[MacLennan Lab] [UofT]
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+ Ca 2+ ATPase
+ Phospholamban, Sarcolipin
+ Brody Disease
+ Cardiomyopathy
+ Ca2+ Release Channel
+ Ca2+ Binding Proteins


MacLennan Lab Research Interests

The overall objectives of research in our laboratory are to understand how normal sarcoplasmic reticulum proteins carry out their functions of calcium transport, sequestration and release and how mutant forms cause abnormalities or disease.  In order to accomplish these objectives, we have isolated many of the sarcoplasmic reticulum proteins and characterized them.  We have also utilized recombinant DNA technology to advance our knowledge of the primary structures of these proteins, of their mechanisms of action, and of the roles that mutant proteins play in human genetic disease.

The specific areas of research focus are:


+ Research
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