Dr. Christopher A.G. McCulloch	Dr. Christopher A.G. McCulloch Director, Matrix Dynamics Group Professor, Faculty of Dentistry Rm#244, Fitzgerald Building 150 College St. Toronto, ON M5S 3E2 Phone: 416-978-1258 Fax: 416-978-5956 christopher.mcculloch@utoronto.ca http://matrixdynamics.ca
Current academic/hospital appointments
Professor, University of Toronto, Faculty of Dentistry Director, Matrix Dynamics Group
Education
1972 – B.Sc., University of Toronto, Toronto, Canada 1976 – D.D.S., University of Toronto, Toronto, Canada 1978 – Certificate in Periodontics, Columbia University, New York 1982 – Ph.D., University of Toronto, Toronto, Canada 1982 - F.R.C.D.(C) (in Periodontics), Royal College of Dentists in Canada
Courses
Graduate/Postgraduate: Biology of Connective Tissues – DEN#1080Y, 1996 – present, Course Director
Research interests
Regulation of connective tissue cells in periodontium Cell signaling Periodontal regeneration
Recent publications
Hwang Q, Cheifetz S, Overall CM, McCulloch CA, Sodek J. Bone sialoprotein does not interact with pro-gelatinase A (MMP-2) or mediate MMP-2 activation. BMC Cancer. 2009 Apr 22;9(1):121. Huang Y, Arora PD, McCulloch CA, Vogel WF. The collagen receptor DDR1 regulates cell spreading and motility by associating with myosin IIA. J Cell Sci. 2009 May 15;122(Pt 10):1637-46. Li GH, Shi Y, Chen Y, Sun M, Sader S, Maekawa Y, Arab S, Dawood F, Chen M, De Couto G, Liu Y, Fukuoka M, Yang S, Da Shi M, Kirshenbaum LA, McCulloch CA, Liu P. Gelsolin Regulates Cardiac Remodeling After Myocardial Infarction Through DNase I-Mediated Apoptosis. Circ Res. 2009 Apr 10;104(7):896-904. Y. Shifrin, P.D. Arora, Y. Ohta, D.A. Calderwood, C. A. McCulloch. The Role of FilGAP-Filamin A Interactions in Mechanoprotection. Mol Biol Cell. 2009 Mar;20(5):1269-79. Arora PD, Conti MA, Ravid S, Sacks DB, Kapus A, Adelstein RS, Bresnick AR, McCulloch CA. Rap1 activation in collagen phagocytosis is dependent on nonmuscle myosin II-A. Mol Biol Cell. 2008 Dec;19(12):5032-46
Awards and Honours
Columbia University Distinguished Scientist Award Ontario Ministry of Health Career Scientist Awards (renewed)
Editorships
Journal of Periodontal Research Archives of Oral Biology
Students
Reza Termei, Graduate student Masters from 06/2008. Mast Cell Proteases and Myofibroblast differentiation. Ibrahim Mohamed, Graduate student Masters from 06/2008. Focal Adhesions and Endoplasmic Reticulum Junctions. Hugh Kim, Graduate student Ph.D. Candidate from 07/2006. Filamin A in mechanoprotection. Amy Yuen, Graduate student Masters from 07/2006. Control of cell differentiation by substrate rigidity. Matthew Chan, Graduate student Ph.D. Candidate from 06/2006. Regulation of Myofibroblast Differentiation by Mechanical Loading
Current research grants
07/2009 – 06/2012 Operating Grant, Heart and Stroke Foundation of Ontario Title: Role of intercellular adhesions in diabetic cardiomyopathy. Award: $282,000 Principal applicant: McCulloch, C.A.G. 07/2008 – 06/2010 CIHR Operating Grant Title: Bone sialoprotein in skeletal metastasis. Award: $382,400 Principal applicant: McCulloch, C.A.G. 07/2008 – 06/2009 CIHR Operating Grant Title: Osteopontin in matrix remodelling. A ward: $82,342 Principal applicant: McCulloch, C.A.G. 10/2007 - 09/2012 CIHR Operating Grant Title: Focal Adhesion Restriction of IL-1-Induced Signals Award: $850,000 Principal Applicant: McCulloch, C.A.G. 10/2007 - 09/2010 CIHR Operating Grant Title: Regulation of Myofibroblast Differentiation by Mechanical Loading Award: $345,000 Principal Applicant: McCulloch, C.A.G.