Recent Publications
Vargas-Perez, H., Ting-A-Kee, R., and van der Kooy, D., Different neural systems mediate morphine reward and its spontaneous withdrawal aversion. European Journal of Neuroscience. (2009). 29:2029-34. :... download in .pdf ...:
Akamatsu, W., Cooney, A.J., and van der Kooy, D. Suppression of Oct4 by germ cell nuclear factor promotes the development of the early neural stem cell lineage. Journal of Neuroscience. (2009). 29:2113-24. :... download in .pdf ...:
Ting-A-Kee, R., Dockstader, C.L., Heinmiller, A., Grieder, T., and van der Kooy, D. . GABA(A) receptors mediate the opposing roles of dopamine and the tegmental pedunculopontine nucleus in the motivational effects of ethanol. European Journal of Neuroscience. (2009). 29:1235-44. :... download in .pdf ...:
Clarke L, van der Kooy D. Low Oxygen Enhances Primitive and Definitive Neural Stem Cell Colony Formation By Inhibiting Distinct Cell Death Pathways. Stem Cells. (2009). PMID: 19544448. :... download in .pdf ...:
Vargas-Perez H, Ting-A-Kee RA, Heinmiller A, Sturgess JE, van der Kooy D. A test of the opponent-process theory of motivation using lesions that selectively block morphine reward. Eur J Neurosci. 2007 Jun;25(12):3713-8. :... download in .pdf ...:
Liu, H., Xu, S., Wang, Y., Mazerolle, C., Thurig, S., Coles, B., Ren, J-C., Taketo, M., van der Kooy, D., and Wallace, V. Cilliary margin transdifferentiation from neural retina is controlled by canonical Wnt signalling. (2007) July; 308: 54-67. :... download in .pdf ...:
Karpowicz, P., Inoue, T., Runciman, S., DeVeale, B., Seaberg, R., Gertsenstein, M., Byers, L., Yamanaka, Y., Tondat, S., Slevin, J., Hitoshi, S., Rossant, J., and van der Kooy, D. Adhesion Is Prerequisite, But Alone Insufficient, to Elicit Stem Cell Pluripotency. Journal of Neuroscience. (2007) May; (27)20: 5437-5447. :... download in .pdf ...:
Xu, S., Sunderland, M., Coles, B., Kam, A., Holowacz, T., Ashery-Padan, R., Marquardt, T., McInnes, R., and van der Kooy, D. The proliferation and expansion of retinal stem cells require functional PAX6. Developmental Biology. (2007) Apr; 304(2): 713-21. :... download in .pdf ...:
Batista, C.M.C., Kippin, T.E., Akamatsu, W., Willaime-Morawek, S., and van der Kooy, D. A progressive and non cell autonomous increase in striatal neural stem cells in the Huntington's disease R6/2 Mouse. Journal of Neuroscience (2006) Oct 11;26(41):10452-60. :... download in .pdf ...:
Willaime-Morawek, S., Seaberg, R., Batista, C., Labbe, E., Attisano, L., Gorski, J., Jones, K., Kam, A., Morshead, C., and van der Kooy, D. Embryonic cortical neural stem cells migrate ventrally and persist as postnatal striatal stem cells. Journal of Cell Biology. (2006) Oct 9;175(1):159-68. :... download in .pdf ...:
Wada, T., Haigh, J., Ema, M., Hitoshi, S., Chaddah, R., Rossant, J., Nagy, A., and van der Kooy, D. VEFG directly inhibits primitive neural stem cell survival but promotes definitive neural stem cell survival. Journal of Neuroscience. (2006) Jun 21;26(25):6803-12. :... download in .pdf ...:
Coles, B.L.K., Horsford, D.J., McInnes, R.R. and van der Kooy, D. Loss of retinal progenitor cells leads to an increase in the retinal stem cell population in vivo. European Journal of Neuroscience (2006) Jan;23(1):75-82. :... download in .pdf ...:
Alexson, T.O., Hitoshi, S., Coles, B.L., Bernstein, A., and van der Kooy, D. Notch signaling is required to maintain all neural stem cell populations – irrespective of spatial or temporal niche. Developmental Neuroscience (2006) 28(1-2):34-48.
Smukler SR, Runciman SB, Xu S, van der Kooy D. Embryonic stem cells assume a primitive neural stem cell fate in the absence of extrinsic influences. Journal of Cell Biology 172 (2006) 79-90. :... download in .pdf ...:
Karpowicz, P., Cohen, C.B., and van der Kooy, D. Developing Human-Nonhuman Chimeras in Human Stem Cell Research: Ethical Issues and Boundaries. Kennedy Institute of Ethics Journal 15 (2005) 107-134.
Kippin, T.E., Kapur, S., and van der Kooy, D. Dopamine Specifically Inhibits Forebrain Neural Stem Cell Proliferation, Suggesting a Novel Effect of Antipsychotic Drugs. Journal of Neuroscience 25 (2005) 5815-5823. :... download in .pdf ...:
Seaberg, R.M., Smukler, S.R., and van der Kooy, D. Intrinsic differences distinguish transiently neurogenic progenitors from neural stem cells in the early postnatal brain. Developmental Biology 278 (2005) 71-85. :... download in .pdf ...:
Karpowicz P, Morshead C, Kam A, Jervis E, Ramunas J, Cheng V, van der Kooy D. Support for the immortal strand hypothesis: neural stem cells partition DNA asymmetrically in vitro. Journal of Cell Biology 170 (2005) 721-32. :...download in .pdf ...:
Kippin TE, Martens DJ, van der Kooy D. p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity. Genes and Development 19 (2005) 756-67. :... download in .pdf ...:
Atkinson-Leadbeater K, Nuttley WM, van der Kooy D. A genetic dissociation of learning and recall in Caenorhabditis elegans. Behavioural Neuroscience 118 (2004) 1206-13.
Zhang W, Morris QD, Chang R, Shai O, Bakowski MA, Mitsakakis N, Mohammad N, Robinson MD, Zirngibl R, Somogyi E, Laurin N, Eftekharpour E, Sat E, Grigull J, Pan Q, Peng WT, Krogan N, Greenblatt J, Fehlings M, van der Kooy D, Aubin J, Bruneau BG, Rossant J, Blencowe BJ, Frey BJ, Hughes TR. The functional landscape of mouse gene expression.
J Biol. 2004;3(5):21. :... download in .pdf ...:
Coles BL, Angenieux B, Inoue T, Del Rio-Tsonis K, Spence JR, McInnes RR, Arsenijevic Y, van der Kooy D. Facile isolation and the characterization of human retinal stem cells. Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15772-7. :... download in .pdf ...:
Laviolette SR, van der Kooy D. GABAA receptors signal bidirectional reward transmission from the ventral tegmental area to the tegmental pedunculopontine nucleus as a function of opiate state. Eur J Neurosci. 2004 Oct;20(8):2179-87. :...download in .pdf ...:
Seaberg RM, Smukler SR, Kieffer TJ, Enikolopov G, Asghar Z, Wheeler MB, Korbutt G, van der Kooy D.Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages. Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages. Nat Biotechnol. 2004 Sep;22(9):1115-24. :...download in .pdf ...:
Hitoshi S, Seaberg RM, Koscik C, Alexson T, Kusunoki S, Kanazawa I, Tsuji S, van der Kooy D.Primitive neural stem cells from the mammalian epiblast differentiate to definitive neural stem cells under the control of Notch signaling. Genes Dev. 2004 Aug 1;18(15):1806-11. :... download in .pdf ...:
Law E, Nuttley WM, van der Kooy D. Contextual taste cues modulate olfactory learning in C. elegans by an occasion-setting mechanism. Curr Biol. 2004 Jul 27;14(14):1303-8. :...download in .pdf ...:
Karpowicz P, Cohen CB, van der Kooy D. It is ethical to transplant human stem cells into nonhuman embryos. Nat Med. 2004 Apr;10(4):331-5. :...download in .pdf ...:
Morshead CM, van der Kooy D. Disguising adult neural stem cells. Curr Opin Neurobiol. 2004 Feb;14(1):125-31. :...download in .pdf ...:
Sanyal S, Wintle RF, Kindt KS, Nuttley WM, Arvan R, Fitzmaurice P, Bigras E, Merz DC, Hebert TE, van der Kooy D, Schafer WR, Culotti JG, Van Tol HH. Dopamine modulates the plasticity of mechanosensory responses in Caenorhabditis elegans. EMBO J. 2004 Jan 28;23(2):473-82. :...download in .pdf ...:
Laviolette SR, Gallegos RA, Henriksen SJ, van der Kooy D. Opiate state controls bi-directional reward signaling via GABAA receptors in the ventral tegmental area. Nat Neurosci. 2004 Feb;7(2):160-9. :...download in .pdf ...:
Laviolette SR, van der Kooy D. The neurobiology of nicotine addiction: bridging the gap from molecules to behaviour. Nat Rev Neurosci. 2004 Jan;5(1):55-65. :...download in .pdf ...:
Kippin TE, van der Kooy D. Excitotoxic lesions of the tegmental pedunculopontine nucleus impair copulation in naive male rats and block the rewarding effects of copulation in experienced male rats. Eur J Neurosci. 2003 Nov;18(9):2581-91. :...download in .pdf ...:
Morshead CM, Garcia AD, Sofroniew MV, van der Kooy D. The ablation of glial fibrillary acidic protein-positive cells from the adult central nervous system results in the loss of forebrain neural stem cells but not retinal stem cells. Eur J Neurosci. 2003 Jul;18(1):76-84. :...download in .pdf ...:
Nuttley WM, Atkinson-Leadbeater KP, Van Der Kooy D. Serotonin mediates food-odor associative learning in the nematode Caenorhabditiselegans. Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12449-54. :...download in .pdf ...:
V. Tropepe, S. Hitoshi, C. Sirard, T. Mak, J. Rossant, van der Kooy D. Direct neural fate specification from embryonic stem cells: a primitive mammalian neural stem cell stage acquired through a default mechanism. Neuron. 2001 Apr;30(1): 65-78. :...download in .pdf ...:
Tropepe V, Coles BL, Chiasson BJ, Horsford DJ, Elia AJ, McInnes RR, van der Kooy D. Retinal stem cells in the adult mammalian eye. Science. 2000 Mar 17 287: 2032-6. :...download in .pdf ...:
van der Kooy & Weiss, S. Why Stem Cells? Science. 2000 Feb 25; 287: 1439-41. :...download in .pdf ...:
**photo credit: Sandrine Willaime-Morawek**