Dr. Morris Frank Manolson	Dr. Morris Frank Manolson Associate professor Dental Institute Faculty of Dentistry 124 Edward Street Toronto, Ontario, Canada M5G 1G6 Office: 4416-979-4900 ext. 1-4392 Lab: 416-979-4900 ext. 1-4574 Fax: 416-979-4936 m.manolson@utoronto.ca Bonelab Profile - Department of Biochemistry
Current academic / hospital appointments
Associate Professor, Faculty of Dentistry Cross-appointed to the Dept. of Biochemistry, Faculty of Medicine
Education
B.S. with Distinction, Cell and Molecular Biology, McGill University, 1981 German Academic Foreign Exchange Student, Free University of Berlin, 1981 - 1983 Ph.D., Dean's Honour List, Cell and Molecular Biology, McGill University, 1983 - 1988 (Thesis Advisor: Prof. Ronald J. Poole) Postdoctoral Fellow, Carnegie Mellon University, 1988 – 1992 (Postdoctoral Advisor: Prof. Elizabeth W. Jones)
Courses
Undergraduate: Biochem. for 1st year Medical students, MEDS1 seminars, 2003/04; Biological basis of oral health and disease 121Y1, spring 2003; Molecular Aspect of Ion Transport BCH2021H, Spring 2003; Special Topics JLM349 (membrane transport), spring 2002; Biology of Connective Tissues, DEN1080Y, 2001, 2003/2004 Graduate / Postgraduate: Biochemistry BCH 2021, Graduate level, Fall, 2000; Cell Surface Biochemistry B422S, Undergrad./Grad level, 1993-1997; Molecular Biology of Membrane, Transporters, Biochemistry 20215 – Undergraduate/Graduate level, 1996
Recent publications
Chong, S.A.C. , Lee, W., Arora, P.D., Laschinger, C. , Young, E.W.K., Simmons, C.A., Manolson, M.F. , Sodek, J., McCulloch, C.A.. Methylglyoxal Inhibits the Binding Step of Collagen Phagocytosis . J. Biol. Chem., Jan 2007; doi:10.1074/JBC-M609859200 G ramoun A., Shorey S., Bashutski J.D., Dixon S. J., Sims S. M. , Heersche J. N. M., Manolson M. F. The effects of Vitaxin, a novel therapeutic in trial for metastatic bone tumors, on osteoclast functions in vitro. Accepted by the Journal of Cellular Biochemistry, January 2007. Manuscript #JCB-06-0707 Trebec, D., Keying, L. , Chandra, D., Gramoun, A., Heersche, J.N.M. and Manolson, M.F. Differential expression of activation factors in large and small osteoclasts. Journal of Cellular Biochemistry on Jan. 10 th, 2007 ( Epub ahead of print) , Manuscript number JCB-06-0353.R1 Ochotny, N., Van Vliet, A., Chan, N., Yao, Y. von Schroeder, H.P., Heersche, J.N.M. and Manolson, M.F., Effects of Human a3 and a4 Mutations that Result in Osteopetrosis and Distal Renal Tubular Acidosis on Yeast V-ATPase Expression and Activity, J. Biol. Chem. 281:26102-26111, 2006 Voronov, I., Heersche, J.N.M., Casper, R.F., Tenenbaum, H.C. and Manolson, M.F. Inhibition of osteoclast differentiation by polycyclic aryl hydrocarbons is dependent on cell density and RANKL concentration. Biochem Pharmacol., 70:300-7, 2005
Students
2003 - Azza Gramoun 2003 - Noelle Ochotny (co-supervised with Dr. Aubin) 2003- Irina Voronov (co-supervised with Dr. Tenenbaum) 2003 - Diana Trebec 2004 - Dorrin Nilforoushan
Current research grants
Funds Currently Held 1. Source of Funding: CIHR IMHA   Program: New Emerging Team   Title: Role of osteoclastogenesis and osteoclast activation in joint destruction in degenerative and inflammatory joint diseases   Principal investigator: Dr. M.F. Manolson   Role Principal Investigator   Amount/Year: $300,000   Support Period 2007-2011   Renewable: Yes     2 Source of Funding: American Association of Orthodontist Foundation   Program: Operating Grant   Title: Development of a three-dimensional in vitro model system to study orthodontic tooth movement - ***Category 3- Center Award   Principal investigator: Dr. Siew-Ging Gong   Role Co-Investigator   Amount/Year: $25,000   Support Period 07/2007 – 06/2010   Renewable: Yes     3. Source of Funding: Canadian Institutes of Health Research   Program: Operating Grant   Title: Unravelling the pathogenesis of the Autophagic Vacuolar Myopathies (CIHR grant FRN MOP-64041)   Principal investigator: Berge Minassian   Role Co-applicant   Amount/Year: $91,623/year   Support Period Apr 1, 2007 - Mar 31, 2012   Renewable: Yes     4. Source of Funding: Canadian Institutes of Health Research   Program: Operating Grant   Title: Elucidating interactions and analyzing mutations that affect the V-ATPase “a3” subunit in osteoclasts: A potential target for antiresorptive agents to prevent pathological bone loss (CIHR Grant FRN MOP-79322)   Principal investigator: Dr. M.F. Manolson   Co-investigators Jane Aubin   Amount/Year: $91,623 per year     01/2006-03/2010   Renewable: Yes     5. Source of Funding: Canadian Institutes of Health Research   Program: Operating   Title: Structure, interactions, conformational changes, and function of the V-ATPase "a" subunit (CIHR Grant FRN MOP-68952)   Principal investigator: Dr. M.F. Manolson   Co-investigators None   Amount/Year: 99.020/yr   Support Period: 05/2004 - 08/2007   Renewable: Yes     6. Source of Funding: Canadian Arthritis Network   Program: Operating Grant: Development Advancement Program (DAP)   Title: Screening for anti-osteolytic lead candidates using a modified yeast two hybrid assay that models osteoclast-specific a3/B2 V-ATPase subunit interactions ( 20060511 Manolson)   Principal investigator: Morris F. Manolson   Co-investigators None   Amount/Year: $50,000 per year   Support Period: 09/2006-08/2007   Renewable: Yes     7. Source of Funding: Canadian Arthritis Network   Program: Operating Grant: Strategic Research Initiative development grant (SRID)   Title: Role of osteoclastogenesis and osteoclast activation in joint destruction in degenerative and inflammatory joint diseases (2006-SRID-IJD-01)   Principal investigator: Dr. Brum Fernandez   Role: Co-investigator   Amount/Year: $21,000 per year allocated to Dr. Manolson   Support Period: 09/2006-08/2008   Renewable: NO: Please note that the second year of funding from this grant has been declined in lieu of the successful 5 year CIHR NET grant