A two-photon image taken from a lamina I neuron that was filled with lucifer yellow (0.1%, green) during whole-cell recording.

GluN2B and GluN2D NMDA receptors dominate synaptic responses in the spinal cord

Recent research by the Salter lab at The Hospital for Sick Children has demonstrated that excitatory synaptic transmission of lamina I neurons in the spinal cord of rats differs significantly from the rest of the CNS.  The authors show that synaptic responses in lamina I neurons tend to be more prolonged than synaptic responses elsewhere in the CNS.

Cognitive-behavioural therapy reduces our pain experience

Researchers at Toronto Western Hospital have uncovered empirical evidence that developing coping mechanisms not only helps people manage pain, but actually reduces the unpleasantness of the pain experience.

Mind Wandering Engages Pain-Relieving Pathways in the Brain

Everyone has experienced instances of their mind wandering away from tasks at hand. Recent evidence from UTCSP trainee Aaron Kucyi, in Dr. Karen Davis’ lab at Toronto Western Hospital, demonstrates that our minds wander even during pain, and that this is associated with increased engagement of pain-relieving pathways.

Novel Role of Gap Junctions Identified in Trigeminal Neuropathic Pain

This study provides the first evidence indicating a role of gap junctions in trigeminal neuropathic pain. Whether these gap junctions are specific to glia requires further investigation. Given that carbenxolone is already used for the clinical treatment of ulcers, it has the potential to be a safe and effective drug for the clinical treatment of trigeminal neuropathic pain. Therefore, investigation of the efficacy of carbenxolone in treating pain in humans is necessary.