Brenda Chow... Graduate Student
The Regulation of Synaptic Vesicle Endocytosis
The Role of Amphiphysin: First discovered in association with synaptic vesicles (SVs) in chick brain, amphiphysin (amp) is believed to be important in SV endocytosis. Biochemical assays demonstrated that Amp binds to proteins involved in SV endocytosis, such as dynamin and clathrin. One model suggests that amp may target proteins to clathrin-coated vesicles. However, the role of amp in SV endocytosis in the in vivo is still largely unknown. We propose to define amp's role in SV endocytosis in vivo, using Drosophila as a model organism.
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