Recent Publications
2010
Sturgess, J.E., Ting-A-Kee, R.A., Podbielski, D., Sellings, L.H., Chen, J.F., van der Kooy, D. (2010). Adenosine A and A receptors are not upstream of caffeine's dopamine D receptor-dependent aversive effects and dopamine-independent rewarding effects. Eur J Neurosci. 32(1):143-54. :... download in .pdf ...:
Lin CH, Tomioka M, Pereira S, Sellings L, Iino Y, van der Kooy D. (2010). Insulin signaling plays a dual role in Caenorhabditis elegans memory acquisition and memory retrieval. J Neurosci. 30(23):8001-11. :... download in .pdf ...:
Hoffmann, M.C., Sellings, L.H., van der Kooy, D. (2010). A diacetyl-induced quiescence in young Caenorhabditis elegans. Behav Brain Res. [Epub ahead of print] :... download in .pdf ...:
Ballios, B.G., Cooke, M.J., van der Kooy, D., and Shoichet, M.S. A hydrogel-based stem cell delivery system to treat retinal degenerative diseases. Biomaterials. 31 (2010) 2555-2564. :... download in .pdf ...:
Grieder, T.E., Sellings, L.H., Vargas-Perez, H., Ting-A-Kee, R., Siu, E.C., Tyndale, R.F., van der Kooy D. (2010). Dopaminergic signaling mediates the motivational response underlying the opponent process to chronic but not acute nicotine. Neuropsychopharmacology. 35(4):943-54. :... download in .pdf ...:
Inoue, T., Coles, B.L., Dorval, K., Bremner, R., Bessho, Y., Kageyama, R., Hino, S., Matsuoka, M., Craft, C.M., McLnnes, R.R., Temblay, F., Prusky, G.T., van der Kooy, D. (2010). Maximizing functional photoreceptor differentiation from adult human retinal stem cells. Stem Cells. [Epub ahead of print] :... download in .pdf ...:
2009
McKay, R.D., van der Kooy, D., Zwaka, T.P., Lin, H. (2009). Stem cells in 2009. Cell Stem Cell. 5(5):483-9. :... download in .pdf ...:
Clarke, L., van der Kooy, D. (2009). Low oxygen enhances primitive and definitive neural stem cell colony formation by inhibiting distinct cell death pathways. Stem Cells. 27(8):1879-86. :... download in .pdf ...:
Clarke, L., van der Kooy, D. (2009). A safer stem cell: inducing pluripotency. Nature Medicine. 15(9):1001-2. :... download in .pdf ...:
Calarco, J.A., Superina, S., O'Hanlon, D., Gabut, M., Raj, B., Pan, Q., Skalska, U., Clarke, L., Gelinas, D., van der Kooy, D., Zhen, M., Ciruna, B., Blencowe, B.J. (2009). Regulation of vertebrate nervous system alternative splicing and development by an SR-related protein. Cell. 138(5):898-910. :... download in .pdf ...:
Vargas-Perez, H., Ting-A-Kee, R., and van der Kooy, D. (2009). Different neural systems mediate morphine reward and its spontaneous withdrawal aversion. European Journal of Neuroscience. 29:2029-34. :... download in .pdf ...:
Akamatsu, W., DeVeale, B., Okano, H., Cooney, A.J., and van der Kooy, D. (2009). Suppression of Oct4 by germ cell nuclear factor restricts pluripotency and promotes neural stem cell development in the early neural lineage. Journal of Neuroscience. 29:2113-24. :... download in .pdf ...:
Vargas-Perez, H., Ting-A-Kee, R., Walton, C.H., Hansen, D.M., Razavi, R., Laura Clarke, L., Bufalino, M., Allison, D.W., Steffensen, S.C., van der Kooy, D. (2009). Ventral tegmental area BDNF induces an opiate-dependent–like reward state in naïve rats. Science. 324(5935):1732-4 :... download in .pdf ...:
Karpowicz, P., Pellikka, M., Chea, E., Godt, D., Tepass, U., van der Kooy, D. (2009). The germline stem cells of Drosophila melanogaster partition DNA non-randomly. European Journal Cell Biology. 88(7):397-408. :...download in .pdf...:
Ting-A-Kee, R., Dockstader, C., Heinmiller, A., Grieder, T., van der Kooy, D. (2009). GABA(A) receptors mediate the opposing roles of dopamine and the tegmental pedunculopontine nucleus in the motivational effects of ethanol. European Journal Neuroscience. 29(6):1235-44. :...download in .pdf...:
Karpowicz, P., Willaime-Morawek, S., Balenci, L., DeVeale, B., Inoue, T., van der Kooy, D. (2009). E-Cadherin regulates neural stem cell self-renewal.
Journal of Neuroscience. 29: 3885-3896. :...download in .pdf...:
Heinmiller, A., Ting-A-Kee, R., Vargas-Perez, H., Yeh, A., van deer Kooy, D. (2009). Tegmental pedunculopontine glutamate and Gaba-B synapses mediate morphine reward. Behavioural Neuroscience. 123(1):145-55. :...download in .pdf...:
2008
Deguchi, K., Clewing, J.M., Elizondo, L.I., Hirano, R., Huang, C., Choi, K., Sloan, E.A., Lu&diecke, T., Marwedel, K.M. , Powell, R.D. Jr, Santa Cruz, K., Willaime-Morawek, S., Inoue, K., Lou, S., Northrop, J.L., Kanemura, Y., van der Kooy, D., Okano, H., Armstrong, D.L. and Boerkoel, C.F. (2008). Neurologic phenotype of schimkeImmuno – osseous dysplasia and neurodevelopmental expression of SMARCAL1. Journal of Neuropathology and Experimental Neurology. 67 (6): 565-577. :...download in .pdf...:
Coles-Takabe, B.L.K., Purpura, K.A., Brain, I., Karpowicz, P., Zandstra, P.W., Morshead, C.M., van der Kooy, D. (2008). Don't Look: Growing clonal versus non-clonal neural stem cell colonies. Stem Cells. 26(11):2938-44. :...download in .pdf...:
Tsui, D., & van der Kooy, D. (2008). Serotonin mediates a learned increase in attraction to high concentrations of benzaldehyde in aged C. elegans. Learning and Memory. 15(11): 844-55. :...download in .pdf...:
Willaime-Morawek, S., van der Kooy, D. (2008). Cortex- and striatum- derived neural stem cells produce distinct progeny in the olfactory bulb and striatum. European Journal of Neuroscience. 27(9):2354-62. :...download in .pdf...:
Babak, T., Deveale, B., Armour, C., Raymond, C., Cleary, M.A., van der Kooy, D., Johnson, J.M., Lim, L.P. (2008). Global survey of genomic imprinting by transcriptome sequencing. Current Biololgy. 18(22):1735-41. :...download in .pdf...:
2007
Fagnani, M., Barash, Y., Ip, J.Y., Misquitta, C., Pan, Q., Saltzman, A.L., Shai, O., Lee, L., Rozenhek, A., Mohammad, N., Willaime-Morawek, S., Babak, T., Zhang, W., Hughes, T.R., van der Kooy, D., Frey, B.J., Blencowe, B.J. (2007). Functional coordination of alternative splicing in the mammalian central nervous system. Genome Biology. 8:R108 :...download in .pdf...:
Vargas-Perez, H., Ting-A-Kee, R.A., Heinmiller, A., Sturgess, J.E., van der Kooy, D. (2007). A test of the opponent-process theory of motivation using lesions that selectively block morphine reward.
European Journal of Neuroscience. 25(12):3713-8. :...download in.pdf...:
Liu, H., Xu, S., Wang, Y., Mazerolle, C., Thurig, S., Coles, B., Ren, J-C., Taketo, M., van der Kooy, D., and Wallace, V. (2007). Cilliary margin transdifferentiation from neural retina is controlled by canonical Wnt signalling. Developmental Biology. 308: 54-67. :... download in .pdf ...:
Karpowicz, P., Inoue, T., Runciman, S., DeVeale, B., Seaberg, R., Gertsenstein, M., Byers, L., Yamanaka, Y., Tondat, S., Slevin, J., Hitoshi, S., Rossant, J., and van der Kooy, D. (2007). Adhesion is prerequisite, but alone insufficient, to elicit stem cell pluripotency. Journal of Neuroscience. (27)20: 5437-5447. :... download in .pdf ...:
Xu, S., Sunderland, M., Coles, B., Kam, A., Holowacz, T., Ashery-Padan, R., Marquardt, T., McInnes, R., and van der Kooy, D. (2007). The proliferation and expansion of retinal stem cells require functional PAX6. Developmental Biology. 304(2): 713-21. :... download in .pdf ...:
2006
Batista, C.M.C., Kippin, T.E., Akamatsu, W., Willaime-Morawek, S., and van der Kooy, D. (2006). A progressive and non cell autonomous increase in striatal neural stem cells in the Huntington's disease R6/2 Mouse. Journal of Neuroscience. 26(41):10452-60. :... download in .pdf ...:
Willaime-Morawek, S., Seaberg, R., Batista, C., Labbe, E., Attisano, L., Gorski, J., Jones, K., Kam, A., Morshead, C., and van der Kooy, D. (2006). Embryonic cortical neural stem cells migrate ventrally and persist as postnatal striatal stem cells. Journal of Cell Biology. 175(1):159-68. :... download in .pdf ...:
Wada, T., Haigh, J., Ema, M., Hitoshi, S., Chaddah, R., Rossant, J., Nagy, A., and van der Kooy, D. (2006). VEFG directly inhibits primitive neural stem cell survival but promotes definitive neural stem cell survival. Journal of Neuroscience. 26(25):6803-12. :... download in .pdf ...:
Coles, B.L.K., Horsford, D.J., McInnes, R.R. and van der Kooy, D. (2006). Loss of retinal progenitor cells leads to an increase in the retinal stem cell population in vivo. European Journal of Neuroscience. 23(1):75-82. :... download in .pdf ...:
Alexson, T.O., Hitoshi, S., Coles, B.L., Bernstein, A., and van der Kooy, D. (2006) Notch signaling is required to maintain all neural stem cell populations – irrespective of spatial or temporal niche. Developmental Neuroscience. 28(1-2):34-48. :... download in .pdf ...:
Smukler, S.R., Runciman, S.B., Xu, S., van der Kooy, D. (2006). Embryonic stem cells assume a primitive neural stem cell fate in the absence of extrinsic influences. Journal of Cell Biology. 172, 79-90. :... download in .pdf ...:
2005
Karpowicz, P., Cohen, C.B., and van der Kooy, D. (2005). Developing human-nonhuman chimeras in human stem cell research: ethical issues and boundaries. Kennedy Institute of Ethics Journal. 15, 107-134. :... download in .pdf ...:
Kippin, T.E., Kapur, S., and van der Kooy, D. (2005). Dopamine specifically inhibits forebrain neural stem cell proliferation, suggesting a novel effect of antipsychotic drugs. Journal of Neuroscience. 25, 5815-5823. :... download in .pdf ...:
Seaberg, R.M., Smukler, S.R., and van der Kooy, D. (2005). Intrinsic differences distinguish transiently neurogenic progenitors from neural stem cells in the early postnatal brain. Developmental Biology. 278, 71-85. :... download in .pdf ...:
Karpowicz, P., Morshead, C., Kam, A., Jervis, E., Ramunas, J., Cheng, V., van der Kooy, D. (2005). Support for the immortal strand hypothesis: neural stem cells partition DNA asymmetrically in vitro. Journal of Cell Biology. 170, 721-32. :...download in .pdf ...:
Kippin, T.E., Martens, D.J., van der Kooy, D. (2005). p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity. Genes and Development. 19, 756-67. :... download in .pdf ...:
2004
Atkinson-Leadbeater, K., Nuttley, W.M., van der Kooy, D. (2004). A genetic dissociation of learning and recall in Caenorhabditis elegans. Behavioural Neuroscience. 118, 1206-13. :... download in .pdf ...:
Zhang, W., Morris, Q.D., Chang, R., Shai, O., Bakowski, M.A., Mitsakakis, N., Mohammad, N., Robinson, M.D., Zirngibl, R., Somogyi, E., Laurin, N., Eftekharpour, E., Sat, E., Grigull, J., Pan, Q., Peng, W.T., Krogan, N., Greenblatt, J., Fehlings, M., van der Kooy, D., Aubin, J., Bruneau, B.G., Rossant, J., Blencowe, B.J., Frey, B.J, Hughes, T.R. (2004). The functional landscape of mouse gene expression. Journal of Biology. 3(5):21. :... download in .pdf ...:
Coles, B.L., Angenieux, B., Inoue, T., Del Rio-Tsonis, K., Spence, J.R., McInnes, R.R., Arsenijevic, Y., van der Kooy, D. (2004). Facile isolation and the characterization of human retinal stem cells. Proceedings of the National Academy of Sciences USA. 101(44):15772-7. :... download in .pdf ...:
Laviolette, S.R., van der Kooy, D. (2004). GABAA receptors signal bidirectional reward transmission from the ventral tegmental area to the tegmental pedunculopontine nucleus as a function of opiate state. European Journal of Neuroscience. 20(8):2179-87. :...download in .pdf ...:
Seaberg, R.M., Smukler, S.R., Kieffer, T.J., Enikolopov, G., Asghar, Z., Wheeler, M.B., Korbutt, G., van der Kooy, D. (2004). Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages. Nature Biotechnology. 22(9):1115-24. :...download in .pdf ...:
Hitoshi, S., Seaberg, R.M., Koscik, C., Alexson, T., Kusunoki, S., Kanazawa, I., Tsuji, S., van der Kooy, D. (2004). Primitive neural stem cells from the mammalian epiblast differentiate to definitive neural stem cells under the control of Notch signaling. Genes Development. 18(15):1806-11. :... download in .pdf ...:
Law, E., Nuttley, W.M., van der Kooy, D. (2004) Contextual taste cues modulate olfactory learning in C. elegans by an occasion-setting mechanism. Current Biology. 14(14):1303-8. :...download in .pdf ...:
Cheng, H.Y., Laviolette, S.R., van der Kooy, D., Penninger, J.M. (2004). DREAM ablation selectively alters THC place aversion and analgesia but leaves intact the motivational and analgesic effects of morphine. European Journal of Neuroscience. 19(11):3033-41. :... download in .pdf ...:
Karpowicz, P., Cohen, C.B., van der Kooy, D. (2004) It is ethical to transplant human stem cells into nonhuman embryos. Nature Medicine. 10(4):331-5. :...download in .pdf ...:
Morshead, C.M., van der Kooy, D. (2004) Disguising adult neural stem cells. Current Opinion in Neurobiology. 14(1):125-31. :...download in .pdf ...:
Sanyal, S., Wintle, R.F., Kindt, K.S., Nuttley, W.M., Arvan, R., Fitzmaurice, P., Bigras, E., Merz, D.C., Hebert, T.E., van der Kooy, D., Schafer, W.R., Culotti, J.G., Van Tol, H.H. (2004). Dopamine modulates the plasticity of mechanosensory responses in Caenorhabditis elegans. EMBO Journal. 23(2):473-82. :...download in .pdf ...:
Laviolette, S.R., Gallegos, R.A., Henriksen, S.J., van der Kooy, D. (2004) Opiate state controls bi-directional reward signaling via GABAA receptors in the ventral tegmental area. Nature Neuroscience. 7(2):160-9. :...download in .pdf ...:
Laviolette, S.R., van der Kooy, D. (2004) The neurobiology of nicotine addiction: bridging the gap from molecules to behaviour. Nature Reviews Neuroscience. 5(1):55-65. :...download in .pdf ...:
2003
Kippin, T.E., van der Kooy, D. (2003). Excitotoxic lesions of the tegmental pedunculopontine nucleus impair copulation in naive male rats and block the rewarding effects of copulation in experienced male rats. European Journal of Neuroscience. 18(9):2581-91. :...download in .pdf ...:
Morshead, C.M., Garcia, A.D., Sofroniew, M.V., van der Kooy, D. (2003). The ablation of glial fibrillary acidic protein-positive cells from the adult central nervous system results in the loss of forebrain neural stem cells but not retinal stem cells. European Journal of Neuroscience. 18(1):76-84. :...download in .pdf ...:
2002
Nuttley, W.M., Atkinson-Leadbeater, K.P., van der Kooy, D. (2002). Serotonin mediates food-odor associative learning in the nematode Caenorhabditiselegans. Proceedings of the National Academy of Sciences USA. 99(19):12449-54. :...download in .pdf ...:
2001
Tropepe, V., Hitoshi, S., Sirard, C., Mak, T., Rossant, J., van der Kooy, D. (2001). Direct neural fate specification from embryonic stem cells: a primitive mammalian neural stem cell stage acquired through a default mechanism. Neuron. 30(1): 65-78. :...download in .pdf ...:
Tropepe, V., Coles, B.L., Chiasson, B.J., Horsford, D.J., Elia, A.J., McInnes, R.R., van der Kooy, D. (2000). Retinal stem cells in the adult mammalian eye. Science. 287: 2032-6. :...download in .pdf ...:
2000
van der Kooy, D., & Weiss, S. (2000). Why Stem Cells? Science. 287: 1439-41. :...download in .pdf ...:
**photo credit: Sandrine Willaime-Morawek**