Dr. Christopher A.G. McCulloch	Dr. Christopher A.G. McCulloch Full Professor Matrix Dynamics Group, Faculty of Dentistry FitzGerald Building 150 College Street, Room 243 Toronto, Ontario, Canada M5S 3E2 Phone: 416-978-1258 Fax: 416-978-5956 christopher.mcculloch@utoronto.ca http://matrixdynamics.ca Curriculum Vitae
Current academic/hospital appointments
2009 – present Matrix Dynamics Group, Faculty of Dentistry, University of Toronto 2006 – present Canada Research Chair (Tier 1) in Matrix Dynamics 1994 – present Professor, University of Toronto, Faculty of Dentistry 1986 – present Full Member, School of Graduate Studies
Education
1982 F.R.C.D.(C) (in Periodontics), Royal College of Dentists in Canada 1978 – 1982 Ph.D. University of Toronto 1976 – 1978 Certificate in Periodontics, Columbia University, New York 1972 – 1976 D.D.S. University of Toronto 1969 – 1972 B.Sc. University of Toronto
Courses
Classroom Date Course Title Level Hours/yr Role 2009 JTC1331 Biomaterials and Tissue Engineering Graduate 2 Lecturer 1996 – present DEN1080 Biology of Connective Tissues Graduate 14 Course Director 1999 – present DEN 121Y; Biological Basis of Oral Health and Disease Undergrad 1 Lecturer 2007-present LMP 404; Bone and skeletal disorders Undergrad 6 Lecturer Sept – June 1996 – 2002 Oral Health Seminars DEN 1001Y, 1100Y, weekly Faculty Research seminars   35 Course Director 1986 – 1995 Clinical epidemiology Undergrad 3rd year 4 Lecturer 1984 – 1994 1996 – 1997 Literature Review in the Diploma Program in Periodontics Post-grad 2nd year 40 Course Director 1984 – 1999 Periodontics Course Undergrad 1st year 4 Lecturer Alternate years 1984 – 1999 Periodontal Pathology, DEN101H   8 Lecturer 1984 – 1998 Experimental methods in periodontology Post-grad 9 Course Director 1984 – 1994 Microbiology, Periodontics Post-grad 2nd year 2 Lecturer 1984 – 1994 Immunology, Periodontics Post-grad 2nd year 4 Lecturer Clinical teaching Date Course Title Level Hours/yr Role 1984 – 1986 Tutor in clinical clerkship program Year III 6 Seminar leader 1984 – 1990 Clinical instructor in periodontology Year III 110 Instructor
Research interests
Regulation of Connective Tissue Cells in Periodontium; Cell Signaling; Periodontal Regeneration
Recent publications
1. Matrix metalloproteinase 3 is a mediator of pulmonary fibrosis. Yamashita CM, Dolgonos L, Zemans RL, Young SK, Robertson J, Briones N, Suzuki T, Campbell MN, Gauldie J, Radisky DC, Riches DW, Yu G, Kaminski N, McCulloch CA, Downey GP. Am J Pathol. 2011 Oct;179(4):1733-45. 2. The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness. Zhang J, Zahir N, Jiang Q, Miliotis H, Heyraud S, Meng X, Dong B, Xie G, Qiu F, Hao Z, McCulloch CA, Keystone EC, Peterson AC, Siminovitch KA. Nat Genet. 2011 Aug 14;43(9):902-7. doi: 10.1038/ng.904. 3. Gelsolin and non-muscle myosin IIA interact to mediate calcium-regulated collagen phagocytosis. Arora PD, Wang Y, Janmey PA, Bresnick A, Yin HL, McCulloch CA. J Biol Chem. 2011 Sep 30;286(39):34184-98. 4. Focal adhesions and Ras are functionally and spatially integrated to mediate IL-1 activation of ERK. Wang Q, Downey GP, McCulloch CA. FASEB J. 2011 Oct;25(10):3448-64. Epub 2011 Jun 30. 5. Filamin A mediates interactions between cytoskeletal proteins that control cell adhesion. Kim H, McCulloch CA. FEBS Lett. 2011 Jan 3;585(1):18-22. Epub 2010 Nov 21.
Awards and Honours
04/2009 - International Association of Dental Research (IADR) Distinguished Scientist Award for Research in Oral Biology, United States (supported by Church & Dwight Company) 06/2009 - International Association of Dental Research (IADR) Hatton Award Supervisor (Graduate Student, Hugh Kim) 09/2007 – present Fellow, Canadian Academy of Health Sciences 10/2006 – 09/2013 - Canada Research Chair, Tier 1 Research Award, CRC Program, Canada 08/1998 – 09/1998 - Honorary Award for Excellence in Research, Columbia University, United States 04/1998 - International Association of Dental Research (IADR) Hatton Award Supervisor (Graduate Student, Michael Glogauer) 07/1989 – 06/1994 - Renewal of Career Scientist Award, Ontario Ministry of Health, Canada 07/1984 – 06/1989 - Career Scientist Award, Ontario Ministry of Health, Canada 1982 – 1984 - MRC Fellowship; Supervisor- H. Cheng 1980 – 1982 - MRC Fellowship; Supervisor- A.H. Melcher 01/1978 – 12/1982 - First Prize, Research in Cell Migration Research Award, Canadian Dental Association, CanadaAward
Editorships
Granting Agencies CIHR and formerly, Medical Research Council Operating Grants Ontario Ministry of Health Operating Grants Saskatchewan Health Research Board Israel Science Foundation National Institutes of Health, U.S.A Arthritis Society N.S.E.R.C. Welcome Foundation Alberta Heritage Foundation for Medical Research, British Columbia Health Research Foundation Editorial Board Member 2002 – present Archives of Oral Biology 1997 – 2007 Journal of Dental Research 1995 – present Journal of Periodontal Research Ad Hoc reviewer Journal of Cell Biology Ad Hoc reviewer J. Biol. Chemistry Ad Hoc reviewer PNAS Journals (Editorial Board) Journal of Dental Research Journal of Periodontal Research Journals (Ad-Hoc Reviewer) Archives of Oral Biology, CDA, Journal of Biological Chemistry Infection & Immunity, Bone and Mineral, American Journal of Cell and Tissue Kinetics, Canadian Journal of Cardiology Journal of Cellular Physiology, The Histochemical Journal FEBS Letters, Biochemistry & Cell Biology, Oral Diseases Experimental Cell Res., Molecular & Cellular Biology, Molecular Biology of the Cell, Journal of Cell Biology Individual Reviews University of Manitoba and Laval University, Faculties of Dentistry
Students
Current Masters of Science Students 01/2011 – present             Lisa Staudinger: Role of discoidin domain receptors in collagen phagocytosis 08/2010 – present             Reyhaneh Rezaei: Fetuin regulation of mineralization by smooth muscle cells in vitro 08/2010 – present             Ryan Schure: Degradation of fetuin by matrix metalloproteinases and impact on smooth muscle cell mineralization Current Ph.D. Candidates 09/2010 – present             Hamid Mohammadi , Cell-based measurement of substrate thickness in cell migration 06/2006 – present             Matthew Chan, Regulation of Myofibroblast Differentiation by Mechanical Loading * Presently accepting students for supervision in the areas of cell biology, cell adhesion and wound repair in the periodontium
Current research grants
04/2011 – 03/2016 Canadian Institutes of Health Research (CIHR) Operating Grant Maintaining Normal Function of the Periodontal Ligament in Oral Health Principal Applicant Total award: $671,970 07/2010 – 06/2013 Heart and Stroke Foundation of Canada (HSFC) Grant in Aid Regulation of myofibroblast differentiation by mechanical loading Principle Applicant Duration 3 years; Total award: $290,000 04/2009 – 03/2015 Canadian Institutes of Health Research (CIHR) CIHR Strategic Training Initiative in Health Research (STIHR) Health Applications of Cell Signaling in Mucosal Inflammation and Pain Co-applicant; Duration 6 years; Total award: $1,195,000 09/2009 – 08/2014 Canadian Institutes of Health Research (CIHR), Operating Grant Role of the cytoskeleton in collagen phagocytosis Principal applicant Duration 5 years; Total award: $777,194 07/2009 – 06/2012 Heart and Stroke Foundation of Ontario Operating Grant Role of intercellular adhesions in diabetic cardiomyopathy Principal applicant; Duration 3 years; Total award: $305,000