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Faculty Profile - Dr. Christopher A.G. McCulloch

Dr. Christopher A.G. McCulloch

Dr. Christopher A.G. McCulloch
Dr. Christopher A.G. McCulloch
Full Professor
Matrix Dynamics Group, Faculty of Dentistry

FitzGerald Building
150 College Street, Room 243
Toronto, Ontario, Canada M5S 3E2

Phone: 416-978-1258
Fax: 416-978-5956

christopher.mcculloch@utoronto.ca
http://matrixdynamics.ca

Curriculum Vitae

Current academic/hospital appointments

  • 2009 – present Matrix Dynamics Group, Faculty of Dentistry, University of Toronto
  • 2006 – present Canada Research Chair (Tier 1) in Matrix Dynamics
  • 1994 – present Professor, University of Toronto, Faculty of Dentistry
  • 1986 – present Full Member, School of Graduate Studies

Education

  • 1982 F.R.C.D.(C) (in Periodontics), Royal College of Dentists in Canada
  • 1978 – 1982 Ph.D. University of Toronto
  • 1976 – 1978 Certificate in Periodontics, Columbia University, New York
  • 1972 – 1976 D.D.S. University of Toronto
  • 1969 – 1972 B.Sc. University of Toronto

Courses

Classroom

Date

Course Title

Level

Hours/yr

Role

2009

JTC1331 Biomaterials and Tissue Engineering

Graduate

2

Lecturer

1996 – present

DEN1080 Biology of Connective Tissues

Graduate

14

Course Director

1999 – present

DEN 121Y; Biological Basis of Oral Health and Disease

Undergrad

1

Lecturer

2007-present

LMP 404; Bone and skeletal disorders

Undergrad

6

Lecturer

Sept – June
1996 – 2002

Oral Health Seminars DEN 1001Y, 1100Y, weekly Faculty Research seminars

 

35

Course Director

1986 – 1995

Clinical epidemiology

Undergrad
3rd year

4

Lecturer

1984 – 1994
1996 – 1997

Literature Review in the Diploma Program in Periodontics

Post-grad
2nd year

40

Course Director

1984 – 1999

Periodontics Course

Undergrad
1st year

4

Lecturer

Alternate years
1984 – 1999

Periodontal Pathology, DEN101H

 

8

Lecturer

1984 – 1998

Experimental methods in periodontology

Post-grad

9

Course Director

1984 – 1994

Microbiology, Periodontics

Post-grad
2nd year

2

Lecturer

1984 – 1994

Immunology, Periodontics

Post-grad
2nd year

4

Lecturer

Clinical teaching

Date

Course Title

Level

Hours/yr

Role

1984 – 1986

Tutor in clinical clerkship program

Year III

6

Seminar leader

1984 – 1990

Clinical instructor in periodontology

Year III

110

Instructor

Research interests
  • Regulation of Connective Tissue Cells in Periodontium; Cell Signaling; Periodontal Regeneration
Recent publications
 

Kim H, Nakamura F, Lee W, Shifrin Y, Arora PD, McCulloch CA. Filamin A is required for vimentin-mediated cell adhesion and spreading. Am J Physiol Cell Physiol. 2009 Oct 28. Epub ahead of print.

Chan MW, Arora PD, Bozavikov P, McCulloch CA. FAK, PIP5KI{gamma} and gelsolin cooperatively mediate force-induced expression of {alpha}-smooth muscle actin. J Cell Sci. 2009 Aug 1;122(Pt 15):2769-81.

Wang Q, Rajshankar D, Branch DR, Siminovitch KA, Herrera Abreu MT, Downey GP, McCulloch CA. Protein tyrosine phosphatase-alpha and Src functionally link focal adhesions to the endoplasmic reticulum to mediate IL-1 induced Ca2+ signaling. J Biol Chem. 2009 Jul 31;284(31):20763-72.

Hwang Q, Cheifetz S, Overall CM, McCulloch CA, Sodek J. Bone sialoprotein does not interact with pro-gelatinase A (MMP-2) or mediate MMP-2 activation. BMC Cancer. 2009 Apr 22;9(1):121.

Huang Y, Arora PD, McCulloch CA, Vogel WF. The collagen receptor DDR1 regulates cell spreading and motility by associating with myosin IIA. J Cell Sci. 2009 May 15;122(Pt 10):1637-46.

See list of publications

Awards and Honours
  • 04/2009 International Association of Dental Research (IADR) Distinguished Scientist Award for Research in Oral Biology, United States (supported by Church & Dwight Company)
  • 06/2009 International Association of Dental Research (IADR) Hatton Award Supervisor (Graduate Student, Hugh Kim)
  • 09/2007 – present Fellow, Canadian Academy of Health Sciences
  • 10/2006 – 09/2013 Canada Research Chair, Tier 1 Research Award, CRC Program, Canada
  • 08/1998 – 09/1998 Honorary Award for Excellence in Research, Columbia University, United States
  • 04/1998 International Association of Dental Research (IADR) Hatton Award Supervisor (Graduate Student, Michael Glogauer)
  • 07/1989 – 06/1994 Renewal of Career Scientist Award, Ontario Ministry of Health, Canada
  • 07/1984 – 06/1989 Career Scientist Award, Ontario Ministry of Health, Canada
  • 1982 – 1984 MRC Fellowship; Supervisor- H. Cheng
  • 1980 – 1982 MRC Fellowship; Supervisor- A.H. Melcher
  • 01/1978 – 12/1982 First Prize, Research in Cell Migration Research Award, Canadian Dental Association, CanadaAward
Editorships
Granting Agencies
  • CIHR and formerly, Medical Research Council Operating Grants
  • Ontario Ministry of Health Operating Grants
  • Saskatchewan Health Research Board
  • Israel Science Foundation
  • National Institutes of Health, U.S.A
  • Arthritis Society
  • N.S.E.R.C.
  • Welcome Foundation
  • Alberta Heritage Foundation for Medical Research, British Columbia Health Research Foundation

Editorial Board Member

  • 2002 – present        Archives of Oral Biology
  • 1995 – 1999  Journal of Dental Research
  • 1994 – present        Journal of Periodontal Research

Journals (Editorial Board)

  • Journal of Dental Research
  • Journal of Periodontal Research

Journals (Ad-Hoc Reviewer)

  • Archives of Oral Biology, CDA, Journal of Biological Chemistry
  • Infection & Immunity, Bone and Mineral, American Journal of Cell and Tissue Kinetics, Canadian Journal of Cardiology
  • Journal of Cellular Physiology, The Histochemical Journal
  • FEBS Letters, Biochemistry & Cell Biology, Oral Diseases
  • Experimental Cell Res., Molecular & Cellular Biology, Molecular Biology of the Cell, Journal of Cell Biology

Individual Reviews

  • University of Manitoba and Laval University, Faculties of Dentistry
Students

Current Masters of Science Students

06/2008 – present             Reza Termei, Mast Cell Proteases and Myofibroblast differentiation
06/2008 – present             Ibrahim Mohammad, Focal Adhesions and Endoplasmic Reticulum Junctions

07/2006 – present            Amy Yuen, Control of cell differentiation by collagen glycation

 

Current Ph.D. Candidates

09/2009 – present             Maliheh Aghasi, Mechanotransduction through the focal adhesion kinase
07/2006 – present             Hugh Kim, Filamin A in mechanoprotection
06/2006 – present             Matthew Chan, Regulation of Myofibroblast Differentiation by Mechanical Loading

* Presently accepting students for supervision in the studies of fibrosis and matrix remodelling

Current research grants
 
  • 04/2009 – 03/2015
    Canadian Institutes of Health Research (CIHR)
    CIHR Strategic Training Initiative in Health Research (STIHR) Health Applications of Cell Signaling in Mucosal Inflammation and Pain
    Co-applicant;
    Duration 6 years;
    Total award: $1,195,000
  • 09/2009 – 08/2014
    Canadian Institutes of Health Research (CIHR)
    Operating Grant Role of the cytoskeleton in collagen phagocytosis
    Principal applicant;
    Duration 5 years;
    Total award: $777,194
  • 07/2009 – 06/2012
    Heart and Stroke Foundation of Ontario
    Operating Grant Role of intercellular adhesions in diabetic cardiomyopathy
    Principal applicant;
    Duration 3 years;
    Total award: $305,000
  • 07/2008 – 06/2010
    Canadian Institutes of Health Research Operating Grant
    Bone sialoprotein in skeletal metastasis
    Principal applicant;
    Duration 3 years;
    Total award: $382,400
  • 10/2007 – 09/2012
    Canadian Institutes of Health Research (CIHR),
    Operating Grant, Focal Adhesion Restriction of IL-1 Induced Signals
    Principal applicant;
    Duration: 5 years;
    Total Award: $850,000
  • 10/2007 – 09/2010
    Heart and Stroke Foundation,
    Operating Grant, Regulation of Myofibroblast Differentiation by Mechanical Loading
    Principal applicant;
    Duration: 3 years;
    Total Award: $345,000
  • 07/2006 – 06/2013
    Canada Research Chairs (CRC),
    CRC Tier 1 Chair, Canada Research Chair in Matrix Dynamics
    Principal applicant;
    Duration: 7 years;
    Total Award: $1,400,000
  • 04/2006 – 03/2011
    Canadian Institutes of Health Research (CIHR),
    Combined Equipment and Maintenance Grant, Multi-user equipment for the molecular and cell biological analyses of signalling and extracellular matrix dynamics
    Principal applicant;
    Duration: 5 years;
    Total Award: $287,268
  • 10/2005 – 09/2010
    Canadian Institutes of Health Research (CIHR)
    ,
    Operating Grant, Role of the endoplasmic reticulum and filamin A in mechanoprotection
    Principal applicant;
    Duration: 5 years;
    Total Award: $687,160

 

 

Last updated: January 21, 2010

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