Dr. Christopher A.G. McCulloch	Dr. Christopher A.G. McCulloch Full Professor Matrix Dynamics Group, Faculty of Dentistry FitzGerald Building 150 College Street, Room 243 Toronto, Ontario, Canada M5S 3E2 Phone: 416-978-1258 Fax: 416-978-5956 christopher.mcculloch@utoronto.ca http://matrixdynamics.ca Curriculum Vitae
Current academic/hospital appointments
2009 – present Matrix Dynamics Group, Faculty of Dentistry, University of Toronto 2006 – present Canada Research Chair (Tier 1) in Matrix Dynamics 1994 – present Professor, University of Toronto, Faculty of Dentistry 1986 – present Full Member, School of Graduate Studies
Education
1982 F.R.C.D.(C) (in Periodontics), Royal College of Dentists in Canada 1978 – 1982 Ph.D. University of Toronto 1976 – 1978 Certificate in Periodontics, Columbia University, New York 1972 – 1976 D.D.S. University of Toronto 1969 – 1972 B.Sc. University of Toronto
Courses
Classroom Date Course Title Level Hours/yr Role 2009 JTC1331 Biomaterials and Tissue Engineering Graduate 2 Lecturer 1996 – present DEN1080 Biology of Connective Tissues Graduate 14 Course Director 1999 – present DEN 121Y; Biological Basis of Oral Health and Disease Undergrad 1 Lecturer 2007-present LMP 404; Bone and skeletal disorders Undergrad 6 Lecturer Sept – June 1996 – 2002 Oral Health Seminars DEN 1001Y, 1100Y, weekly Faculty Research seminars   35 Course Director 1986 – 1995 Clinical epidemiology Undergrad 3rd year 4 Lecturer 1984 – 1994 1996 – 1997 Literature Review in the Diploma Program in Periodontics Post-grad 2nd year 40 Course Director 1984 – 1999 Periodontics Course Undergrad 1st year 4 Lecturer Alternate years 1984 – 1999 Periodontal Pathology, DEN101H   8 Lecturer 1984 – 1998 Experimental methods in periodontology Post-grad 9 Course Director 1984 – 1994 Microbiology, Periodontics Post-grad 2nd year 2 Lecturer 1984 – 1994 Immunology, Periodontics Post-grad 2nd year 4 Lecturer Clinical teaching Date Course Title Level Hours/yr Role 1984 – 1986 Tutor in clinical clerkship program Year III 6 Seminar leader 1984 – 1990 Clinical instructor in periodontology Year III 110 Instructor
Research interests
Regulation of Connective Tissue Cells in Periodontium; Cell Signaling; Periodontal Regeneration
Recent publications
Kim H, Nakamura F, Lee W, Shifrin Y, Arora PD, McCulloch CA. Filamin A is required for vimentin-mediated cell adhesion and spreading. Am J Physiol Cell Physiol. 2009 Oct 28. Epub ahead of print. Chan MW, Arora PD, Bozavikov P, McCulloch CA. FAK, PIP5KI{gamma} and gelsolin cooperatively mediate force-induced expression of {alpha}-smooth muscle actin. J Cell Sci. 2009 Aug 1;122(Pt 15):2769-81. Wang Q, Rajshankar D, Branch DR, Siminovitch KA, Herrera Abreu MT, Downey GP, McCulloch CA. Protein tyrosine phosphatase-alpha and Src functionally link focal adhesions to the endoplasmic reticulum to mediate IL-1 induced Ca2+ signaling. J Biol Chem. 2009 Jul 31;284(31):20763-72. Hwang Q, Cheifetz S, Overall CM, McCulloch CA, Sodek J. Bone sialoprotein does not interact with pro-gelatinase A (MMP-2) or mediate MMP-2 activation. BMC Cancer. 2009 Apr 22;9(1):121. Huang Y, Arora PD, McCulloch CA, Vogel WF. The collagen receptor DDR1 regulates cell spreading and motility by associating with myosin IIA. J Cell Sci. 2009 May 15;122(Pt 10):1637-46. See list of publications
Awards and Honours
04/2009 International Association of Dental Research (IADR) Distinguished Scientist Award for Research in Oral Biology, United States (supported by Church & Dwight Company) 06/2009 International Association of Dental Research (IADR) Hatton Award Supervisor (Graduate Student, Hugh Kim) 09/2007 – present Fellow, Canadian Academy of Health Sciences 10/2006 – 09/2013 Canada Research Chair, Tier 1 Research Award, CRC Program, Canada 08/1998 – 09/1998 Honorary Award for Excellence in Research, Columbia University, United States 04/1998 International Association of Dental Research (IADR) Hatton Award Supervisor (Graduate Student, Michael Glogauer) 07/1989 – 06/1994 Renewal of Career Scientist Award, Ontario Ministry of Health, Canada 07/1984 – 06/1989 Career Scientist Award, Ontario Ministry of Health, Canada 1982 – 1984 MRC Fellowship; Supervisor- H. Cheng 1980 – 1982 MRC Fellowship; Supervisor- A.H. Melcher 01/1978 – 12/1982 First Prize, Research in Cell Migration Research Award, Canadian Dental Association, CanadaAward
Editorships
Granting Agencies CIHR and formerly, Medical Research Council Operating Grants Ontario Ministry of Health Operating Grants Saskatchewan Health Research Board Israel Science Foundation National Institutes of Health, U.S.A Arthritis Society N.S.E.R.C. Welcome Foundation Alberta Heritage Foundation for Medical Research, British Columbia Health Research Foundation Editorial Board Member 2002 – present        Archives of Oral Biology 1995 – 1999  Journal of Dental Research 1994 – present        Journal of Periodontal Research Journals (Editorial Board) Journal of Dental Research Journal of Periodontal Research Journals (Ad-Hoc Reviewer) Archives of Oral Biology, CDA, Journal of Biological Chemistry Infection & Immunity, Bone and Mineral, American Journal of Cell and Tissue Kinetics, Canadian Journal of Cardiology Journal of Cellular Physiology, The Histochemical Journal FEBS Letters, Biochemistry & Cell Biology, Oral Diseases Experimental Cell Res., Molecular & Cellular Biology, Molecular Biology of the Cell, Journal of Cell Biology Individual Reviews University of Manitoba and Laval University, Faculties of Dentistry
Students
Current Masters of Science Students 06/2008 – present             Reza Termei, Mast Cell Proteases and Myofibroblast differentiation 06/2008 – present             Ibrahim Mohammad, Focal Adhesions and Endoplasmic Reticulum Junctions 07/2006 – present            Amy Yuen, Control of cell differentiation by collagen glycation   Current Ph.D. Candidates 09/2009 – present             Maliheh Aghasi, Mechanotransduction through the focal adhesion kinase 07/2006 – present             Hugh Kim, Filamin A in mechanoprotection 06/2006 – present             Matthew Chan, Regulation of Myofibroblast Differentiation by Mechanical Loading * Presently accepting students for supervision in the studies of fibrosis and matrix remodelling
Current research grants
04/2009 – 03/2015 Canadian Institutes of Health Research (CIHR) CIHR Strategic Training Initiative in Health Research (STIHR) Health Applications of Cell Signaling in Mucosal Inflammation and Pain Co-applicant; Duration 6 years; Total award: $1,195,000 09/2009 – 08/2014 Canadian Institutes of Health Research (CIHR) Operating Grant Role of the cytoskeleton in collagen phagocytosis Principal applicant; Duration 5 years; Total award: $777,194 07/2009 – 06/2012 Heart and Stroke Foundation of Ontario Operating Grant Role of intercellular adhesions in diabetic cardiomyopathy Principal applicant; Duration 3 years; Total award: $305,000 07/2008 – 06/2010 Canadian Institutes of Health Research Operating Grant Bone sialoprotein in skeletal metastasis Principal applicant; Duration 3 years; Total award: $382,400 10/2007 – 09/2012 Canadian Institutes of Health Research (CIHR), Operating Grant, Focal Adhesion Restriction of IL-1 Induced Signals Principal applicant; Duration: 5 years; Total Award: $850,000 10/2007 – 09/2010 Heart and Stroke Foundation, Operating Grant, Regulation of Myofibroblast Differentiation by Mechanical Loading Principal applicant; Duration: 3 years; Total Award: $345,000 07/2006 – 06/2013 Canada Research Chairs (CRC), CRC Tier 1 Chair, Canada Research Chair in Matrix Dynamics Principal applicant; Duration: 7 years; Total Award: $1,400,000 04/2006 – 03/2011 Canadian Institutes of Health Research (CIHR), Combined Equipment and Maintenance Grant, Multi-user equipment for the molecular and cell biological analyses of signalling and extracellular matrix dynamics Principal applicant; Duration: 5 years; Total Award: $287,268 10/2005 – 09/2010 Canadian Institutes of Health Research (CIHR), Operating Grant, Role of the endoplasmic reticulum and filamin A in mechanoprotection Principal applicant; Duration: 5 years; Total Award: $687,160