Johane P. Allard M.D., F.R.C.P.

Professor Departments of Medicine (GI Division) and Nutritional Sciences Toronto General Hospital 585 University Avenue 9N-973 Toronto, ON M5G 2C4 Tel: 416 340 5159 Fax: 416 348 0065 E-mail: johane.allard@utoronto.ca

Research

Currently, we are mainly conducting patient based clinical research. Our focus is on the assessment of diet and lifestyle (obesity, physical activity), and on the measurement of oxidative stress, antioxidants and fatty acid composition in different tissues. We investigate the influence of these factors on metabolic abnormalities and hepatic steatosis in patients with Non-alcoholic Fatty Liver disease (NAFLD), HIV, or Hepatitis C (HCV). Another study includes liver-transplant and lung-transplant patients. In the near future we are planning to include the micro array technique to assess gene expression related to fatty acid metabolism in patients with liver disease.

More information on our clinical trials can be found at www.clinicaltrials.gov

Selected Publications

• Aghdassi E, Arendt B, Salit IE, Allard JP. Estimation of body fat mass using dual-energy x-ray absorptiometry, bioelectric impedance analysis, and anthropometry in HIV-positive male subjects receiving highly active antiretroviral therapy. JPEN J Parenter Enteral Nutr. 2007 Mar-Apr;31(2):135-41.
• Allard J. Should nutritional status be routinely assessed and corrected before bariatric surgery? Nat Clin Pract Gastroenterol Hepatol. 2007 Mar;4(3):130-1. E
• Liu BA, McGeer A, McArthur MA, Simor AE, Aghdassi E, Davis L, Allard JP. Effect of multivitamin and mineral supplementation on episodes of infection in nursing home residents: a randomized, placebo-controlled study. J Am Geriatr Soc. 2007 Jan;55(1):35-42. Erratum in: J Am Geriatr Soc. 2007 Mar;55(3):478.
• Raman M, Aghdassi E, Baun M, Yeung M, Fairholm L, Saqui O, Allard JP. Metabolic bone disease in patients receiving home parenteral nutrition: a Canadian study and review. JPEN J Parenter Enteral Nutr. 2006 Nov-Dec;30(6):492-6.
• Raman M, Allard J. Non alcoholic fatty liver disease: a clinical approach and review. Can J Gastroenterol. 2006 May;20(5):345-9.
• Aghdassi E, Salit IE, Fung L, Sreetharan L, Walmsley S, Allard JP. Is chromium an important element in HIV-positive patients with metabolic abnormalities? An hypothesis generating pilot study. J Am Coll Nutr. 2006 Feb;25(1):56-63.
• Chang A, Enns R, Saqui O, Chatur N, Whittaker S, Allard JP. Line sepsis in home parenteral nutrition patients: are there socioeconomic risk factors? A Canadian study. JPEN J Parenter Enteral Nutr. 2005 Nov-Dec;29(6):408-12.
• Fairholm L, Saqui O, Baun M, Allard J. R Influence of multivitamin regimen on urinary oxalate in home parenteral nutrition patients. Nutr Clin Pract. 2003 Oct;18(5):366-9.
• Arcand JA, Brazel S, Joliffe C, Choleva M, Berkoff F, Allard JP, Newton GE. Education by a dietitian in patients with heart failure results in improved adherence with a sodium-restricted diet: a randomized trial. Am Heart J. 2005 Oct;150(4):716.
• Carrier JC, Aghdassi E, Jeejeebhoy K, Allard JP. Exacerbation of dextran sulfate sodium-induced colitis by dietary iron supplementation: role of NF-kappaB. Int J Colorectal Dis. 2006 May;21(4):381-7. Epub 2005 Aug 23.