J. Paul Santerre	J. Paul Santerre Director, Institute of Biomaterials and Biomedical Engineering Biological and Diagnostic Sciences, Biomaterials Faculty of Dentistry, Room 464D 124 Edward Street Toronto, Ontario, Canada M5G 1G6 Phone: 416-946-0020 (or 416-979-4903 x4341) Fax: 416-979-4760 paul.santerre@dentistry.utoronto.ca http://www.ibbme.utoronto.ca/faculty/core/santerre.htm
Current academic / hospital appointments
Dentistry, Dept of Biological and Diagnostic Sciences/Div of Biomaterials FASE/FoM/Dent, Institute of Biomaterials and Biomedical Engineering FASE, Dept of Chemical Engineering and Applied Chemistry FASE, Dept of Materials Science and Engineering
Education
1990 – PhD Chemical Engineering (Biomaterials), McMaster Univ, Hamilton, ON, Canada 1985, M.Sc.E, Chemical Engineering (Polymer Engineering), Univ of New Brunswick, Fredericton, New Brunswick, Canada 1983, Honours BSc, Chemistry (Physical), Dalhousie University, Halifax, Nova Scotia, Canada 1980, Engineering Diploma, College Militaire Royal de St-Jean, St-Jean-sur-le-Richelieu, Quebec, Canada
Courses
Undergraduate: DEN 150Y, Biomaterials DEN 121H1, Faculty of Dentistry, 2001-2002 Biological basis of oral health and disease MMS452S, Biomaterials and Biocompatibility, Facuty of Engineering Graduate/Postgraduate: JTC1331H, “Biomaterials”, Faculty of Engineering, University of Toronto DEN1082H, “Biomaterials for implant treatment in dentistry”, Faculty of Dentistry DEN1070H, "Advances in Dental Materials Science", Faculty of Dentistry Continuing Education: Dental Polymers, Salivary interactions with Dental Polymers
Research interests
Study of enzyme and white blood cell biodegradation interactions with polymeric biomaterials and composites Development of drug delivery strategies Development of novel materials for tissue regeneration and their characterization for physical, chemical and biological properties
Recent publications
Attia M., Santerre JP, Kandel RA, Fibronectin Promotes Annulus Fibrosus Cell and Collagen Alignment on Nanofibrous Polyurethane Scaffolds, Biomaterials, Accepted Sept 3 2010, CIHR MOP 86723, http://www.ncbi.nlm.nih.gov/pubmed/20880584 McBane JE, Diba Ebadi , Soroor Sharifpoor, Rosalind S. Labow, J. Paul Santerre, Differentiation of monocytes on a degradable, polar-hydrophobic-ionic polyurethane: 2-dimensional films versus 3-dimensional scaffolds, Acta Biomaterialia, 7: 115–122 (2011). NSERC# CHRPJ 337246-2007 and CIHR # CPG-83459 Sharifpoor S, Simmons CA, Labow RS, Santerre JP, The Intereaction of vascular smooth muscle cells with high-porosity polyurethane scaffolds under cyclic mechanical strain, Acta Biomaterialia, 6: 4218-4228 (2010). NSERC# CHRPJ 337246-2007 and CIHR # CPG-83459 Kermanshahi S, Santerre JP, Cvitkovitch D, Finer Y, Biodegradation of Resin-Dentin Interfaces Increases Bacterial Microleakage, J Dent Res, 89(9):996-1001, 2010 CIHR MOP-68947 Blit P, Shen YH, Ernsting MJ, Woodhouse KA, Santerre JP, Bioactivation of porous polyurethane scaffolds using fluorinated RGD surface modifiers, J Biomed Mater Res, 94(4):1226-35 (2010). CIHR MOP # 82388 McBane JE, Matheson LA, Sharifpoor S, Santerre JP, Labow RS., Effect of polyurethane chemistry and protein coating on monocyte differentiation to a wound healing phenotype macrophage, Biomaterials, 30, 5497-5504 (2009). NSERC# CHRPJ 337246-2007 and CIHR # CPG-83459 See CV for a complete list of publications.
Awards and Honours
Julia Levy Award from the Canadian Society for Chemical Industry for commercialisation of innovation in Canada, in the field of Bio-medical Science and Engineering, March 2010 Fellow of the American Institute for Medical and Biological Engineering, October 2008, inducted in February 2009. Honorary member award, Omicron Kappa Upsilon Dental Society, for outstanding contribution to the art, science, or literature of dentistry, June 7, 2005. Fellow, Biomaterials Science and Engineering (FBSE), Life time achievement May 2004 Connaught New Faculty Award- University of Toronto ($30,000), May 1994 - May 1996 Ontario Ministry of Health Career Scientist Award, Nov. 1993 – June 1998
Editorships
Biomatter
Students
______________________________________________________________________________ DURING MY CAREER, I HAVE BEEN A  SUPERVISOR OF THE FOLLOWING NUMBER OF: ______________________________________________________________________________                                            Successfully Completed            In Progress           A.  DOCTORAL THESES                                7                            5 B.  MASTER'S THESES                                 30                            1                            C.  POST-DOCTORAL FELLOWS                      3                            1             _____________________________________________________________________________ • Supervisor for Patrick Blit, PhD. Candidate, IBBME/Chem. Eng./Univ. of Toronto (Sept 2004-Jan 2011); “Development of Elasin peptide bioactive fluorinated surface modifiers for cardiovascular applications”, IBBME/Chem.Eng./Univ. of Toronto. NSERC Scholarship, Cell Signals CIHR Fellowship, Collaboration with Kim Woodhouse. • Supervisor for Soror Sharifpoor, Ph.D. Candidate, Thesis: “Development of degradable polyurethanes for peripheral vascular tissue regeneration”, Institute of Biomaterials and Biomedical Engineering. Univ. of Toronto,(Jan 2006-present). OGS-ST scholarship, CIHR training grant Scholarship, IBBME Milligan family scholarship. Collaboration with Craig Simmons. • Supervised Jane Cheung, Ph.D. candidate, Thesis: “Tissue engineering of oral tissues”, Institute for Biomaterials and Biomedical Engineering. Univ of Toronto, (Sept 2008-present). U of T open fellowship, OGS Scholar and CIHR Cell Signals Fellowship 2009-10; NSERC CGS scholar and Cell Signals Fellowship in 2010-11. • Supervisor for Kyle Battison, PhD, Candidate, Thesis “Tailoring protein surface coatings for vascular tissue engineering scaffolds”, Institute of Biomaterials and Biomedical Engineering, Univ. of Toronto, (Sept 2009-present). CIHR Cell Signals Fellowship in 2010-11 • Co-supervisor for Yaroslavna Nosikova, MASc candidate, Thesis “Interfacial studies of AF and bone end plates with an IVD”, Institute of Biomaterials and Biomedical Engineering, Univ of Toronto (Sept 2009-present). (co-supervisor Rita Kandel) • Co-supervisor for Jonathan Iu, PhD candidate, Thesis “Design of a multi-layered AF tissue and the influence of mechanical loading on AF cell phenotype”, Institute of Biomaterials and Biomedical Engineering, Univ of Toronto, (Jan 2010-present) (co-supervisor Rita Kandel) * Presently accepting students for supervision in the areas described above.
Current research grants
Congressionally Directed Medical Research Programs (CDMRP) - Peer Reviewed Orthopaedic Research Program (PRORP) grant, -Dept of the US Army- , funded for $100K for 1.5 years, submitted Oct 2009, starting Sept 2010Whyne C (PI), Fialkov, J, Santerre JP, Novel Method for Stabilizing Traumatic Craniofacial Injuries, Grant No. CDMRP-OR090701 Operating grant RFA/PA: DE10-004-Increasing the Service Life of Dental Resin -, 4 years, $269K/year, submitted January 30, 2010, Finer Y, Cvitkovitch D, Santerre JP , New composite material design based on studies of tooth-composite and microbial investigation, National Institute of Dental and Craniofacial Research Special Emphasis Panel Review of RFA-DE-10-004/-005 NSERC Collaborative Research and Training Experience (CREATE) program, awarded $1,650,000/6 years, starting July 2009-Dec 2014, Chau T, Baecher R, Santerre P, Naguib HE, Colantino A, Fernie GR, Wong W, Steele C, Maki BE, Popovic MR, Mihailidis A, Collaborative Academic Rehabilitation Engineering (CARE). NSERC GRANT No. 370871-2009. NSERC Discovery, awarded $40,420/year for 5 years, starting April 1, 2008 to March 2013, Santerre JP, Investigating biomaterials for restoring hard and soft tissue function in oral-facial structures. Applied for Nov 2007. NSERC No. RGPIN 360520 CIHR Operating, awarded $152,000/year for 3 years, starting April 1, 2008-March 2011, Kandel R, Massicotte, E., Santerre JP, Study of annulus fibrosus cells on polyurethane scaffolds and the regulation of matrix orientation: Towards tissue engineering a function intervertebral disc, CIHR Operating Grant No. MOP 86723. 42. CIHR Equipment grant, awarded $54,609/year maintenance + $14,223 in year 1 for equipment for 5 years, April 1, 2006-March 2011; McCulloch C, Cheifetz S, Kapus A, Downey G, Santerre JP, Ellen R, Ganss B, Glogauer M, Cvitkovitch D, Sodek J, Grant No. PRG-80141