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Robert G. Josse M.D., F.R.C.P.(C)
Professor
Tel: (416) 867 7455 |
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Research
Often with an emphasis in clinical nutrition, I have obtained peer review and non peer review grants (mostly Phase II and III pharmaceutically funded multicentre national and international studies) as Principal, Co-principal or Co-investigator. These studies have investigated the effects of various new drugs on diabetes control, hyperlipidemia and prevention and treatment of diabetes complications. I have been particularly interested in the nutritional management of diabetes with other colleagues in the Department (Jenkins, Wolever). We have promulgated the concept of the glycemic index of foods and the importance of meal frequency as therapeutic principles.
We have promulgated the concept of the glycemic index of foods and the importance of meal frequencies as diabetic principles. Metabolic bone disease research, principally osteoporosis, revolves around phase II and III drug studies for the treatment of osteoporosis and other metabolic bone diseases. Much of this work is multinational, multicentre investigations, but I also conduct other epidemiologic and clinical studies in disorders of calcium metabolism and metabolic bone disease.
Selected Publications
Lentle BC, Brown JP, Khan AA, Leslie WD, Levesque J, Lyons DJ, Siminoski K, Tarulli G, Josse RG, Hodsman AB. Recognizing and Reporting Vertebral Fractures: Reducing the Risk of Future Osteoporotic Fractures. Can Assoc Radio J 2007 Feb:312-321.
Cranney A, Jamal SA, Tsang JF, Josse RG, Leslie WD. Low bone mineral density and fracture burden in postmenopausal Canadian women. CMAJ 9/11/2007;177(6):575‑580; DOI: 10.1503/cmaj.070234; (AN 26595523).
Richards JB, Leslie WD, Joseph L, Siminoski K, Hanley DA, Adachi JD, Brown JP, Morin S, Papaioannou A, Josse RG, Prior JC, Davison KS, Tenenhouse A, Goltzman D for the CaMos Study Group. Changes to Osteoporosis Prevalence According to Method of Risk Assessment. J Bone Miner Res 2007;22:228-234. Published online on November 13, 2006; doi: 10.1359/JBMR.061109.
Richards JB, Papioannou A, Adachi JD, Joseph L, Whitson HE, Prior JC, Goltzman D, CaMos Research Group. Effect of Selective Serotonin Reuptake Inhibitors on the Risk of Fracture. Arch Intern Med 2007 Jan 22;167(2):188-94.
Rao LG, Mackinnon ES, Josse RG, Murray TM, Strauss A, Rao A. Lycopene Consumption Significantly Decreases Oxidative Stress and Bone Resorption Markers in Postmenopausal Women at Risk for Osteoporosis. Osteoporosis Int 2007 Jan;18(1):109-115.
Richards JB, Leslie W, Joseph L, Siminoski K, Hanley D, Adachi JD, Brown J, Morin S, Papioannou A, Josse RG, Prior J, Davison KS, Tenenhouse A, Goltzman D. Changes to osteoporosis prevalence according to method or risk assessment. JBMR 2007 Feb;22(2):228-34.
Josse RG. Roles for estrogen in bone loss and arthralgia during aromatase inhibitor treatment. Current Opinions in Oncology 2007 April 19 Suppl 1:S1-S8.
Jenkins DJA, Kendall CWC, Nguyen T, Teitel J, Marchie A, Taha A, Faulkner DA, Kemp T, Wong JMW, de Souza R, Emam A, Vidgen E, Trautwein EA, Lapsley KG, Holmes C, Josse RG, Leiter LA, Connelly PW, Singer W. Effect on Hematologic Risk Factors for Coronary Heart Disease of a Cholesterol Reducing Diet. Eur J Clin Nutr (01 Apr 2007) 61;483-492.
Jenkins DJA, Kendall CWC, Faulkner DA, Kemp T, Marchie A, Nguyen TH, Wong JMW, de Souza R, Emam A, Vidgen E, Trautwein EA, Lapsley KG, Josse RG, Leiter LA, Singer W. Long-term effects of a plant-based dietary portfolio of cholesterol-lowering foods on blood pressure. Eur J Clin Nutr (25 Apr 2007).
Hopman WM, Leroux C, Berger C, Joseph L, Barr SI, Prior JC, Harrison M, Poliquin S, Towheed T, Anastassiades T, Goltzman D, CaMos Research Group. Changes in body mass index in Canadians over a five-year period: Results of a prospective, population-based study. BMC Public Health 2007 Jul 9;7:150.
Fontaine-Bisson B, Wolever TMS, Chiasson J-L, Rabasa-Lhoret R, Maheux P, Josse RG, Leiter LA, Rodger NW, Ryan EA, Corey PN, El-Sohemy A. Genetic polymorphisms of TNF-α modify the association between dietary polyunsaturated fatty acids and fasting serum concentrations of HDL-C and Apo A-I in individuals with type 2 diabetes. Am J Clin Nutr Sep 2007;86:768 – 774.
Prior JC, Burdge DR, Maan E, Milner R, Hankins C, Klein M, Walmsley S, Canadian Women’s HIV Study Group, CaMos Research Group. Fragility fractures and bone mineral density in HIV positive women: A case control population-based study. Osteoporosis Int 2007 Oct 18(10):1345-53. [Epub 2007 Jul 31].
Khan AA, Colquhoun A, Hanley DA, Jankowski LG, Josse RG, Kendler DL, Lentle B, Leslie WD, Lewiecki EM, O'Neill E, Robertson S, Syed ZA, Tanner B, Webster D. Standards and Guidelines for Technologists Performing Central Dual-Energy X-Ray Absorptiometry. J Clin Densitom 2007;10(2):189-195.
Siminoski K, Leslie WD, Frame H, Hodsman A, Josse RG, Khan A, Lentle BC, Levesque J, Lyons DJ, Tarulli G, Brown JP. Recommendations for Bone Mineral Density Reporting in Canada: A Shift to Absolute Fracture Risk Assessment. J Clin Densitom 2007;10(2):120-123.
Fontaine-Bisson B, Wolever TMS, Chiasson J-L, Rabasa-Lhoret R, Maheux P, Josse RG, Leiter LA, Rodger NW, Ryan EA, El-Sohemy A. TNF-α – 238g>A genotype alters post-prandial plasma levels of free fatty acids in obese individuals with type 2 diabetes. Metabolism 2007;56:649-655.
Sawka AM, Ray J, Yi Q, Josse RG, Lonn E. Randomized Clinical Trial of Homocysteine Level-Lowering Therapy and Fractures. Arch Intern Med, Oct 2007;2136-2139.
Josse RG, Hanley DA, Kendler D, Ste‑Marie L-G, Adachi JD, Brown J. Diagnosis and Treatment of Paget’s Disease of Bone. Clin Invest Med 2007;30(5):E210-E223.
Papaioannou A, Kennedy CC, Ioannidis G, Berger C, Sawka A, Goltzman D, Tenenhouse A, Pickard L, Olszynski W, Davison KS, Kaiser S, Josse RG, Hanley DA, Prior JC, Brown JP, Anastassiades T, Adachi JD, and the CaMos Research Group. The Osteoporosis Caregap in Men with Fragility Fractures. Osteoporosis Int 2007 Oct 9 [Epub ahead of print]. (4):581-587.
Chong CAKY, Diaz-Granados N, Hawker GA, Jamal S, Josse RG, Cheung AM. Complementary and Alternative Medicine Use by Osteoporosis Clinic Patients. Osteoporosis Int Nov 2007;18(11):1547-1556.
Wolever TMS, Gibbs AL, Mehling C, Chiasson J-L, Connelly PW, Josse RG, Leiter LA, Maheux P, Rabasa-Lhoret R, Rodger NW, Ryan EA. CCD (Canadian trial of Carbohydrates in Diabetes), One year controlled trial of low glycemic index dietary carbohydrate in type 2 diabetes: No effect on HbA1c but reduced C‑reactive protein. Am J Clin Nutr 2008 Jan ;87 (1):114-25.
Jenkins DJA, Kendall CWC, Nguyen TH, Marchie A, Faulkner DA, Josse AR, Vidgen E, Trautwein EA, Kapsley KG, Holmes C, Josse RG, Leiter LA, Connelly PW and Singer W. Effect of plant sterols in combination with other cholesterol-lowering foods. Metabolism 2008 Jan 57;1: 130-139.
Wolever TMS, Mehling C, Chiasson J-L, Josse RG, Leiter LA, Maheux P, Rabasa‑Lhoret r,Rodger NW,Ryan EA. Low glycemic-index diet and disposition index in type 2 diabetes (the Canadian trial of Carbohydrates in Diabetes): a randomized controlled trial. Diabetologia 2008 published on-line ahead of print: DOI 10.107/s00125-008-1093-x.
Khan AA, Sandor GKB, Dore E, Morrison AD, Alsahli M, Amin F, Peters E, Hanley DA, Chaudry SR, Dempster DW, Glorieux FH, Neville AJ, Talwar RM, Clokie CM, Al Mardini M, Paul R, Khosla S, Josse RG, Sutherland S, Lam DK, Carmichael RP, Blanas N, Kendler D, Petak S, St-Marie LG, Brown J, Evans AW, Rios L and Compston JE. Canadian Consensus Practice Guidelines for Bisphosphonate Associated Osteonecrosis of the Jaw. J Rheumatol First Release June 1, 2008.
Langsetmo L, Hanley DA, Kreiger N, Jamal SA, Prior JC, Adachi JD, Davison KS, Kovacs C, Anastassiades T, Tenenhouse A, Goltzman D, CaMos Research Group. Geographic variation of bone mineral density and selected risk factors for prediction of incident fracture among Canadians 50 and older. Bone 2008 Oct;43(4):672-8. [Epub 2008 Jul 1].
Berger C, Langsetmo L, Joseph L, Hanley DA, Goltzman D, Tenenhouse A, Josse RG, Davison S, and the CaMos Research Group. Change in Bone Mineral Density (BMD) as a Function of Age in Women and Men and Association with the Use of Antiresorptive Agents. CMAJ 2008;178(13):1660-1668.
Saad F, Adachi JD, Brown JP, Canning LA, Gelmon KA, Josse RG, Pritchard KI. Cancer treatment induced bone loss in breast and prostate cancer. J Clin Oncol 2008 Nov 20;26(33):5465-76.
Cheung AM, Tile L, Lee Y, Tomlinson G, Hawker G, Scher J, Hu H, Vieth R, Thompson L, Jamal S, Josse RG. Vitamin K Supplementation in Postmenopausal Women with Osteopenia: The ECKO trial. PLoS Med 5(10): e196 doi:10.1371/journal.pmed.0050196.
Whitson HE, Sanders L, Pieper CF, Gold DT, Papaioannou A, Richards JB, Adachi JD, Lyles KW, CaMos Research Group. Depressive Symptomatology and Fracture Risk in Community-Dwelling Older Men and Women. Aging Clin Exp Res 2008 Dec;20(6):585‑92.
Jenkins DJA, Kendall CWC, McKeown-Eyssen G, Josse RG, Silverberg J, Booth GL, Vidgen E, Josse AR, Nguyen TH, Corrigan S, Banach MS, Ares S, Mitchell S, Emam A, Augustin LSA, Parker TL, Leiter LA. Effect of a Low–Glycemic Index or a High–Cereal Fiber Diet on Type 2 Diabetes. JAMA 2008 Dec;300(23):2742-2753.
Jenkins DJA, Nguyen TH, Kendall CWC, Faulkner DA, Bashyam B, Kim IJ, Ireland C, Patel D, Vidgen E, Josse, AR, Sesso HD, Burton-Freeman B, Josse RG, Leiter LA, Singer W. The effect of strawberries in a cholesterol‑lowering dietary portfolio. Metabolism 2008, Dec,01;57(12):1636-44.
Papaioannou A, Kennedy CC, Ioannidis G, Sawka A, Hopman WM, Pickard L, Brown JP, Josse RG, Kaiser S, Anastassiades T, Goltzman D, Papadimitropoulos M, Tenenhouse A, Prior JC, Olszynski WP, Adachi JD, for the CaMos Study Group. The Impact of Incident Fractures on Health Related Quality of Life: Five Years of Data from the Canadian Multicentre Osteoporosis Study. Osteoporosis Int. [Epub 2008 Sep 19].
Berger C, Langsetmo L, Joseph L, Hanley DA, Davison KS, Josse RG, Prior JC, Kreiger N, Tenenhousae A, Goltzman D. Association Between Change in Bone Mineral Density (BMD) and Fragility Fracture in Women and Men. J Bone Miner Res 2009 Feb;24:361-370. [Epub 2008 Oct 10].
Langsetmo L, Morin S, Richards JB, Davison KS, Olszynski WP, Prior JC, Josse RG, Goltzman D and the CaMos Research Group. Effectiveness of antiresorptives for the prevention of non-vertebral low-trauma fractures in a population-based cohort of women. Osteoporosis Int 2009 Feb;20(2):283-90. [Epub 2007 Jun 26].
Chen P, Krege JH, Adachi JD, Prior JC, Tenenhouse A, Brown JP, Papadimitropoulos E, Kreiger N, Olszynski WP, Josse RG, Goltzman D. Vertebral Fracture Status and the World Health Organization Risk Factors for Predicting Osteoporotic Fracture Risk. J Bone Min Res 2009 Mar;24(3):495‑502. [Epub 2008 Nov 18]. (doi: 10.1359/jbmr.081103).
Khan AA, Sándor GKB, Dore E, Morrison AD, Alsahli M, Amin F, Peters E, Hanley DA, Chaudry SR, Lentle B, Dempster DW, Glorieux FH, Neville AJ, Talwar RM, Clokie CM, Al Mardini M, Paul T, Khosla S, Josse RG, Sutherland S, Lam DK, Carmichael RP, Blanas N, Kendler D, Petak S, St. Marie LG, Brown J, Evans AW, Rios L, Compston JE. Systematic Review: Bisphosphonate‑Associated Osteonecrosis of the Jaw (ONJ). Endorsed by, Canadian Association of Oral and Maxillofacial Surgeons (CAOMS), Canadian Society of Endocrinology and Metabolism (CSEM), Ontario Society of Oral and Maxillofacial Surgeons (OSOMS), Canadian Academy of Oral & Maxillofacial Pathology and Oral Medicine (CAOMPOM), International Bone & Mineral Society (IBMS). J Rheumatol 2009 Mar;36:3;doi:10.3899/jrheum.080759.
Jamal SA, Goltzman D, Hanley DA, Papaioannou A,Prior JC, Josse RG. Nitrate Use and Changes in Bone Mineral Density in Canadian Men and Women; The Canadian Multicentre Osteoporosis Study. Osteoporosis Int 2009 May 20;5:737‑744. [Epub 2008 Sep 18]. (doi:10.1007/s00198-008-0727-7).
Mithal A, Wahl DA, Bonjour J-P, Burckhardt P, Dawson-Hughes B, Eisman A, El‑Hajj Fuleihan G, Josse RG, Lips P, Morales-Torres J, on behalf of the IOF Committee of Scientific Advisors (CSA) Nutrition Working Group. Global Vitamin D status and determinants of hypovitaminosis D. Osteoporosis Int 2009 DOI 10.1007/S00198-009-0954-6. Published online: 19 June 2009.
Kendler DL, Adachi JD, Josse RG, and Slosman DO. Monitoring strontium ranelate therapy in osteoporosis patients. Osteoporosis Int 2009 Jul;20(7):1101‑06, DOI 10.1007/s00198-009-0886-1.
Langsetmo L, Goltzman D, Kovacs CS, Adachi JD, Hanley DA, Kreiger N, Josse RG, Papaioannou A, Olszynski WP, Jamal SA. Repeat Low‑trauma Fractures Occur Frequently Among Men and Women Who Have Osteopenic Bone Density. JBMR Volume 24, Number 9, 2009. Published online on March 30, 2009, doi: 10.1359/JBMR.090319.
Ioannidis G, Papaioannou A, Hopman WM, Akhtar-Danesh N, Anastassiades T, Pickard L, Kennedy C, Prior JC, Olszynski WP, Davison KS, Goltzman D, Thabane L, Gafni A, Papadimitropoulos EA, Brown JP, Josse RG, Hanley DA, Adachi JD, and the CaMos Research Group. Relation between fractures and mortality: results from the Canadian Osteoporosis Multicentre Study. CMAJ 2009. DOI:10.1503/cmaj.081720.
Brown JP, Albert C, Nassar BA, Adachi JD, Cole D, Davison KS, Dooley KC, Don‑Wauchope A, Douville P, Hanley DA, Jamal SA, Josse RG, Kaiser S, Krahn J, Krause R, Kremer R, Lepage R, Letendre E, Morin S, Ooi DS, Papaioannou A, Ste-Marie LG. Bone turnover markers in the management of postmenopausal osteoporosis. Clin Biochem 2009. DOI.10.1016/jclinbiochem.2009.04.001.
Schnell O, Chan J, Josse RG. Therapeutic Experience with Acarbose in the Treatment of Type 2 Diabetes. Diabetes, Stoffwechsel und Herz 2009;18:409‑415.
Cheng AYY, Josse RG. Rosiglitazone maleate + Metformin hydrochloride Extend: Review of an Emerging Compound. Expert Opinion On Investigational Drugs. September 2009 18;9:1365-1373. DOI: 10.1517/13543780903143753
Hopman WM, Berger C, Joseph L, Towheed T, Prior JC, Anastassiades T, Poliquin S, Zhou W, Adachi JD, Hanley DA, Papadimitropoulos EA, Tenenhouse A and the CaMos Research Group. Health-Related Quality of Life in Canadian Adolescents and Young AdultsL Normative Data using the SF-36. CJPH 2009 Nov-Dec;100(6):449-52.
Jovanovski E, Jenkins A, Dias A, Peeva V, Sievenpiper J, Arnason JT, Rahelic D, Josse RG and Vuksan V. Effects of Korean Red Ginseng (Panax ginseng C.A. Mayer) and Its Isolated Ginsenosides and Polysaccharides on Arterial Stiffness in Healthy Individuals. Am J Hypertens 2010. doi:10.1038/ajh.2010.5.
Sawka AM, Ismaila N, Cranney A, Thabane L, Kastner M, Gafni A, Woodhouse LJ, Crilly R, Cheung A, Adachi JD, Josse RG, Papaioannou A. A Scoping Review of Strategies for the Prevention of Hip Fracture in Elderly Nursing Home Residents. PLOS Medicine March 2010. 5;I3:e9515.
Langsetmo L, Poliquin S, Hanley DA, Prior JC, Barr S, Anastassiades T, Towheed T, Goltzman D, Kreiger N, CaMos Research Group. Dietary Patterns in Canadian men and women ages 25 and over: relationship to demographics, body mass index, and bone mineral density. BMC Musculoskeletal Disorders 2010, 11:20.