[MacLennan Lab] [UofT]
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+ Ca 2+ ATPase
+ Phospholamban, Sarcolipin
+ Brody Disease
+ Cardiomyopathy
+ Ca2+ Release Channel
+ MH/CCD
+ Ca2+ Binding Proteins
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MacLennan Lab Publications

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  1. Leong, P. and MacLennan, D.H. (1998) A 37 amino acid sequence in the skeletal muscle ryanodine receptor interacts with the cytoplasmic loop between domains II and III in the skeletal muscle dihydropyridine receptor. Journal of Biological Chemistry (in press)
  2. MacLennan, D.H. and Britt, B.A. (1998) Malignant hyperthermia and central core disease, in Principles of Molecular Medicine (Jameson, J.L.)
  3. Loke, J. and MacLennan, D.H. (1998) Malignant hyperthermia and central core disease: disorders of Ca2+ release channels. American Journal of Medicine (in press)
  4. Odermatt, A., Becker, S., Khanna, V.K., Kurzydlowski, K., Leisner, E., Pette, D. and MacLennan, D.H. (1998) Sarcolipin regulates the activity of SERCA1, the fast-twitch skeletal muscle sarcoplasmic reticulum Ca2+ ATPase. Journal of Biological Chemistry 273(in press)
  5. MacLennan, D.H., Kimura, Y. and Toyofuku, T. (1998) Sites of regulatory interaction between calcium ATPases and phospholamban. Annals of the New York Academy of Science (in press)
 
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  1. MacLennan, D.H., Loke, J. and Odermatt, A. (1997) The role of genes encoding sarcoplasmic reticulum proteins in malignant hyperthermia, central core disease and Brody disease, in Calcium as a Cellular Regulator (Carafoli, E. and Klee, C.) Oxford University Press New York
  2. Tong, J., Oyamada, H., Demaurex, N., Grinstein, S., McCarthy, T.V. and MacLennan, D.H. (1997) Caffeine and halothane sensitivity of intracellular Ca2+ release is altered by 15 calcium release channel (ryanodine receptor) mutations associated with malignant hyperthermia and/or central core disease. J Biol Chem 272(42):26332-9
  3. Imredy, J., Chen, S.R.W., Leong, P., Bartlett, C., Zhang, L. and MacLennan, D.H. (1997) Voltage-sensitive rectification of the Ca2+ release channel of the skeletal muscle sarcoplasmic reticulum (ryanodine receptor) expressed in HEK-293 cells. (submitted)
  4. Chen, S.R., Leong, P., Imredy, J.P., Bartlett, C., Zhang, L. and MacLennan, D.H. (1997) Single-channel properties of the recombinant skeletal muscle Ca2+ release channel (ryanodine receptor). Biophys J 73(4):1904-12
  5. Odermatt, A., Taschner, P.E., Scherer, S.W., Beatty, B., Khanna, V.K., Cornblath, D.R., Chaudhry, V., Yee, W.C., Schrank, B., Karpati, G., Breuning, M.H., Knoers, N. and MacLennan, D.H. (1997) Characterization of the gene encoding human sarcolipin (SLN), a proteolipid associated with SERCA1: absence of structural mutations in five patients with Brody disease. Genomics 45(3):541-53
  6. Rice, W.J., Green, N.M. and MacLennan, D.H. (1997) Site-directed disulfide mapping of helices M4 and M6 in the Ca2+ binding domain of SERCA1a, the Ca2+ ATPase of fast twitch skeletal muscle sarcoplasmic reticulum. J Biol Chem 272(50):31412-9
  7. Liu, L.H., Paul, R.J., Sutliff, R.L., Miller, M.L., Lorenz, J.N., Pun, R.Y., Duffy, J.J., Doetschman, T., Kimura, Y., MacLennan, D.H., Hoying, J.B. and Shull, G.E. (1997) Defective endothelium-dependent relaxation of vascular smooth muscle and endothelial cell Ca2+ signaling in mice lacking sarco(endo)plasmic reticulum Ca2+-ATPase isoform 3. J Biol Chem 272(48):30538-45
  8. MacLennan, D.H., Rice, W.J. and Odermatt, A. (1997) Structure/function analysis of the Ca2+ binding and translocation domain of SERCA1 and the role in Brody disease of the ATP2A1 gene encoding SERCA1. Ann N Y Acad Sci 834175-85
  9. MacLennan, D.H., Rice, W.J. and Green, N.M. (1997) The mechanism of Ca2+ transport by sarco(endo)plasmic reticulum Ca2+- ATPases. J Biol Chem 272(46):28815-8
  10. MacLennan, D.H., Rice, W.J. and Odermatt, A. (1997) Structure-function analysis of the Ca2+ binding and translocation domain of SERCA1 and the role of Brody disease of the ATP2A1 gene encoding SERCA1. New York Acad. Sci. (in press)
  11. Loke, J.C.P., Britt, B.A. and MacLennan, D.H. (1997) Bayesian modelling of muscle biopsy contracture testing for malignant hyperthermia. Anesthesiology ((in press)):
  12. Kimura, Y., Kurzydlowski, K., Tada, M. and MacLennan, D.H. (1997) Phospholamban inhibitory function is activated by depolymerization. Journal of Biological Chemistry 272(24):15061-4
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  1. Odermatt, A., Taschner, P.E.M., Khanna, V.K., Busch, H.F.M., Karpati, G., Jablecki, C.K., Breuning, M.H. and MacLennan, D.H. (1996) Mutations in the gene encoding SERCA1, the fast-twitch skeletal muscle sarcoplasmic reticulum Ca2+ ATPase, are associated with Brody disease. Nature Genetics 14191-4
  2. MacLennan, D.H. and Britt, B.A. (1996) Malignant hyperthermia and central core disease: Genetic and physiological basis, in Textbook of Molecular Medicine (Jameson, J.L.) Blackwell Scientific Publication Inc. Cambridge
  3. MacLennan, D.H., Phillips, M.S. and Britt, B.A. (1996) The molecular and genetic basis for malignant hyperthermia and central core disease, in The Molecular and Genetic Basis of Neurological Disease (Rosenberg, R.N., Prusiner, S.B., DiMauro, S. and Barchi, R.L.) Butterworth Heinemann Newton, MA
  4. MacLennan, D.H., Phillips, M.S. and Zhang, Y. (1996) The genetic and physiological basis of malignant hyperthermia, in Molecular Biology of Membrane Transport Disorders (Schultz, S.G., Andreoli, T.E., Brown, A.M., Fambrough, D., Hoffman, J. and M.J. Welsh) Plenum Press New York
  5. Phillips, M.S., Fujii, J., Khanna, V.K., DeLeon, S., Yokobata, K., de Jong, P. and MacLennan, D.H. (1996) The structural organization of the human skeletal muscle ryanodine receptor (RYR1) gene. Genomics 34(1):24-41
  6. Serfas, K.D., Bose, D., Patel, L., Wrogemann, K., Phillips, M.S., MacLennan, D.H. and Greenberg, C.R. (1996) Comparison of the segregation of the RYR1 C1840T mutation with segregation of the caffeine/halothane contracture test results for malignant hyperthermia susceptibility in a large Manitoba Mennonite family [see comments]. Anesthesiology 84(2):322-9
  7. Kimura, Y., Kurzydlowski, K., Tada, M. and MacLennan, D.H. (1996) Phospholamban regulates the Ca2+-ATPase through intramembrane interactions. Journal of Biological Chemistry 271(36):21726-31
  8. MacLennan, D.H. and Becker, S.J. (1996) Sarcoplasmic reticulum Ca2+ ATPases, in Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters (Morad, M., Ebashi, S., Trautwein, W. and Kurachi, Y.) Kluwer Academic Publishers Dordrecht, Holland
  9. Rice, W.J. and MacLennan, D.H. (1996) Scanning mutagenesis reveals a similar pattern of mutation sensitivity in transmembrane sequences M4, M5 and M6, but not in M8 of the Ca2+-ATPase of sarcoplasmic reticulum (SERCA1a). Journal of Biological Chemistry 271(49):31412-31419
  10. Odermatt, A., Kurzydlowski, K. and MacLennan, D.H. (1996) The vmax of the Ca2+-ATPase of cardiac sarcoplasmic reticulum (SERCA2a) is not altered by Ca2+/calmodulin-dependent phosphorylation or by interaction with phospholamban. Journal of Biological Chemistry 271(24):14206-13
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  1. Matsui, H., MacLennan, D.H., Alpert, N.R. and Periasamy, M. (1995) Sarcoplasmic reticulum gene expression in pressure overload-induced cardiac hypertrophy in rabbit. American Journal of Physiology 268(1 Pt 1):C252-8
  2. Zhang, Y.L., Fujii, J., Phillips, M.S., Chen, H.-S., Karpati, G., Yee, W.-C., Schrank, B., Cornblath, D.R., Boylan, K.B. and MacLennan, D.H. (1995) Characterization of cDNA and genomic DNA encoding SERCA1, the Ca2+ ATPase of human fast-twitch skeletal muscle sarcoplasmic reticulum and its elimination as a candidate gene for Brody disease in three patients. Genomics 30(3):415-24
  3. MacLennan, D.H. (1995) Discordance between phenotype and genotype in malignant hyperthermia. Current Opinion in Neurology 8(5):397-401
  4. MacLennan, D.H. and Phillips, M.S. (1995) The role of the skeletal muscle ryanodine receptor gene in malignant hyperthermia and central core disease, in Ryanodine Receptors (Sorrentino, V.) CRC Press Boca Raton
  5. MacLennan, D.H. and Phillips, M.S. (1995) The role of the skeletal muscle ryanodine receptor (RYR1) gene in malignant hyperthermia and central core disease, in Ion Channels and Genetic Diseases (Dawson, D.C. and Frizzell, R.A.) Rockefeller University Press New York
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  1. Phillips, M.S., Khanna, V.K., De Leon, S., Frodis, W., Britt, B.A. and MacLennan, D.H. (1994) The substitution of Arg for Gly2433 in the human skeletal muscle ryanodine receptor is associated with malignant hyperthermia. Human Molecular Genetics 3(12):2181-6
  2. Toyofuku, T., Kurzydlowski, K., Tada, M. and MacLennan, D.H. (1994) Amino acids Lys-Asp-Asp-Lys-Pro-Val402 in the Ca(2+)-ATPase of cardiac sarcoplasmic reticulum are critical for functional association with phospholamban. Journal of Biological Chemistry 269(37):22929-32
  3. Toyofuku, T., Kurzydlowski, K., Tada, M. and MacLennan, D.H. (1994) Amino acids Glu2 to Ile18 in the cytoplasmic domain of phospholamban are essential for functional association with the Ca(2+)-ATPase of sarcoplasmic reticulum. Journal of Biological Chemistry 269(4):3088-94
  4. Chen, S.R., Zhang, L. and MacLennan, D.H. (1994) Asymmetrical blockade of the Ca2+ release channel (ryanodine receptor) by 12-kDa FK506 binding protein. Proceedings of the National Academy of Sciences of the United States of America 91(25):11953-7
  5. Chen, S.R. and MacLennan, D.H. (1994) Identification of calmodulin-, Ca(2+)-, and ruthenium red-binding domains in the Ca2+ release channel (ryanodine receptor) of rabbit skeletal muscle sarcoplasmic reticulum. Journal of Biological Chemistry 269(36):22698-704
  6. Toyofuku, T., Curotto Kurzydlowski, K., Narayanan, N. and MacLennan, D.H. (1994) Identification of Ser38 as the site in cardiac sarcoplasmic reticulum Ca(2+)-ATPase that is phosphorylated by Ca2+/calmodulin-dependent protein kinase. Journal of Biological Chemistry 269(42):26492-6
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  1. Otsu, K., Fujii, J., Periasamy, M., Difilippantonio, M., Uppender, M., Ward, D.C. and MacLennan, D.H. (1993) Chromosome mapping of five human cardiac and skeletal muscle sarcoplasmic reticulum protein genes. Genomics 17(2):507-9
  2. Arai, M., Alpert, N.R., MacLennan, D.H., Barton, P. and Periasamy, M. (1993) Alterations in sarcoplasmic reticulum gene expression in human heart failure. A possible mechanism for alterations in systolic and diastolic properties of the failing myocardium. Circulation Research 72(2):463-9
  3. MacLennan, D.H., Phillips, M.S. and Zhang, Y. (1993) The genetic basis of malignant hyperthermia, in Malignant Hyperthermia: A Genetic Membrane Disease (Ohnishi, S.T. and Ohnishi, T.) CRC Press Boca Raton
  4. Rouquier, S., Giorgi, D., Trask, B., Bergmann, A., Phillips, M.S., MacLennan, D.H. and de Jong, P. (1993) A cosmid and yeast artificial chromosome contig containing the complete ryanodine receptor (RYR1) gene. Genomics 17(2):330-40
  5. Zhang, Y., Chen, H.S., Khanna, V.K., De Leon, S., Phillips, M.S., Schappert, K., Britt, B.A., Browell, A.K. and MacLennan, D.H. (1993) A mutation in the human ryanodine receptor gene associated with central core disease. Nature Genetics 5(1):46-50
  6. Schwemmle, S., Wolff, K., Palmucci, L.M., Grimm, T., Lehmann-Horn, F., Hubner, C., Hauser, E., Iles, D.E., MacLennan, D.H. and Muller, C.R. (1993) Multipoint mapping of the central core disease locus. Genomics 17(1):205-7
  7. Mulley, J.C., Kozman, H.M., Phillips, H.A., Gedeon, A.K., McCure, J.A., Iles, D.E., Gregg, R.G., Hogan, K., Couch, F.J., MacLennan, D.H. and et al. (1993) Refined genetic localization for central core disease. American Journal of Human Genetics 52(2):398-405
  8. Toyofuku, T., Kurzydlowski, K., Tada, M. and MacLennan, D.H. (1993) Identification of regions in the Ca(2+)-ATPase of sarcoplasmic reticulum that affect functional association with phospholamban. Journal of Biological Chemistry 268(4):2809-15
  9. MacLennan, D.H. and Chen, S.R.W. (1993) The role of the calcium release channel of skeletal muscle sarcoplasmic reticulum in malignant hyperthermia. Ann N.Y. Acad Sci 707294-304
  10. Chen, S.R., Airey, J.A. and MacLennan, D.H. (1993) Positioning of major tryptic fragments in the Ca2+ release channel (ryanodine receptor) resulting from partial digestion of rabbit skeletal muscle sarcoplasmic reticulum. Journal of Biological Chemistry 268(30):22642-9
  11. Chen, S.R., Zhang, L. and MacLennan, D.H. (1993) Antibodies as probes for Ca2+ activation sites in the Ca2+ release channel (ryanodine receptor) of rabbit skeletal muscle sarcoplasmic reticulum. Journal of Biological Chemistry 268(18):13414-21
  12. Chen, S.R., Vaughan, D.M., Airey, J.A., Coronado, R. and MacLennan, D.H. (1993) Functional expression of cDNA encoding the Ca2+ release channel (ryanodine receptor) of rabbit skeletal muscle sarcoplasmic reticulum in COS-1 cells. Biochemistry 32(14):3743-53
  13. Skerjanc, I.S., Clarke, D.M., Loo, T.W. and MacLennan, D.H. (1993) Deletion of NH2- and COOH-terminal sequences destroys function of the Ca2+ ATPase of rabbit fast-twitch skeletal muscle sarcoplasmic reticulum. FEBS Letters 336(1):168-70
  14. Clarke, D.M., Loo, T.W., Rice, W.J., Andersen, J.P., Vilsen, B. and MacLennan, D.H. (1993) Functional consequences of alterations to hydrophobic amino acids located in the M4 transmembrane sector of the Ca(2+)-ATPase of sarcoplasmic reticulum. Journal of Biological Chemistry 268(24):18359-64
  15. Skerjanc, I.S., Toyofuku, T., Richardson, C. and MacLennan, D.H. (1993) Mutation of glutamate 309 to glutamine alters one Ca(2+)-binding site in the Ca(2+)-ATPase of sarcoplasmic reticulum expressed in Sf9 cells. Journal of Biological Chemistry 268(21):15944-50
  16. Arai, M., Otsu, K., MacLennan, D.H. and Periasamy, M. (1992) Regulation of sarcoplasmic reticulum gene expression during cardiac and skeletal muscle development. American Journal of Physiology 262(3 Pt 1):C614-20
  17. Lytton, J. and MacLennan, D.H. (1992) ATP dependent cation pumps of the heart, in Molecular Basis of Cardiology (Roberts, R.) Blackwell Scientific Publications Boston
  18. Lytton, J. and MacLennan, D.H. (1992) Sarcoplasmic reticulum, in The Heart and Cardiovascular System: Scientific Foundations (Fozzard, H.A., Haber, E., Jennings, R.B., Katz, A.M. and Morgan, H.E.) Raven Press New York
  19. MacLennan, D.H., Otsu, K., Fujii, J., Zorzato, F., Phillips, M.S., PJ, O.B., Archibald, A.L., Britt, B.A., Gillard, E.F. and Worton, R.G. (1992) The role of the skeletal muscle ryanodine receptor gene in malignant hyperthermia. Symposia of the Society for Experimental Biology 46189-201
  20. MacLennan, D.H. (1992) The genetic basis of malignant hyperthermia. Trends in Pharmacological Sciences 13(8):330-4
  21. Deufel, T., Golla, A., Iles, D., Meindl, A., Meitinger, T., Schindelhauer, D., DeVries, A., Pongratz, D., MacLennan, D.H., Johnson, K.J. and et al. (1992) Evidence for genetic heterogeneity of malignant hyperthermia susceptibility. American Journal of Human Genetics 50(6):1151-61
  22. Gillard, E.F., Otsu, K., Fujii, J., Duff, C., de Leon, S., Khanna, V.K., Britt, B.A., Worton, R.G. and MacLennan, D.H. (1992) Polymorphisms and deduced amino acid substitutions in the coding sequence of the ryanodine receptor (RYR1) gene in individuals with malignant hyperthermia. Genomics 13(4):1247-54
  23. Otsu, K., Phillips, M.S., Khanna, V.K., de Leon, S. and MacLennan, D.H. (1992) Refinement of diagnostic assays for a probable causal mutation for porcine and human malignant hyperthermia. Genomics 13(3):835-7
  24. MacLennan, D.H. and Phillips, M.S. (1992) Malignant hyperthermia. Science 256(5058):789-94
  25. MacLennan, D.H. and Toyofuku, T. (1992) Structure-function relationships in the Ca2+ pump of the sarcoplasmic reticulum. Biochemical Society Transactions 20(3):559-62
  26. Chen, S.R., Zhang, L. and MacLennan, D.H. (1992) Characterization of a Ca2+ binding and regulatory site in the Ca2+ release channel (ryanodine receptor) of rabbit skeletal muscle sarcoplasmic reticulum. Journal of Biological Chemistry 267(32):23318-26
  27. MacLennan, D.H., Toyofuku, T. and Lytton, J. (1992) Structure-function relationships in sarcoplasmic or endoplasmic reticulum type Ca2+ pumps. Annals of the New York Academy of Sciences 6711-10
  28. Toyofuku, T., Kurzydlowski, K., Lytton, J. and MacLennan, D.H. (1992) The nucleotide binding/hinge domain plays a crucial role in determining isoform-specific Ca2+ dependence of organellar Ca(2+)-ATPases. Journal of Biological Chemistry 267(20):14490-6
  29. MacLennan, D.H., Clarke, D.M., Loo, T.W. and Skerjanc, I.S. (1992) Site-directed mutagenesis of the Ca2+ ATPase of sarcoplasmic reticulum. Acta Physiologica Scandinavica. Supplementum 607141-50
  30. Lytton, J., Westlin, M., Burk, S.E., Shull, G.E. and MacLennan, D.H. (1992) Functional comparisons between isoforms of the sarcoplasmic or endoplasmic reticulum family of calcium pumps. Journal of Biological Chemistry 267(20):14483-9
  31. Clarke, D.M., Maruyama, K., Loo, T.W. and MacLennan, D.H. (1992) Molecular biology of sarcoplasmic reticulum proteins involved in EC coupling, in Molecular Biology of the Myocardium (Tada, M.) Japan Scientific Societies Press Tokyo
  32. Andersen, J.P., Vilsen, B. and MacLennan, D.H. (1992) Functional consequences of alterations to Gly310, Gly770, and Gly801 located in the transmembrane domain of the Ca(2+)-ATPase of sarcoplasmic reticulum. Journal of Biological Chemistry 267(4):2767-74
  33. Arai, M., Otsu, K., MacLennan, D.H., Alpert, N.R. and Periasamy, M. (1991) Effect of thyroid hormone on the expression of mRNA encoding sarcoplasmic reticulum proteins. Circulation Research 69(2):266-76
  34. Callen, D.F., Baker, E., Lane, S., Nancarrow, J., Thompson, A., Whitmore, S.A., MacLennan, D.H., Berger, R., Cherif, D., Jarvela, I. and et al. (1991) Regional mapping of the Batten disease locus (CLN3) to human chromosome 16p12. American Journal of Human Genetics 49(6):1372-7
  35. Gillard, E.F., Otsu, K., Fujii, J., Khanna, V.K., de Leon, S., Derdemezi, J., Britt, B.A., Duff, C.L., Worton, R.G. and MacLennan, D.H. (1991) A substitution of cysteine for arginine 614 in the ryanodine receptor is potentially causative of human malignant hyperthermia. Genomics 11(3):751-5
  36. Otsu, K., Khanna, V.K., Archibald, A.L. and MacLennan, D.H. (1991) Cosegregation of porcine malignant hyperthermia and a probable causal mutation in the skeletal muscle ryanodine receptor gene in backcross families. Genomics 11(3):744-50
  37. Fujii, J., Otsu, K., Zorzato, F., de Leon, S., Khanna, V.K., Weiler, J.E., PJ, O.B. and MacLennan, D.H. (1991) Identification of a mutation in porcine ryanodine receptor associated with malignant hyperthermia. Science 253(5018):448-51
  38. MacKenzie, A.E., Allen, G., Lahey, D., Crossan, M.L., Nolan, K., Mettler, G., Worton, R.G., MacLennan, D.H. and Korneluk, R. (1991) A comparison of the caffeine halothane muscle contracture test with the molecular genetic diagnosis of malignant hyperthermia. Anesthesiology 75(1):4-8
  39. Fujii, J., Zarain-Herzberg, A., Willard, H.F., Tada, M. and MacLennan, D.H. (1991) Structure of the rabbit phospholamban gene, cloning of the human cDNA, and assignment of the gene to human chromosome 6. Journal of Biological Chemistry 266(18):11669-75
  40. Vilsen, B., Andersen, J.P. and MacLennan, D.H. (1991) Functional consequences of alterations to hydrophobic amino acids located at the M4S4 boundary of the Ca(2+)-ATPase of sarcoplasmic reticulum. Journal of Biological Chemistry 266(28):18839-45
  41. Vilsen, B., Andersen, J.P. and MacLennan, D.H. (1991) Functional consequences of alterations to amino acids located in the hinge domain of the Ca(2+)-ATPase of sarcoplasmic reticulum. Journal of Biological Chemistry 266(24):16157-64
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  1. Fujii, J., Willard, H.F. and MacLennan, D.H. (1990) Characterization and localization to human chromosome 1 of human fast-twitch skeletal muscle calsequestrin gene. Somatic Cell & Molecular Genetics 16(2):185-9
  2. Leberer, E., Timms, B.G., Campbell, K.P. and MacLennan, D.H. (1990) Purification, calcium binding properties, and ultrastructural localization of the 53,000- and 160,000 (sarcalumenin)-dalton glycoproteins of the sarcoplasmic reticulum. Journal of Biological Chemistry 265(17):10118-24
  3. Zarain-Herzberg, A., Lytton, J., Nagai, R., Alpert, N.R., MacLennan, D.H. and Periasamy, M. (1990) Regulation of cardiac sarcoplasmic reticulum Ca2+-ATPase gene expression, in UCLA Symposium on Molecular and Cellular Biology, New Series, Molecular Biology of the Cardiovascular System (Roberts, R. and Schneider, M.D.) Alan R. Liss Inc. New York
  4. Zarain-Herzberg, A., MacLennan, D.H. and Periasamy, M. (1990) Characterization of rabbit cardiac sarco(endo)plasmic reticulum Ca2(+)-ATPase gene. Journal of Biological Chemistry 265(8):4670-7
  5. MacKenzie, A.E., Korneluk, R.G., Zorzato, F., Fujii, J., Phillips, M., Iles, D., Wieringa, B., Leblond, S., Bailly, J., Willard, H.F., Duff, C., Worton, R.G. and MacLennan, D.H. (1990) The human ryanodine receptor gene: its mapping to 19q13.1, placement in a chromosome 19 linkage group and exclusion as the gene causing myotonic dystrophy. American Journal of Human Genetics 46(6):1082-9
  6. MacLennan, D.H., Duff, C., Zorzato, F., Fujii, J., Phillips, M., Korneluk, R.G., Frodis, W., Britt, B.A. and Worton, R.G. (1990) Ryanodine receptor gene is a candidate for predisposition to malignant hyperthermia. Nature 343(6258):559-61
  7. Fujii, J., Maruyama, K., Tada, M. and MacLennan, D.H. (1990) Co-expression of slow-twitch/cardiac muscle Ca2(+)-ATPase (SERCA2) and phospholamban. FEBS Letters 273(1-2):232-4
  8. Otsu, K., Willard, H.F., Khanna, V.K., Zorzato, F., Green, N.M. and MacLennan, D.H. (1990) Molecular cloning of cDNA encoding the Ca2+ release channel (ryanodine receptor) of rabbit cardiac muscle sarcoplasmic reticulum. Journal of Biological Chemistry 265(23):13472-83
  9. Zorzato, F., Fujii, J., Otsu, K., Phillips, M., Green, N.M., Lai, F.A., Meissner, G. and MacLennan, D.H. (1990) Molecular cloning of cDNA encoding human and rabbit forms of the Ca2+ release channel (ryanodine receptor) of skeletal muscle sarcoplasmic reticulum. Journal of Biological Chemistry 265(4):2244-56
  10. Clarke, D.M., Loo, T.W. and MacLennan, D.H. (1990) Functional consequences of alterations to amino acids located in the nucleotide binding domain of the Ca2(+)-ATPase of sarcoplasmic reticulum. Journal of Biological Chemistry 265(36):22223-7
  11. MacLennan, D.H. (1990) Molecular tools to elucidate problems in excitation-contraction coupling. Biophysical Journal 58(6):1355-65
  12. Clarke, D.M., Loo, T.W. and MacLennan, D.H. (1990) The epitope for monoclonal antibody A20 (amino acids 870-890) is located on the luminal surface of the Ca2(+)-ATPase of sarcoplasmic reticulum. Journal of Biological Chemistry 265(29):17405-8
  13. Clarke, D.M., Loo, T.W. and MacLennan, D.H. (1990) Functional consequences of mutations of conserved amino acids in the beta-strand domain of the Ca2(+)-ATPase of sarcoplasmic reticulum. Journal of Biological Chemistry 265(24):14088-92
  14. Clarke, D.M., Loo, T.W. and MacLennan, D.H. (1990) Functional consequences of alterations to polar amino acids located in the transmembrane domain of the Ca2(+)-ATPase of sarcoplasmic reticulum. Journal of Biological Chemistry 265(11):6262-7
  15. Fliegel, L., Burns, K., MacLennan, D.H., Reithmeier, R.A. and Michalak, M. (1989) Molecular cloning of the high affinity calcium-binding protein (calreticulin) of skeletal muscle sarcoplasmic reticulum. Journal of Biological Chemistry 264(36):21522-8
  16. Leberer, E., Charuk, J.H., Green, N.M. and MacLennan, D.H. (1989) Molecular cloning and expression of cDNA encoding a lumenal calcium binding glycoprotein from sarcoplasmic reticulum. Proceedings of the National Academy of Sciences of the United States of America 86(16):6047-51
  17. Leberer, E., Charuk, J.H., Clarke, D.M., Green, N.M., Zubrzycka-Gaarn, E. and MacLennan, D.H. (1989) Molecular cloning and expression of cDNA encoding the 53,000-dalton glycoprotein of rabbit skeletal muscle sarcoplasmic reticulum. Journal of Biological Chemistry 264(6):3484-93
  18. Fliegel, L., Leberer, E., Green, N.M. and MacLennan, D.H. (1989) The fast-twitch muscle calsequestrin isoform predominates in rabbit slow-twitch soleus muscle. FEBS Letters 242(2):297-300
  19. Nagai, R., Zarain-Herzberg, A., Brandl, C.J., Fujii, J., Tada, M., MacLennan, D.H., Alpert, N.R. and Periasamy, M. (1989) Regulation of myocardial Ca2+-ATPase and phospholamban mRNA expression in response to pressure overload and thyroid hormone. Proceedings of the National Academy of Sciences of the United States of America 86(8):2966-70
  20. Fujii, J., Maruyama, K., Tada, M. and MacLennan, D.H. (1989) Expression and site-specific mutagenesis of phospholamban. Studies of residues involved in phosphorylation and pentamer formation. Journal of Biological Chemistry 264(22):12950-5
  21. Vilsen, B., Andersen, J.P., Clarke, D.M. and MacLennan, D.H. (1989) Functional consequences of proline mutations in the cytoplasmic and transmembrane sectors of the Ca2(+)-ATPase of sarcoplasmic reticulum. Journal of Biological Chemistry 264(35):21024-30
  22. Andersen, J.P., Vilsen, B., Leberer, E. and MacLennan, D.H. (1989) Functional consequences of mutations in the beta-strand sector of the Ca2(+)-ATPase of sarcoplasmic reticulum. Journal of Biological Chemistry 264(35):21018-23
  23. Burk, S.E., Lytton, J., MacLennan, D.H. and Shull, G.E. (1989) cDna cloning, functional expression, and mRna tissue distribution of a third organellar Ca2+ pump. Journal of Biological Chemistry 264(31):18561-8
  24. Maruyama, K., Clarke, D.M., Fujii, J., Loo, T.W. and MacLennan, D.H. (1989) Expression and mutation of Ca2+ ATPases of the sarcoplasmic reticulum. Cell Motility & the Cytoskeleton 14(1):26-34
  25. Maruyama, K., Clarke, D.M., Fujii, J., Inesi, G., Loo, T.W. and MacLennan, D.H. (1989) Functional consequences of alterations to amino acids located in the catalytic center (isoleucine 348 to threonine 357) and nucleotide-binding domain of the Ca2+-ATPase of sarcoplasmic reticulum. Journal of Biological Chemistry 264(22):13038-42
  26. Clarke, D.M., Maruyama, K., Loo, T.W., Leberer, E., Inesi, G. and MacLennan, D.H. (1989) Functional consequences of glutamate, aspartate, glutamine, and asparagine mutations in the stalk sector of the Ca2+-ATPase of sarcoplasmic reticulum. Journal of Biological Chemistry 264(19):11246-51
  27. Clarke, D.M., Loo, T.W., Inesi, G. and MacLennan, D.H. (1989) Location of high affinity Ca2+-binding sites within the predicted transmembrane domain of the sarcoplasmic reticulum Ca2+-ATPase. Nature 339(6224):476-8
  28. Lytton, J., Zarain-Herzberg, A., Periasamy, M. and MacLennan, D.H. (1989) Molecular cloning of the mammalian smooth muscle sarco(endo)plasmic reticulum Ca2+-ATPase. Journal of Biological Chemistry 264(12):7059-65
  29. Green, N.M. and MacLennan, D.H. (1989) ATP driven ion pumps: an evolutionary mosaic. Biochemical Society Transactions 17(5):819-22
  30. Tuana, B.S. and MacLennan, D.H. (1988) Isolation of the calmodulin-dependent protein kinase system from rabbit skeletal muscle sarcoplasmic reticulum. FEBS Letters 235(1-2):219-23
  31. Zarain-Herzberg, A., Fliegel, L. and MacLennan, D.H. (1988) Structure of the rabbit fast-twitch skeletal muscle calsequestrin gene. Journal of Biological Chemistry 263(10):4807-12
  32. Korczak, B., Zarain-Herzberg, A., Brandl, C.J., Ingles, C.J., Green, N.M. and MacLennan, D.H. (1988) Structure of the rabbit fast-twitch skeletal muscle Ca2+-ATPase gene. Journal of Biological Chemistry 263(10):4813-9
  33. Fujii, J., Lytton, J., Tada, M. and MacLennan, D.H. (1988) Rabbit cardiac and slow-twitch muscle express the same phospholamban gene. FEBS Letters 227(1):51-5
  34. Maruyama, K. and MacLennan, D.H. (1988) Mutation of aspartic acid-351, lysine-352, and lysine-515 alters the Ca2+ transport activity of the Ca2+-ATPase expressed in COS-1 cells. Proceedings of the National Academy of Sciences of the United States of America 85(10):3314-8
  35. Green, N.M., Taylor, W.R. and MacLennan, D.H. (1988) A consensus structure for cation pumps, in Ion Pumps, Structure, Function and Regulation (Stein, W.D. and Karlish, S.J.) Alan R. Liss New York
  36. Lytton, J. and MacLennan, D.H. (1988) Molecular cloning of cDNAs from human kidney coding for two alternatively spliced products of the cardiac Ca2+-ATPase gene. Journal of Biological Chemistry 263(29):15024-31
  37. Reithmeier, R.A.F., Ohnishi, M., Carpenter, M.R., Slupsky, J.R., Gounden, K., Fliegel, L., Khanna, V.K. and MacLennan, D.H. (1987) Calsequestrin, in Calcium Binding Proteins in Health and Disease (Norman, A.W., Vanaman, T.C. and Means, A.R.) Academic Press New York
  38. Fliegel, L., Ohnishi, M., Carpenter, M.R., Khanna, V.K., Reithmeier, R.A. and MacLennan, D.H. (1987) Amino acid sequence of rabbit fast-twitch skeletal muscle calsequestrin deduced from cDNA and peptide sequencing. Proceedings of the National Academy of Sciences of the United States of America 84(5):1167-71
  39. MacLennan, D.H., Brandl, C.J., Champaneria, S., Holland, P.C., Powers, V.E. and Willard, H.F. (1987) Fast-twitch and slow-twitch/cardiac Ca2+ ATPase genes map to human chromosomes 16 and 12. Somatic Cell & Molecular Genetics 13(4):341-6
  40. Brandl, C.J., deLeon, S., Martin, D.R. and MacLennan, D.H. (1987) Adult forms of the Ca2+ATPase of sarcoplasmic reticulum. Expression in developing skeletal muscle. Journal of Biological Chemistry 262(8):3768-74
  41. MacLennan, D.H., Brandl, C.J., Korczak, B. and Green, N.M. (1986) Calcium ATPases: Contribution of molecular genetics to our understanding of structure and function, in Proteins of Excitable Membranes (Hille, B. and Fambrough, D.) Wiley New York
  42. Brandl, C.J., Green, N.M., Korczak, B. and MacLennan, D.H. (1986) Two Ca2+ ATPase genes: homologies and mechanistic implications of deduced amino acid sequences. Cell 44(4):597-607
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+ 1980
+ Earliest

  1. MacLennan, D.H., Brandl, C.J., Korczak, B. and Green, N.M. (1985) Amino-acid sequence of a Ca2+ + Mg2+-dependent ATPase from rabbit muscle sarcoplasmic reticulum, deduced from its complementary DNA sequence. Nature 316(6030):696-700
  2. MacLennan, D. and Reithmeier, R. (1985) Structural analysis of the Ca2++Mg2+-ATPase of sarcoplasmic reticulum, in Structure and Function of Sarcoplasmic Reticulum (Fleischer, S. and Tonomura, Y.) Academic Press New York
  3. Campbell, K.P., MacLennan, D.H., Jorgensen, A.O. and Mintzer, M.C. (1983) Purification and characterization of calsequestrin from canine cardiac sarcoplasmic reticulum and identification of the 53,000 dalton glycoprotein. Journal of Biological Chemistry 258(2):1197-204
  4. Shoshan, V., MacLennan, D.H. and Wood, D.S. (1983) Tetraphenylboron causes Ca2+ release in isolated sarcoplasmic reticulum and in skinned muscle fibers. Journal of Biological Chemistry 258(5):2837-42
  5. Campbell, K.P. and MacLennan, D.H. (1982) A calmodulin-dependent protein kinase system from skeletal muscle sarcoplasmic reticulum. Phosphorylation of a 60,000-dalton protein. Journal of Biological Chemistry 257(3):1238-46
  6. MacLennan, D.H. and Reithmeier, R.A.F. (1982) The structure of the Ca2+/Mg2+-ATPase of sarcoplasmic reticulum, in Membranes and Transport (Martonosi, A.N.) Plenum Press New York
  7. Campbell, K.P. and MacLennan, D.H. (1981) Purification and characterization of the 53,000-dalton glycoprotein from the sarcoplasmic reticulum. Journal of Biological Chemistry 256(9):4626-32
  8. Shoshan, V., MacLennan, D.H. and Wood, D.S. (1981) A proton gradient controls a calcium-release channel in sarcoplasmic reticulum. Proceedings of the National Academy of Sciences of the United States of America 78(8):4828-32
  9. Reithmeier, R.A. and MacLennan, D.H. (1981) The NH2 terminus of the (Ca2+ + Mg2+)-adenosine triphosphatase is located on the cytoplasmic surface of the sarcoplasmic reticulum membrane. Journal of Biological Chemistry 256(12):5957-60
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+ Earliest

  1. Michalak, M., Campbell, K.P. and MacLennan, D.H. (1980) Localization of the high affinity calcium binding protein and an intrinsic glycoprotein in sarcoplasmic reticulum membranes. Journal of Biological Chemistry 255(4):1317-26
  2. Shoshan, V., Campbell, K.P., MacLennan, D.H., Frodis, W. and Britt, B.A. (1980) Quercetin inhibits Ca2+ uptake but not Ca2+ release by sarcoplasmic reticulum in skinned muscle fibers. Proceedings of the National Academy of Sciences of the United States of America 77(8):4435-8
  3. Reithmeier, R.A., de Leon, S. and MacLennan, D.H. (1980) Assembly of the sarcoplasmic reticulum. Cell-free synthesis of te Ca2+ + Mg2+-adenosine triphosphatase and calsequestrin. Journal of Biological Chemistry 255(24):11839-46
  4. Klip, A., Reithmeier, R.A. and MacLennan, D.H. (1980) Alignment of the major tryptic fragments of the adenosine triphosphatase from sarcoplasmic reticulum. Journal of Biological Chemistry 255(14):6562-8
  5. Stewart, P.S. and MacLennan, D.H. (1976) Isolation and characterization of tryptic fragments of the adenosine triphosphatase of sarcoplasmic reticulum. Journal of Biological Chemistry 251(3):712-9
  6. Ostwald, T.J., MacLennan, D.H. and Dorrington, K.J. (1974) Effects of cation binding on the conformation of calsequestrin and the high affinity calcium-binding protein of sarcoplasmic reticulum. Journal of Biological Chemistry 249(18):5867-71
  7. Ostwald, T.J. and MacLennan, D.H. (1974) Isolation of a high affinity calcium-binding protein from sarcoplasmic reticulum. Journal of Biological Chemistry 249(3):974-9
  8. MacLennan, D.H. (1974) The Ayerst Award Lecture: Resolution of the calcium transport system of sarcoplasmic reticulum. Can. J. Biochem. 53251-61
  9. Stewart, P.S. and MacLennan, D.H. (1974) Surface particles of sarcoplasmic reticulum membranes. Structural features of the adenosine triphosphatase. Journal of Biological Chemistry 249(3):985-93
  10. MacLennan, D.H., Yip, C.C., Iles, G.H. and Seeman, P. (1972) Isolation of sarcoplasmic reticulum proteins. Cold Spring Harbor Symp. Quant. Biol. 37469-78
  11. MacLennan, D.H. and Wong, P.T. (1971) Isolation of a calcium-sequestering protein from sarcoplasmic reticulum. Proceedings of the National Academy of Sciences of the United States of America 68(6):1231-5
  12. MacLennan, D.H., Seeman, P., Iles, G.H. and Yip, C.C. (1971) Membrane formation by the adenosine triphosphatase of sarcoplasmic reticulum. Journal of Biological Chemistry 246(8):2702-10
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= Earliest

Revised
1998Apr09
  1. Senior, A.E. and MacLennan, D.H. (1970) Mitochondrial "structural protein." A reassessment. Journal of Biological Chemistry 245(19):5086-95
  2. MacLennan, D.H. (1970) Purification and properties of an adenosine triphosphatase from sarcoplasmic reticulum. Journal of Biological Chemistry 245(17):4508-18
  3. MacLennan, D.H. and Asai, J. (1968) Studies on the mitochondrial adenosine triphosphatase system. V. Localization of the oligomycin-sensitivity conferring protein. Biochemical & Biophysical Research Communications 33(3):441-7
  4. MacLennan, D.H. and Tzagoloff, A. (1968) Studies on the mitochondrial adenosine triphosphatase system. IV. Purification and characterization of the oligomycin sensitivity conferring protein. Biochemistry 7(4):1603-10
  5. Tzagoloff, A., Maclennan, D.H. and Byington, K.H. (1968) Studies on the mitochondrial adenosine triphosphatase system. 3. Isolation from the oligomycin-sensitive adenosine triphosphatase complex of the factors which bind F-1 and determine oligomycin sensitivity of bound F-1. Biochemistry 7(4):1596-602
  6. Tzagoloff, A., Byington, K.H. and MacLennan, D.H. (1968) Studies on the mitochondrial adenosine triphosphatase system. II. The isolation and characterization of an oligomycin-sensitive adenosine triphosphatase from bovine heart mitochondria. Journal of Biological Chemistry 243(9):2405-12
  7. MacLennan, D.H., Smoly, J.M. and Tzagoloff, A. (1968) Studies on the mitochondrial adenosine triphosphatase system. I. Restoration of adenosine triphosphate-dependent reactions in salt-extracted submitochondrial particles. Journal of Biological Chemistry 243(7):1589-97
  8. Tzagoloff, A., MacLennan, D.H., McConnell, D.G. and Green, D.E. (1967) Studies on the electron transfer system. 68. Formation of membranes as the basis of the reconstitution of the mitochondrial electron transfer system. Journal of Biological Chemistry 242(9):2051-61
  9. McConnell, D.G., Tzagoloff, A., MacLennan, D.H. and Green, D.E. (1966) Studies on the electron transfer system. LXV. Formation of membranes by purified cytochrome oxidase. Journal of Biological Chemistry 241(10):2373-82