UTCSP News
2013 UTCSP Annual Scientific Meeting: a success!
Researchers, clinicians, educators, and students gathered at the 2013 UTCSP Annual Scientific Meeting on February 26. (click on link for full review)
Steven P. Miller, Brain Development in the Preterm Newborn: the Importance of the Everyday
2012 The Hospital for Sick Children Research Institute 25th Annual Scientific Retreat, November 8, 2012
Commentary by lead author Simon Beggs on his recent paper: Beggs S, Alvares D, Moss A, Currie G, Middleton J, Salter MW, Fitzgerald M. "A role for NT-3 in the hyperinnervation of neonatally wounded skin" Pain 2012 Oct;153(10):2133-9.
UTCSP resesearchers have identified a possible mechanism by which early-life injuries can result in subsequent pain. The study, published in the October 2012 issue of Pain, was conducted by Dr. Simon Beggs in collaboration with researchers at Sickkids Hospital and University College London, UK.
Congratulations!
Congratulations to the following UTCSP members who are recipients of 2013 Canadian Pain Society Awards:
Distinguished Career Award 2013 — Joel Katz
Early Career Award 2013 — Michael McGillion
Excellence in Interprofessional Pain Education Award — Judith Hunter
Pain Mentorship Award — Barry Sessle
Distinguished Career Award 2013 — Joel Katz
Early Career Award 2013 — Michael McGillion
Excellence in Interprofessional Pain Education Award — Judith Hunter
Pain Mentorship Award — Barry Sessle
Combining Brain Imaging Technologies and Behavioural Studies to Better Understand Pain
Dr. Karen Davis is a senior scientist and heads the Division of Brain, Imaging & Behaviour Systems at Toronto Western Research Institute. She is cross-appointed as a professor in the Department of Surgery and the associate director for the Institute of Medical Science at the University of Toronto. Dr. Tim Salomons is one of her post-doctoral fellows. Together they are combining their expertise in MR-based technologies and behavioural and psycho-physical studies to better understand pain.
Events
Mechanisms in Neuropathic Pain: Insights From Animal and Human Research
A Tribute to Jonathan O. Dostrovsky
Satellite Symposia
4th International Congress on Neuropathic Pain
May 22, 2013
Metro Toronto Convention Centre
Satellite Symposia
4th International Congress on Neuropathic Pain
May 22, 2013
Metro Toronto Convention Centre
Peripheral Neuropathic Pain: Unravelling Mechanisms for Individualized Pharmacotherapy
Presented by the Leslie Dan Faculty of Pharmacy
Featuring guest speaker Simon Haroutounian, PhD, Clinical Pharmacy Specialist, Post Doctoral Research Fellow, Aarhus University Hospital, Danish Pain Research Centre, Denmark
May 24, 2013
9:00 a.m. to 10:00 a.m.
Room 850, Leslie Dan Faculty of Pharmacy
144 College Street Toronto
All are welcome to attend. Light refreshments will be served.
Featuring guest speaker Simon Haroutounian, PhD, Clinical Pharmacy Specialist, Post Doctoral Research Fellow, Aarhus University Hospital, Danish Pain Research Centre, Denmark
May 24, 2013
9:00 a.m. to 10:00 a.m.
Room 850, Leslie Dan Faculty of Pharmacy
144 College Street Toronto
All are welcome to attend. Light refreshments will be served.
10th Annual Pain Day Event - Chronic Pain Service Integration - A Viable Roadmap
This is a multidisciplinary conference featuring leading experts in chronic pain management
Date: Friday, June 21, 2031
Location: Kingston Waterfront Hotel, Kingston, Ontario
For further details, click on the LINK
Date: Friday, June 21, 2031
Location: Kingston Waterfront Hotel, Kingston, Ontario
For further details, click on the LINK
Pain in the News
May 19, 2013
Voluntary movements as a possible non-reflexive pain assay
The quantification of pain intensity in vivo is essential for identifying the mechanisms of various types of pain or for evaluating the effects of different analgesics. A variety of behavioral tests for pain measurement have been devised, but many are limited because animals are physically restricted, which affects pain sensation.
May 12, 2013
TGF-beta1 sensitizes TRPV1 through Cdk5 signaling in odontoblast-like cells
Odontoblasts are specialized cells that form dentin and they are believed to be sensors for tooth pain. Transforming growth factor-beta1 (TGF-beta1), a pro-inflammatory cytokine expressed early in odontoblasts, plays an important role in the immune response during tooth inflammation and infection.
May 1, 2013
Phospholipase C-related but catalytically inactive protein modulates pain behavior in a neuropathic pain model in mice
An inositol 1,4,5-trisphosphate binding protein, comprising 2 isoforms termed PRIP-1 and PRIP-2, was identified as a novel modulator for GABAA receptor trafficking. It has been reported that naive PRIP-1 knockout mice have hyperalgesic responses.FindingsTo determine the involvement of PRIP in pain sensation, a hind paw withdrawal test was performed before and after partial sciatic nerve ligation (PSNL) in PRIP-1 and PRIP-2 double knockout (DKO) mice.
Apr 28, 2013
Sodium-calcium exchangers in rat trigeminal ganglion neurons
Noxious stimulation and nerve injury induce an increase in intracellular Ca2+ concentration ([Ca2+]i) via various receptors or ionic channels. While an increase in [Ca2+]i excites neurons, [Ca2+]i overload elicits cytotoxicity, resulting in cell death.
Apr 17, 2013
Peripheral nerve injury is accompanied by chronic transcriptome-wide changes in the mouse prefrontal cortex
Peripheral nerve injury can have long-term consequences including pain-related manifestations, such as hypersensitivity to cutaneous stimuli, as well as affective and cognitive disturbances, suggesting the involvement of supraspinal mechanisms. Changes in brain structure and cortical function associated with many chronic pain conditions have been reported in the prefrontal cortex (PFC).