Michael C. Archer, M.A., Ph.D. , D.Sc.

Faculty of Medicine University of Toronto FitzGerald Building, Room 146 150 College Street Toronto ON M5S 3E2 CANADA Tel: (416) 978 8195 Fax: (416) 978 5882 E-mail: m.archer@utoronto.ca

Research

One objective of my research program is to identify molecular targets of dietary factors involved in breast and colon cancer development. Current research focuses on HMG-CoA reductase and the mevalonate pathway, cyclooxygenase-2, fatty acid synthase, and insulin, IGF-I, and other obesity-related factors. A second objective is to understand the genetic basis for the differences in susceptibility of rat strains to breast and liver cancer induction.

Selected Publications

• Ealey, K.N., Xuan, W., Lu, S. and Archer, M.C. Colon carcinogenesis in liver-specific IGF-I-deficient (LID) mice. Int. J. Cancer, 122, 472-476, 2008.

• Ealey, K.N., Lu, S., Lau, D.S.Y. and Archer, M.C. Reduced susceptibility of muscle-specific insulin receptor knockout (MIRKO) mice to colon carcinogenesis. Am. J. Physiol. 294, G679-G686, 2008.

• Duncan, R.E., and Archer, M.C. Farnesol decreases serum triglycerides in rats: Identification of mechanisms including up-regulation of PPARα and down-regulation of fatty acid synthase in hepatocytes. Lipids, 43, 619-627, 2008.

• Ealey, K.N, Lu, S., and Archer, M.C. Development of aberrant crypt foci in the colons of ob/ob and db/db mice: evidence that leptin in not a promoter. Molecular Carcinogenesis, 47, 667-677, 2008.

• Corpet, D.E., Tache, S., Archer, M.C. and Bruce, W.R. Dehydroalanine and lysinoalanine in thermolyzed casein do not promote colon cancer in the rat. Food Chem. Toxicol., 46, 3037-3042, 2008.

• Ealey, K.N., Kaludjerovic, J., Archer, M.C. and Ward, W.E. Adiponectin is a negative regulator of bone mineral and bone strength in growing mice. Exp. Biol. Med. 233, 1546-1543, 2008.

• Xuan, W., Li, Y-J., Ben-David, Y. and Archer, M.C. IL-24 induces expression of β4 integrin and suppresses anchorage-independent growth of rat mammary tumor cells. Mol. Cancer Res., 7, 433-442, 2009.

• Lau, D. S. Y. and Archer, M.C. Fatty acid synthase is over-expressed in large aberrant crypt foci in rats treated with azoxymethane. Int. J. Cancer, 124, 2750-2753, 2009.

• Ealey, K.N. and Archer, M.C. Elevated circulating adiponectin in adiponectin transgenic mice is not associated with reduced susceptibility to colon carcinogenesis. Int. J. Cancer, 124, 2226-2230, 2009.

• Lau, D.S.Y. and Archer, M.C. The 10t,12c isomer of conjugated linoleic acid inhibits fatty acid synthase expression and enzyme activity in human breast, colon and prostate cancer cells. Nutrition and Cancer, 62, 1-6, 2010.

• Lu, S. and Archer, M.C. Sp1 coordinately regulates de novo lipogenesis and proliferation in cancer cells. Int. J. Cancer, 126, 416-425, 2010.

• McNamara, E. and Archer, M.C. Ezetimibe reverses the inhibitory effects of dietary cholesterol on mammary tumorigenesis in rats. Int. J. Cancer, 127, 791-795, 2010.

• Giovannucci, E., Harlan, D.M., Archer, M.C., Bergenstal, R.M., Habel, L.A., Pollack, M., Regensteiner, J.G., and Yee, D. Diabetes and cancer: A consensus report. Diabetes Care, 33, 1-12, 2010, and CA Cancer J. Clin. 60, 207-221, 2010.