Faculty Profile - Dr. Sean Peel

	Dr. Sean Peel Adjunct Professor Discipline of Oral and Maxillofacial Surgery Department of Clinical Science Oral and Maxillofacial Surgery Faculty of Dentistry 124 Edward Street, Rm 515D Toronto, Ontario, Canada M5G 1G6 Phone: 416-979-4900 ext. 4662 Fax: 416-979-4754 sean.peel@dentistry.utoronto.ca
Current academic / hospital appointments
• Associate Scientific Staff, Department of Dentistry, Mount Sinai Hospital
Education
1988 – BSc. (Hons. Anatomical Studies), Birmingham University, UK 1995 – Ph.D. (Oral Biology), University of Toronto, Toronto
Research interests
Use of Growth factors for tissue regeneration Bone morphogenetic proteins Pathology of bone repair and regeneration
Recent publications
Jan A, Sándor GK, Brkovic BB, Peel S, Evans AW, Clokie CM. Effect of hyperbaric oxygen on grafted and nongrafted calvarial critical-sized defects. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Feb;107(2):157-63 Hu Z, Peel SA, Ho SK, Sándor GK, Clokie CM. Platelet-rich plasma induces mRNA expression of VEGF and PDGF in rat bone marrow stromal cell differentiation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Jan;107(1):43-8. Fok TC, Jan A, Peel SA, Evans AW, Clokie CM, Sándor GK. Hyperbaric oxygen results in increased vascular endothelial growth factor (VEGF) protein expression in rabbit calvarial critical-sized defects. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Apr;105(4):417-22. Zhou AJ, Peel SA, Clokie CM. An evaluation of hydroxyapatite and biphasic calcium phosphate in combination with Pluronic F127 and BMP on bone repair. J Craniofac Surg. 2007 Nov;18(6):1264-75. Erratum in: J Craniofac Surg. 2008 May;19(3):871. Mhawi AA, Peel SA, Fok TC, Clokie CM. Bone regeneration in athymic calvarial defects with Accell DBM100. J Craniofac Surg. 2007 May;18(3):497-503.
Awards and Honours
2007 Member of the Canadian “Going Global Research Mission to Singapore” supported by Foreign Affairs & International Trade Canada. (March 2007) 2007 Invited Professor, Nanyang Technological University, Singapore supported by NTU. (Oct 2007).
Awards to Students
2007 CDA/Dentsply Student Clinician Research: 1st Place. Characterization of the components of partially purified human BMP using mass spectroscopic (MS) based protein identification S. G. Robertson 2007 Hinman Undergraduate Dental Student Award Effect of non-collagenous proteins on BMP retention and activity S. G. Robertson 2008 UofT Faculty of Dentistry Research Day – 1st Place Undergraduate Research. Effect of non-collagenous proteins on BMP retention and activity S. G. Robertson 2008 CDA/Dentsply Student Clinician Research: 1st Place Comparison of the osteoinductivity of bioimplants containing rhBMP-7 (OP-1) and rhBMP-2 (Infuse). A. McNamara.
Students
Aileen Zhou (Ph.D. candidate), UofT, Intracellular processing of BMPs in mammalian cells Marina Pritchert (MSc. Candidate), UofT, Effect of prior Zoledronate treatment on BMP induced bone formation in vivo. Christa Favot (MSc. Candidate), UofT, Effect of bisphosphonates on neutrophils in BONJ and healthy patents Previous Students Supervised Aileen Zhou (MSc) 2008 University of Toronto. Enhanced production of recombinant BMP in mammalian cell systems. * Presently accepting students for supervision in the areas of … Delivery of growth factors for tissue regeneration Pathology of bone repair and regeneration Chemokines in osteoblasts
Current research grants
Bayer Partnership Fund Project Title: Functional-Molecular MR Imaging for Physiologic Characterization and Cartilage Damage Prediction in a Rabbit Model of Haemophilic Arthropathy. Dr. Andrea Doria, PI. Bayer Partnership Fund. 2007-2009 MSH Research Fund Project Title: Serum BMPs, AHSG, PTH and PTHrP in patents with heterotopic ossification. Co-PI. 2008 CAOMS Foundation for Continuing Education and Research Project Title: The effects of bisphosphonates on the healing of dental trauma and the potential of BMPs in the treatment of bisphosphonate associated osteonecrosis of the jaw. Co-PI. 2008-2009