Faculty of Medicine
University of Toronto
FitzGerald Building, Room 146
150 College Street
Toronto ON M5S 3E2 CANADA
Tel: (416) 978 8195
Fax: (416) 978 5882
E-mail: m.archer@utoronto.ca |
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One objective of my research program is to identify molecular targets of dietary factors involved in breast and colon cancer development. Current research focuses on HMG-CoA reductase and the mevalonate pathway, cyclooxygenase-2, fatty acid synthase, and insulin, IGF-I, and other obesity-related factors. A second objective is to understand the genetic basis for the differences in susceptibility of rat strains to breast and liver cancer induction.
- Ealey, K.N., Lu, S. and Archer, M.C. Development of aberrant crypt foci in the colons of ob/ob and db/db mice: Evidence that leptin is not a promoter. Mol. Carcinog., 2008 Jan. 31; [Epub ahead of print].
- Ealey, K.N., Lu, S., Lau, D.S. and Archer, M.C. Reduced susceptibility of muscle-specific insulin receptor knockout (MIRKO) mice to colon carcinogenesis. Am. J. Physiol. Gastrointest Liver Physiol., 2008 Jan. 3; [Epub ahead of print].
- Ealey, K.N., Xuan, W., Lu, S. and Archer, M.C. Colon carcinogenesis in liver-specific IGF-I-deficient (LID) mice. Int. J. Cancer, 122, 472-476, 2008.
- Lu, S., and Archer, M.C. Celecoxib reduces fat accumulation in rats by decreasing fatty acid synthase expression via down-regulation of c-Jun amino-terminal kinase1 (JNK1). Exp. Biol. Med. 232, 643-653, 2007.
- Duncan, R.E., and Archer, M.C. Farnesol induces thyroid hormone receptor (THR) ?1 but inhibits THR-mediated signaling in MCF-7 human breast cancer cells. Biochem. Biophys. Res. Commun., 343, 239-243, 2006.
- Lu, S., and Archer, M.C. Fatty acid synthase is a potential molecular target for the prevention of breast cancer. Carcinogenesis, 26, 153-157, 2005.
- Duncan, R.E., and Archer, M.C. Review: Dietary factors and the regulation of HMG-CoA reductase: implications for breast cancer development. Mol. Nutr. Food Res., 49, 93-100, 2005.
- Lu, S., Yu, G., Zhu, Y., and Archer M.C. Cyclooxygenase-2 over-expression in MCF-10F human breast epithelial cells inhibits proliferation, apoptosis and differentiation, and causes partial transformation. Int. J. Cancer, 116, 847-852, 2005.
- Duncan, R.E., El-Sohemy, A., and Archer, M.C. Statins and cancer development. Cancer Epidemiol. Biomarkers. Prev. 14, 1897-1898, 2005.
