Dr. Howard C. Tenenbaum	Dr. Howard C. Tenenbaum Professor of Periodontology, Faculty of Dentistry Professor of Laboratory Medicine and Pathobiology, Faculty of Medicine Head, Division of Research, Department of Dentistry, Mount Sinai Hospital Professor, Periodontology, Tel Aviv University, Israel Faculty of Dentistry 124 Edward Street, Room 349C Toronto, Ontario, Canada M5G 1G6 Phone: 416 979-4928 x4408 Fax: 416 979-4936 howard.tenenbaum@dentistry.utoronto.ca Curriculum vitae
Current academic / hospital appointments
Head, Division of Research, Department of Dentistry, Mount Sinai Hospital. Professor of Periodontics, Faculty of Dentistry, University of Manitoba Professor of Periodontology, Tel Aviv University Professor, University of Toronto, Faculty of Medicine, Department of Laboratory Medicine and Pathobiology (cross-appointment) Graduate Coordinator, Faculty of Dentistry, University of Toronto Full Membership - School of Graduate Studies
Education
DDS University of Toronto 1978 Ph.D. Oral Biology University of Toronto 1982 Diploma in Periodontics, University of Toronto 1982 F.R.C.D.(C) Fellow of the Royal College of Dentists (Canada) by written and Oral 1992 FICD - Fellow of the International College of Dentists (Honourary) FADI - Fellow of the Academy of Dentistry International (Honourary)
Courses
I am currently carrying out academic and research duties in addition to clinical practice at the University of Toronto. This is being done both in the Faculty of Dentistry and at the Mount Sinai Hospital. My major area of research interest is in the area of bone metabolism. We are using in vitro model systems to address questions of bone cell function and differentiation. A second area of interest is clinically oriented and involves the study of TMJ dysfunction and Facial pain. Thursday Clinic rotation for Mount Sinai Hospital Interns, as well as graduate students to Mount Sinai Hospital ... Oral Pathology and/or Medically compromised periodontal disease patients (e.g. HIV-Periodontitis) (residents for academic year, graduate students for full year). Lectures/clinic (Thursday p.m.) day per week Mount Sinai Hospital
Research interests
Bone Cell Biology Orofacial Pain and Chronic Pain Novel Methods for Treatment of Periodontitis
Recent publications
Davis K., Salomons T.V., Moayedi M., Weissman-Fogel I., Goldberg M.B., Freeman B.V., Tenenbaum H.C. Perceived Helplessness is Associated with Individual Differences in the Central Motor Output System, J of Neuroscience (submitted) 2011. Azarpazhooh A., Tenenbaum, H.C. Attempting to Separate Fact from Fiction: Use of High Level Evidence from Meta-Analysis/Systematic Review for the Identification of Diseases Associated with Periodontitis, J of Canadian Dental Association (in press) 2011. Azarpazhooh A., Tenenbaum, H.C. Periodontitis is a Syndromic Condition, J of Canadian Dental Association (in press) 2011. Moayedi M., Weissman-Fogel I., Salomons T.V., Crawley A.P., Goldberg M.B., Freeman B.V., Tenenbaum H.C., Davis K.D. Abnormal Gray Matter Aging in Chronic Pain Patients, Human Brain Mapping (submitted) 2011. Neufeld J., Senadheera D., Tenenbaum H., Stearns J., Goldberg M.B., Moreno-Hagelsieb G., Lynch M., Croitoru K. Bacterial Biogeography of the Human Digestive Tract, Scientific Reports 2011 November 25, doi: 10.1038/srep00170. Moayedi M., Weissman-Fogel I., Salomons T., Goldberg M., Freeman B., Tenenbaum H.C., Davis K.D. Abnormal gray matter aging in patients with temporomandibuular disorder. Organization for Human Brain Mapping, 17th Annual Mtg. Quebec City, Canada, June 26-30, 2011. Abstracts DaCosta K., Rezaei R., Tenenbaum H.C., McCulloch C.A. MMP-7 Cleavage of Fetuin Inhibits Control of Mineralization, AADR Annual Meeting (March 21-24, 2012) to be held in Tampa, Florida. Kobric D., Syed A., Tenenbaum H.C., Levesque C. Antifungal Efficacy of Citrus Fruit Flavonoids Against Candida albicans Biofilms, AADR Annual Meeting (March 21-24, 2012) to be held in Tampa, Florida See publications indexed in PubMed
Awards and Honours
M.R.C. Summer Research Scholarship, 1975. Johnson and Johnson Research Award, 1978. Edward H. Hatton Award, Post-Doctoral Category, International Association of Dental Research, 1981. M.R.C. Post-Doctoral Fellowship, 1982-84. Mount Sinai Hospital Teaching Award, 1994. Honourary Induction into Omicron Kappa Upsilon (OKU), 1995. (International Honours Dental Society) Fellowship - International College of Dentists Fellowship - Pierre Fauchard Academy Fellowship - Academy of Dentistry International Fellowship - American College of Dentists Alumnus of Distinction Award, Faculty of Dentistry, University of Toronto, 2010
Editorships
Reviewer for International Journals: Cell and Tissue Research Bone and Mineral Cells and Materials Endocrinology Archives of Oral Biology Canadian Medical Association Journal Bone Anatomical Record Canadian Journal of Zoology Calcified Tissue International Journal of Dental Research Archives of Medical Research Pain Journal of Periodontology Biology of Blood and Marrow Transplantation Journal of Orofacial Pain British Journal of Nutrition The Open Dentistry Journal The Journal of Oral Rehabilitation
Students
2011 to present: Vaia Bailey Galimanas (Co-supervisor), The Oral Microbiome in Periodontally-Diseased and Healthy Mouths 2011 to present: Sari Hershenfield (Co-supervisor), Overall Health Correlates in Diabetics and Prevalence of Diabetes 2011 to present Vanessa Mendez (Co-supervisor) Use of locally delivered HEBP in vitro to stimulate local growth of bone 2010 to present: Reyhaneh Rezaei (co-Supervisor with Chris McCulloch) Degradation of Ahsg's ability to inhibit mineralization following Ahsg breakdown by MMP-8 2010 to present: Ryan Schure (Co Supervisor with Chris McCulloch) MMP-8 Degrades Human Ahsg into specific peptides 2009 to present: Anne Gussgard (Supervisor) Development of new instrument for assessment of the oral mucositis experience primary supervisor 2009 to present: Sabrina Huda (Co-supervisor with Dr. M Sigal) Assessment of periodontitis experience in special needs patients 2009 to present: Daniel Kobric (Co-supervisor with Celine Levesque) Assessment of a novel antimycotic agent in vivo 2009 - present: Anita Moosani (Co-supervisor with Dr. M. Sigal) Development of a novel method to diagnose periodontitis in special needs patients using NIR spectroscopy 2007 to present: Massieh Moayedi (Co-supervisor) Functional MRI analysis of patients with responsive and non-responsive temporomandibular disorder 2009 to 2011: Phil Walton (Harvard University) (Co-supervisor with Dr. Nadeem Karimbux) Effectiveness of a palatal stent for reduction of postoperative pain and bleeding from palate following mucogingival surgery 2007 to 2011: David Chvartszaid (Supervisor) Dentists' Perceptions of the Causes of Implant Related Complications; a Web-Based Survey 2007 to present: Michael Park (Co-supervisor with Dr. Sigal) Relationship between periodontal disease and pre-term low birth weight babies (PTLBWB) 2007 to present: Jonathan Albilia (Supervisor) Assessment of Ahsg/fetuin levels in patients undergoing total TMJ or hip arthorplasty
Current research grants
2001 - 2004: CIHR UOP48091 University / Industry "Prevention of environmental and cigarette smoke derived aryl hydrocarbon effects on osteogenesis with the aryl hydrocarbon antagonists, resveratrol and 7-ketocholesterol; and a search for additional endogenous ligands" Role: P.I., with Co PI's: Drs. R. Casper and B. Ganss, $55,266 per annum 2001 - 2006: CIHR "Cell Signaling in Mucosal Inflammation & Pain" With Dr. R. Ellen, $299,970 2002: CIHR Equipment Grant Confocal Microscope with Dr. C. McCulloch, Dr. Manolson, Dr. R. Ellen, Dr. D. Cvitkovitch, Dr. J. Sodek, Dr. B. Sessle, Dr. B. Ganss, Dr. Cheifetz, Dr. M. Glogauer, Dr. P. Santerre, $260,074 2002 - 2004: Innova Corp "Studies of resveratrol on periodontal disease in smokers; and oral cancer in an animal model Treated with Aryl hydrocarbons" (with Drs. M. Goldberg, R. Casper), $769,266 total amount 2003 - 2005: PRO "Development of femtosecond lasers for skeletal surgery" Part 2 (preclinical testing) (Dr. C. Clokie P.I.; Dr. B. Wilson, Dr. D. Miller), $119,600, first year; $106,600 second year 2006 - 2009: PRO "Whole mouth illuminator for photodynamic Treatment of periodontitis." (Dr. B. Wilson, Dr. R. Zohar) $228,825 total amount 2007 - 2012: CIHR "Toronto Western Hospital Human studies of pain perception Dr. Karen Davis, Nichols Diamant" $127,645 (5 years) 2009: CIHR "Establishing a complete taxonomic baseline for the human microbiome" with J. Neufeld, D. Cvitkovitch, H.C. Tenenbaum(collaborator) $100,000.00 for one year (renewable) 2009: Alpha Omega Foundation of Canada "Serum levels of alpha-2HS glycoprotein (AHSG) in patients who have developed heterotopic ossification, and in those who have not, following temporomandibular joint (TMD) or hip arthroplasty." With J. Albilia $4,000.00 total amount