, and research in the basic mechanisms that regulate airway inflammation and remodeling with a specific interest in the role of the Syk tyrosine kinase in the airway epithelia. There are two major themes of research in Dr. Chow's laboratory. The first is focused on underlying the role and regulation of Syk mediating airway inflammation following exposure to human rhinovirus (the most common cause of acute infections in humans and the cause of the common cold) and in response to environmental air pollution. The second theme focuses on the role of Syk in modulating tissue repair and airway remodeling, a common feature in chronic lung diseases such as asthma, chronic obstructive lung disease and graft rejection following lung transplantation. Research is carried out in vitro using mono- and co-cultures of airway epithelial and airway smooth muscle cells, and in vivo using several animal models of allergen-induced asthma and real-time exposure to environmental airway pollution. University AppointmentsAssistant Professor, Department of Medicine, University of Toronto Hospital AppointmentsStaff Physician, Division of Respirology and Multi-Organ Transplant Programme, University Health Network, University of Toronto Clinical ActivitiesLung Transplantation Educational ActivitiesCurrently accepting research fellows and graduate students Current Local, Provincial, National and International ActivitiesAmbassador Scientist: Alexander von Humboldt Foundation, Germary Research InterestsRegulation of airway epithelial cell response to respiratory viruses and environmental air pollution
Role of airway epithelial cell signaling in graft dysfunction following lung transplantation Current Grant SupportCanadian Institutes for Health Research Previous Grant Support Selected Recent PublicationsClick here for search results from PubMed http://www.socaar.utoronto.ca/about.htm Chapters and MonographsC.W. Chow and G.P. Downey. Inflammation. In Clinical Critical Care Medicine. Editors: Richard K Albert, Arthur Slutsky, Marco Ranieri, Jukka Takala, Antonio Torres. Elsevier USA. C.W. Chow, G.P. Downey and S. Grinstein. Measurements of phagocytosis and phagosomal maturation. In Current Protocols in Cell Biology. Lippinchott-Schwartz J, Dasso M, Harford J, Yamada J and Bonifacino JS (Eds.) John Wiley and Sons USA 2004. C.W. Chow, M.T. Herrera Abreu, T. Suzuki and G. P. Downey. Oxidative Stress and Acute Lung Injury. American Journal of Respiratory Cell and Molecular Biology. 29: 427-431; 2003 (Cover article). |