Cognitive-behavioural therapy reduces our pain experience

Researchers at Toronto Western Hospital have uncovered empirical evidence that developing coping mechanisms not only helps people manage pain, but actually reduces the unpleasantness of the pain experience.
A two-photon image taken from a lamina I neuron that was filled with lucifer yellow (0.1%, green) during whole-cell recording.

GluN2B and GluN2D NMDA receptors dominate synaptic responses in the spinal cord

Recent research by the Salter lab at The Hospital for Sick Children has demonstrated that excitatory synaptic transmission of lamina I neurons in the spinal cord of rats differs significantly from the rest of the CNS.  The authors show that synaptic responses in lamina I neurons tend to be more prolonged than synaptic responses elsewhere in the CNS.

UTCSP Members Make Toronto Life's Top 30 List of Best Doctors in Toronto!

Congratulations to Allan Gordon (Pain Medicine) and John Flannery (Physiatry) for being recognized by Toronto Life Magazine as being the best in your field.

Bonnie Stevens to receive CPS Distinguished Career Award

The Canadian Pain Society (CPS) has named Dr. Bonnie Stevens as the recipient of its Distinguished Career Award.  The Award will be presented at the annual meeting of CPS in Quebec City May 20-23. Award recipients are honored at a dinner May 22, and Dr. Stevens will present on her work at the meeting.

Mind Wandering Engages Pain-Relieving Pathways in the Brain

Everyone has experienced instances of their mind wandering away from tasks at hand. Recent evidence from UTCSP trainee Aaron Kucyi, in Dr. Karen Davis’ lab at Toronto Western Hospital, demonstrates that our minds wander even during pain, and that this is associated with increased engagement of pain-relieving pathways.


Pain Interprofessional Curriculum Design


Pain Interprofessional Curriculum Design (PICD) Workshop
hosted by the University of Toronto Centre for the Study of Pain
in association with the University of Toronto Centre for Interprofessional Education
November 12-14, 2014

Mark Your Calendars!

UTCSP Annual Scientific Meeting 2015
co-sponsored with the Hospital for Sick Children's Pain Centre
Tuesday, February 10, 2015
8:00 a.m. to 1:30 p.m.
Peter Gilgan Centre for Research & Learning
Classroom 2a,b and Gallery, 686 Bay Street
The Hospital for Sick Children

35th Annual Scientific Meeting of the Canadian Pain Society

May 20-23, 2014
Quebec City

The CPS is a multiprofessional society of basic scientists, clinician scientists, and health professionals who are interested in improving pain management for people across the lifespan.
Further information can be found at the CPS Website

Keystone Symposia on Molecular and Cellular Biology

The Brain: Adaptation and Maladaptation in Chronic Pain
June 15-20, 2014

Keystone Resort, Keystone, Colorado, USA
For more information regarding registration, important deadlines, and to view the full program, please follow the LINK

How to Navigate Difficult Medical Conditions

11th Annual Pain Day Event
This is a multidiscplinary conference featuring leading experts in chronic pain
June 20, 2014
Delta Waterfront Hotel
Kingston, Ontario

For complete details and to register, click on the following LINK


15th World Congress on Pain

Presented by the International Association for the Study of Pain (IASP)
October 6 - 11, 2014
Buenos Aires

For further details, please visit the IASP website by clicking on the following LINK

Global Year Against Orofacial Pain - October 2013 - October 2014

For More Information

Pain in the News

Apr 15, 2014

A simplified up-down method (SUDO) for measuring mechanical nociception in rodents using von Frey filaments

The measurement of mechanosensitivity is a key method for the study of pain in animal models. This is often accomplished with the use of von Frey filaments in an up-down testing paradigm.
Apr 11, 2014

Contrasting alterations to synaptic and intrinsic properties in upper-cervical superficial dorsal horn neurons following acute neck muscle inflammation

Acute and chronic pain in axial structures, like the back and neck, are difficult to treat, and have incidence as high as 15%. Surprisingly, most preclinical work on pain mechanisms focuses on cutaneous structures in the limbs and animal models of axial pain are not widely available.
Apr 8, 2014

The chemerin receptor 23 agonist, chemerin, attenuates monosynaptic C-fibre input to lamina I neurokinin 1 receptor expressing rat spinal cord neurons in inflammatory pain

Recent evidence has shown that the chemerin receptor 23 (ChemR23) represents a novel inflammatorypain target, whereby the ChemR23 agonists, resolvin E1 and chemerin, can inhibit inflammatory painhypersensitivity, by a mechanism that involves normalisation of potentiated spinal cord responses.This study has examined the ability of the ChemR23 agonist, chemerin, to modulate synaptic inputto lamina I neurokinin 1 receptor expressing (NK1R+) dorsal horn neurons, which are known to becrucial for the manifestation of inflammatory pain. Whole-cell patch-clamp recordings from pre-identified lamina I NK1R+ neurons, in rat spinal cordslices, revealed that chemerin significantly attenuates capsaicin potentiation of miniature excitatorypostsynaptic current (mEPSC) frequency, but is without effect in non-potentiated conditions.
Apr 2, 2014

Retraction: Comparison of central versus peripheral delivery of pregabalin in neuropathic pain states

No description available
Mar 24, 2014

The effect of acupuncture needle combination on central pain processing-an fMRI study

Empirical acupuncture treatment paradigm for acute pain utilizing Tendinomuscular Meridians (TMM) calls for the stimulation of Ting Points (TPs) and Gathering point(GP). This study aims to compare the supraspinal neuronal mechanisms associated with both TPs and GP needling (EA3), and TPs needling alone (EA2) with fMRI.