|
|
|

Dr. Christopher A.G. McCulloch
|
Dr. Christopher A.G. McCulloch
Director, Matrix Dynamics Group
Professor, Faculty of Dentistry
Rm#244, Fitzgerald Building
150 College St.
Toronto, ON
M5S 3E2
Phone: 416-978-1258
Fax: 416-978-5956
christopher.mcculloch@utoronto.ca
http://matrixdynamics.ca
|
|
Current academic/hospital appointments
|
- Professor, University of Toronto, Faculty of Dentistry
- Director, Matrix Dynamics Group
|
|
Education
|
- 1972 – B.Sc., University of Toronto, Toronto, Canada
- 1976 – D.D.S., University of Toronto, Toronto, Canada
- 1978 – Certificate in Periodontics, Columbia University, New York
- 1982 – Ph.D., University of Toronto, Toronto, Canada
- 1982 - F.R.C.D.(C) (in Periodontics), Royal College of Dentists in Canada
|
|
Courses
|
Graduate/Postgraduate: Biology of Connective Tissues – DEN#1080Y, 1996 – present, Course Director
|
|
Research interests
|
- Regulation of connective tissue cells in periodontium
- Cell signaling
- Periodontal regeneration
|
|
Recent publications
|
Hwang Q, Cheifetz S, Overall CM, McCulloch CA, Sodek J. Bone sialoprotein does not interact with pro-gelatinase A (MMP-2) or mediate MMP-2 activation. BMC Cancer. 2009 Apr 22;9(1):121.
Huang Y, Arora PD, McCulloch CA, Vogel WF. The collagen receptor DDR1 regulates cell spreading and motility by associating with myosin IIA. J Cell Sci. 2009 May 15;122(Pt 10):1637-46.
Li GH, Shi Y, Chen Y, Sun M, Sader S, Maekawa Y, Arab S, Dawood F, Chen M, De Couto G, Liu Y, Fukuoka M, Yang S, Da Shi M, Kirshenbaum LA, McCulloch CA, Liu P. Gelsolin Regulates Cardiac Remodeling After Myocardial Infarction Through DNase I-Mediated Apoptosis. Circ Res. 2009 Apr 10;104(7):896-904.
Y. Shifrin, P.D. Arora, Y. Ohta, D.A. Calderwood, C. A. McCulloch. The Role of FilGAP-Filamin A Interactions in Mechanoprotection. Mol Biol Cell. 2009 Mar;20(5):1269-79.
Arora PD, Conti MA, Ravid S, Sacks DB, Kapus A, Adelstein RS, Bresnick AR, McCulloch CA. Rap1 activation in collagen phagocytosis is dependent on nonmuscle myosin II-A. Mol Biol Cell. 2008 Dec;19(12):5032-46
|
|
Awards and Honours
|
- Columbia University Distinguished Scientist Award
- Ontario Ministry of Health Career Scientist Awards (renewed)
|
|
Editorships
|
- Journal of Periodontal Research
- Archives of Oral Biology
|
|
Students
|
-
Reza Termei, Graduate student Masters from 06/2008. Mast Cell Proteases and Myofibroblast differentiation.
- Ibrahim Mohamed, Graduate student Masters from 06/2008. Focal Adhesions and Endoplasmic Reticulum Junctions.
- Hugh Kim, Graduate student Ph.D. Candidate from 07/2006. Filamin A in mechanoprotection.
- Amy Yuen, Graduate student Masters from 07/2006. Control of cell differentiation by substrate rigidity.
- Matthew Chan, Graduate student Ph.D. Candidate from 06/2006. Regulation of Myofibroblast Differentiation by Mechanical Loading
|
|
Current research grants
|
- 07/2009 – 06/2012 Operating Grant, Heart and Stroke Foundation of Ontario
Title: Role of intercellular adhesions in diabetic cardiomyopathy.
Award: $282,000
Principal applicant: McCulloch, C.A.G.
- 07/2008 – 06/2010 CIHR Operating Grant
Title: Bone sialoprotein in skeletal metastasis.
Award: $382,400
Principal applicant: McCulloch, C.A.G.
- 07/2008 – 06/2009 CIHR Operating Grant
Title: Osteopontin in matrix remodelling.
A ward: $82,342
Principal applicant: McCulloch, C.A.G.
- 10/2007 - 09/2012 CIHR Operating Grant
Title: Focal Adhesion Restriction of IL-1-Induced Signals
Award: $850,000
Principal Applicant: McCulloch, C.A.G.
- 10/2007 - 09/2010 CIHR Operating Grant
Title: Regulation of Myofibroblast Differentiation by Mechanical Loading
Award: $345,000
Principal Applicant: McCulloch, C.A.G.
|
Last updated: October 21, 2009
|