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Richard P. Bazinet, Ph.D.
| Assistant Professor Department of Nutritional Sciences Faculty of Medicine Tel: (416) 946-8276 |
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Research
The overall goal of my research program is to identify the mechanisms that regulate brain lipid metabolism (signaling) and to identify the role of brain lipid metabolism in the pathogenesis of neurodegenerative diseases and neuropsychiatric disorders. We are currently taking a kinetic and biochemical approach to studying the mechanisms by which dietary polyunsaturated fatty acids regulate the metabolism of arachidonic and docosahexaenoic acids within brain phospholipids. We are also investigating the role of dietary polyunsaturated fatty acids in rodent models of neuroinflammation and Alzheimer's disease.
Selected Publications
Song BJ, Elbert A, Rahman T, Orr SK, Chen CT, Febbraio M, Bazinet RP. Genetic ablation of CD36 does not alter mouse brain polyunsaturated fatty acid concentrations. Lipids. 2010 Apr;45(4):291-9.
Orr SK, Tong JYM, Kang JX, Ma DWL, Bazinet RP. The fat-1 mouse has brain docosahexaenoic acid levels achievable through fish oil feeding. Neurochem Res.2010 May;35(5):811-9.
Boudrault C, Bazinet RP, Kang JX, Ma DW. Cyclooxygenase-2 and n-6 PUFA are lower and DHA is higher in the cortex of fat-1 mice. Neurochem Int. 2010 Mar;56(4):585-9.
Duncan RE, Bazinet RP. Brain arachidonic acid uptake and turnover: Implications for signaling and the regulation of mood. Curr Opin Clin Nutr Metab Care.2010 Mar;13(2):130-8.
Lee HJ, Bazinet RP, Rapoport SI, Bhattacharjee AK. Brain Arachidonic Acid Cascade Enzymes are Upregulated in a Rat Model of Unilateral Parkinson Disease. Neurochem Res 2010 Apr;35(4):613-9.
Bazinet RP. Aspirin, arachidonic acid and the regulation of mood. Prostaglandins Leukot Essent Fatty Acids. 2010 Jan;82(1):7-8.
Rahman T, Taha AY, Song BJ, Orr SK, Liu Z, Chen CT, Bazinet RP. The very low density lipoprotein receptor is not necessary for maintaining brain polyunsaturated fatty acid concentrations. Prostaglandins Leukot Essent Fatty Acids. 2010 February - March;82(2-3):141-145.
Grigoriadis S, Barrett J, Pittini R, Herer E, Zaltx A, Bazinet RP, Bradley L, Kennedy S, Steiner M, Levitt A. Omega 3 Supplements in Pregnancy: Are We Too Late to Identify the Possible Benefits? J Obstet Gynaecol Can 2010;32(3):209-216.
Crawford MA, Bazinet RP, Sinclair AJ. Fat Intake and CNS Functioning: Ageing and Disease. Ann Nutr Metab. 2009 Oct;37(Pt 5):1104-9.
Bazinet RP. Is the brain arachidonic acid cascade a common target of drugs used to manage bipolar disorder? Biochem Soc Trans. 2009;55(1-3):202-28.
Green JT, Liu Z, Bazinet RP. Brain phospholipid arachidonic acid half lives are not altered following 15 weeks of n-3 polyunsaturated fatty acid adequate or deprived diet. J Lipid Res. 2010 Mar;51(3):535-43.
Ouellet M, Emond V, Chen CT, Julien C, Bourasset F, Oddo S, LaFerla F, Bazinet RP, Calon F. Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood-brain barrier: an in situ cerebral perfusion study. Neurochem Int. 2009 Dec;55(7):476-82.
Sievenpiper JL, Kendall CW, Esfahani A, Wong JM, Carleton AJ, Jiang HY, Bazinet RP, Vidgen E, Jenkins DJ. Effect of non-oil seed pulses on glycemic control: A meta-analysis of randomized controlled experimental trials in people with and without diabetes. Diabetologia. 2009 Aug;52(8):1479-95.
Chen TZ, Liu Z, Ouellet M, Calon F, Bazinet RP. Rapid b-oxidation of eicosapentaenoic acid in mouse brain: An in situ study. Prostaglandins Leukot Essent Fatty Acids. 2009 Feb-Mar;80(2-3):157-63.
Chen TZ, Green JT, Orr SK, Bazinet RP. Regulation of brain polyunsaturated fatty acid uptake and turnover. Prostaglandins Leukot Essent Fatty Acids. 2008 Sep-Nov;79(3-5):85-91.
Milligan LA, Bazinet RP. Evolutionary modifications on human milk composition: evidence from long-chain polyunsaturated fatty acid composition of anthropoid milks. J Hum Evol. 2008 Dec;55(6):1086-95.
Taha AY, Chen CT, Liu Z, Kim JH, Mount HT, Bazinet RP. Brainstem concentrations of cholesterol are not influenced by genetic ablation of the low-density lipoprotein receptor. Neurochem Res. 2009 Feb;34(2):311-5.
Orr SK, Bazinet RP. The emerging role of docosahexaenoic acid in neuroinflammation. Curr Opin Investig Drugs. 2008 Jul;9(7):735-43.
Boudrault C, Bazinet RP, Ma DWL. Experimental Models and Mechanisms Underlying the Protective Effects of n-3 Polyunsaturated Fatty Acids in Alzheimer's Disease. J Nutr Biochem. 2009 Jan;20(1):1-10.
Bhattacharjee AK, Chang L, Chen M, White L, Bell JM, Bazinet RP and Rapoport SI. Chronic D-amphetamine depresses an imaging marker of arachidonic acid metabolism in rat brain. Int J Neuropsychopharmacol. 2008 Jun 23:1-13.
Rao JS, Lee HJ, Rapoport SI, Bazinet RP. Mode of action of mood stabilizers: Is the arachidonic acid cascade a common target? 2008 Mol Psychiatry. Jun;13(6):585-96.
Green JT, Orr SK, Bazinet RP. The emerging role of group VI calcium-independent phospholipase A2 in releasing docosahexaenoic acid from brain phospholipids. J Lipid Res. 2008 May;49(5):939-44.
Bhattacharjee AK, Chang L, White L, Bazinet RP, Rapoport SI. Imaging apomorphine stimulation of brain arachidonic acid signalling via D2-like receptors in unanesthetized rats. Psychopharmacology (Berl). 2008 May;197(4):557-66.
Lee HJ, Rao JS, Chang L, Rapoport SI, Bazinet RP. Chronic N-methyl-D-aspartate administration increases the turnover of arachidonic acid within brain phospholipids of the unanesthetized rat. J Lipid Res. 2008 Jan;49(1):162-8.
Chen CT, Ma DW, Kim JH, Mount HT, Bazinet RP. The low-density lipoprotein receptor is not necessary for maintaining mouse brain polyunsaturated fatty acid concentrations. J Lipid Res. 2008 Jan;49(1):147-52.
Lee HJ, Ertley RN, Rapoport SI, Bazinet RP, Rao JS. Chronic administration of lamotrigine downregulates COX-2 mRNA and protein in rat frontal cortex. Neurochem Res. 2008 May;33(5):861-6.
Milligan LA, Rapoport SI, Cranfield MR, Dittus W, Glander KE, Oftedal OT, Power ML, Whittier CA, Bazinet RP. Fatty acid composition of wild anthropoid primate milks. Comp Biochem Physiol B Biochem Mol Biol. 2 2008 Jan;149(1):74-82.