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Dr. Christopher A.G. McCulloch
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Dr. Christopher A.G. McCulloch
Full Professor Matrix Dynamics Group, Faculty of Dentistry
FitzGerald Building 150 College Street, Room 243 Toronto, Ontario, Canada M5S 3E2
Phone: 416-978-1258
Fax: 416-978-5956 christopher.mcculloch@utoronto.ca http://matrixdynamics.ca
Curriculum Vitae |
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Current academic/hospital appointments
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- 2009 – present Matrix Dynamics Group, Faculty of Dentistry, University of Toronto
- 2006 – present Canada Research Chair (Tier 1) in Matrix Dynamics
- 1994 – present Professor, University of Toronto, Faculty of Dentistry
- 1986 – present Full Member, School of Graduate Studies
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Education
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- 1982 F.R.C.D.(C) (in Periodontics), Royal College of Dentists in Canada
- 1978 – 1982 Ph.D. University of Toronto
- 1976 – 1978 Certificate in Periodontics, Columbia University, New York
- 1972 – 1976 D.D.S. University of Toronto
- 1969 – 1972 B.Sc. University of Toronto
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Courses
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Classroom
Date |
Course Title |
Level |
Hours/yr |
Role |
2009 |
JTC1331 Biomaterials and Tissue Engineering |
Graduate |
2 |
Lecturer |
1996 – present |
DEN1080 Biology of Connective Tissues |
Graduate |
14 |
Course Director |
1999 – present |
DEN 121Y; Biological Basis of Oral Health and Disease |
Undergrad |
1 |
Lecturer |
2007-present |
LMP 404; Bone and skeletal disorders |
Undergrad |
6 |
Lecturer |
Sept – June
1996 – 2002 |
Oral Health Seminars DEN 1001Y, 1100Y, weekly Faculty Research seminars |
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35 |
Course Director |
1986 – 1995 |
Clinical epidemiology |
Undergrad
3rd year |
4 |
Lecturer |
1984 – 1994
1996 – 1997 |
Literature Review in the Diploma Program in Periodontics |
Post-grad
2nd year |
40 |
Course Director |
1984 – 1999 |
Periodontics Course |
Undergrad
1st year |
4 |
Lecturer |
Alternate years
1984 – 1999 |
Periodontal Pathology, DEN101H |
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8 |
Lecturer |
1984 – 1998 |
Experimental methods in periodontology |
Post-grad |
9 |
Course Director |
1984 – 1994 |
Microbiology, Periodontics |
Post-grad
2nd year |
2 |
Lecturer |
1984 – 1994 |
Immunology, Periodontics |
Post-grad
2nd year |
4 |
Lecturer |
Clinical teaching
Date |
Course Title |
Level |
Hours/yr |
Role |
1984 – 1986 |
Tutor in clinical clerkship program |
Year III |
6 |
Seminar leader |
1984 – 1990 |
Clinical instructor in periodontology |
Year III |
110 |
Instructor |
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Research interests
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- Regulation of Connective Tissue Cells in Periodontium; Cell Signaling; Periodontal Regeneration
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Recent publications
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1. Matrix metalloproteinase 3 is a mediator of pulmonary fibrosis. Yamashita CM, Dolgonos L, Zemans RL, Young SK, Robertson J, Briones N, Suzuki T, Campbell MN, Gauldie J, Radisky DC, Riches DW, Yu G, Kaminski N, McCulloch CA, Downey GP. Am J Pathol. 2011 Oct;179(4):1733-45.
2. The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness. Zhang J, Zahir N, Jiang Q, Miliotis H, Heyraud S, Meng X, Dong B, Xie G, Qiu F, Hao Z, McCulloch CA, Keystone EC, Peterson AC, Siminovitch KA. Nat Genet. 2011 Aug 14;43(9):902-7. doi: 10.1038/ng.904.
3. Gelsolin and non-muscle myosin IIA interact to mediate calcium-regulated collagen phagocytosis. Arora PD, Wang Y, Janmey PA, Bresnick A, Yin HL, McCulloch CA. J Biol Chem. 2011 Sep 30;286(39):34184-98.
4. Focal adhesions and Ras are functionally and spatially integrated to mediate IL-1 activation of ERK. Wang Q, Downey GP, McCulloch CA. FASEB J. 2011 Oct;25(10):3448-64. Epub 2011 Jun 30.
5. Filamin A mediates interactions between cytoskeletal proteins that control cell adhesion. Kim H, McCulloch CA. FEBS Lett. 2011 Jan 3;585(1):18-22. Epub 2010 Nov 21.
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Awards and Honours
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- 04/2009 - International Association of Dental Research (IADR) Distinguished Scientist Award for Research in Oral Biology, United States (supported by Church & Dwight Company)
- 06/2009 - International Association of Dental Research (IADR) Hatton Award Supervisor (Graduate Student, Hugh Kim)
- 09/2007 – present Fellow, Canadian Academy of Health Sciences
- 10/2006 – 09/2013 - Canada Research Chair, Tier 1 Research Award, CRC Program, Canada
- 08/1998 – 09/1998 - Honorary Award for Excellence in Research, Columbia University, United States
- 04/1998 - International Association of Dental Research (IADR) Hatton Award Supervisor (Graduate Student, Michael Glogauer)
- 07/1989 – 06/1994 - Renewal of Career Scientist Award, Ontario Ministry of Health, Canada
- 07/1984 – 06/1989 - Career Scientist Award, Ontario Ministry of Health, Canada
- 1982 – 1984 - MRC Fellowship; Supervisor- H. Cheng
- 1980 – 1982 - MRC Fellowship; Supervisor- A.H. Melcher
- 01/1978 – 12/1982 - First Prize, Research in Cell Migration Research Award, Canadian Dental Association, CanadaAward
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Editorships
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Granting Agencies
- CIHR and formerly, Medical Research Council Operating Grants
- Ontario Ministry of Health Operating Grants
- Saskatchewan Health Research Board
- Israel Science Foundation
- National Institutes of Health, U.S.A
- Arthritis Society
- N.S.E.R.C.
- Welcome Foundation
- Alberta Heritage Foundation for Medical Research, British Columbia Health Research Foundation
Editorial Board Member
- 2002 – present Archives of Oral Biology
- 1997 – 2007 Journal of Dental Research
- 1995 – present Journal of Periodontal Research
- Ad Hoc reviewer Journal of Cell Biology
- Ad Hoc reviewer J. Biol. Chemistry
- Ad Hoc reviewer PNAS
Journals (Editorial Board)
- Journal of Dental Research
- Journal of Periodontal Research
Journals (Ad-Hoc Reviewer)
- Archives of Oral Biology, CDA, Journal of Biological Chemistry
- Infection & Immunity, Bone and Mineral, American Journal of Cell and Tissue Kinetics, Canadian Journal of Cardiology
- Journal of Cellular Physiology, The Histochemical Journal
- FEBS Letters, Biochemistry & Cell Biology, Oral Diseases
- Experimental Cell Res., Molecular & Cellular Biology, Molecular Biology of the Cell, Journal of Cell Biology
Individual Reviews
- University of Manitoba and Laval University, Faculties of Dentistry
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Students
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Current Masters of Science Students
01/2011 – present Lisa Staudinger: Role of discoidin domain receptors in collagen phagocytosis
08/2010 – present Reyhaneh Rezaei: Fetuin regulation of mineralization by smooth muscle cells in vitro
08/2010 – present Ryan Schure: Degradation of fetuin by matrix metalloproteinases and impact on smooth muscle cell mineralization
Current Ph.D. Candidates
09/2010 – present Hamid Mohammadi , Cell-based measurement of substrate thickness in cell migration
06/2006 – present Matthew Chan, Regulation of Myofibroblast Differentiation by Mechanical Loading
* Presently accepting students for supervision in the areas of cell biology, cell adhesion and wound repair in the periodontium |
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Current research grants
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- 04/2011 – 03/2016
Canadian Institutes of Health Research (CIHR)
Operating Grant Maintaining Normal Function of the Periodontal Ligament in Oral Health Principal Applicant Total award: $671,970
- 07/2010 – 06/2013
Heart and Stroke Foundation of Canada (HSFC)
Grant in Aid Regulation of myofibroblast differentiation by mechanical loading Principle Applicant Duration 3 years;
Total award: $290,000
- 04/2009 – 03/2015
Canadian Institutes of Health Research (CIHR)
CIHR Strategic Training Initiative in Health Research (STIHR)
Health Applications of Cell Signaling in Mucosal Inflammation and Pain
Co-applicant; Duration 6 years; Total award: $1,195,000
- 09/2009 – 08/2014
Canadian Institutes of Health Research (CIHR),
Operating Grant Role of the cytoskeleton in collagen phagocytosis Principal applicant Duration 5 years; Total award: $777,194
- 07/2009 – 06/2012
Heart and Stroke Foundation of Ontario Operating Grant Role of intercellular adhesions in diabetic cardiomyopathy
Principal applicant; Duration 3 years; Total award: $305,000
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Last updated: November 2, 2011
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