[ About Us]
Research in the Liu lab aims to develop novel strategies for the effective control of tuberculosis (TB). TB, AIDS, and malaria are the so called ‘Big Three’ infectious diseases of global significance. Currently one-third of the world population is latently infected with TB and 2 million people die from TB each year. The increasing incidents of multiple-drug resistant TB (MDR-TB) and extensively-drug resistant TB (XDR-TB) and the deadly combination of TB-HIV coinfections have placed enormous challenge to current TB control program. As such, new therapeutic interventions and vaccination technology are urgently needed.
Central to the success of Mycobacterium tuberculosis (M. tb) as a human pathogen is its ability to employ multiple virulence mechanisms to infect and persist in the host for extended period of time. The Liu lab is working on identifying various virulence mechanisms of M. tb, and on understanding how M. tb coordinates these virulence mechanisms to achieve successful human infection and disease progression. In addition, we are working on new strategies for the development of next generation of TB vaccine and novel compounds for new drug development.