ENDOCRINOLOGY AND DIABETES RESEARCH GROUP
EDRG LABORATORY INVESTIGATORS
AND FOCUS
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Resources and Research Focus


 

The EDRG consists of 75 principal researchers, post-doctoral fellows, technicians and graduate students.  The group has at its disposal state-of-the-art methods and  equipment for the pursuit of its studies.

 Current Research Focus

  • The roles of carbohydrate and lipid metabolism in the pathology of diabetes
  • Receptor protein structure and crystallography and ligand design
  • Intestinal growth factors, receptors and signal transduction
  • Fetal programming of the hypothalamo-pituitary-adrenocortical (HPA) axis
  • Changes in HPA axis development associated with Type 1 and Type 2 diabetes    
  •  Electrophysiological studies of beta cell ion channels and the development of drugs that target these channels
  • Molecular mechanisms of insulin exocytosis
  • Microencapsulation technology and islet cell and pancreas transplantation
  • Mechanisms of insulin resistance and targets for therapy
  • Molecular mechanisms contributing to insulin sensitivity, and the study of insulin sensitizer drugs

 Current Methods and Resources

The University of Toronto, Canada’s premier University contains cutting-edge resources and equipment needed for the  studies performed by the EDRG.  Several core facilities at the University and surrounding Hospitals are at the disposal of the EDRG including a full range central labs for diagnostic studies and genetic screening.  Some of the core labs include  transgenic and gene knockout facilities, cell imaging/ microscopy and signal transduction labs and a protein structure facility. The EDRG also contains a core pancreatic beta cell research program shared by M. Wheeler, H.Y, Gaisano, A.M. Salapatek, and A.M. Sun.  This core lab is capable of a wide range of studies on the beta cell including  isolation, growth , transplantation, targeted gene therapy, molecular biology and electrophysiology.  The lab is ideally set-up for academic and industry partnering projects.

INNOVATIVE MEDICAL RESEARCH

SCIENTIFIC AND
CLINICAL TRAINING PROGRAMS

INDUSTRY UNIVERSITY PARTNERING

CLINICAL
TRIAL CENTRE


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