Dr. Richard Ellen	Dr. Richard Ellen Professor Matrix Dynamics Group Faculty of Dentistry, Room 450 124 Edward Street Toronto, Ontario, Canada M5G 1G6 Phone: 416-979-4917 ext.4456 Fax: 416-979-4936 richard.ellen@dentistry.utoronto.ca www.cellsignals.ca www.matrixdynamics.ca
Current academic / hospital appointments
Professor, Matrix Dynamics Group, Faculty of Dentistry
Education
1970 – D.D.S., Temple University, Philadelphia, PA U.S.A. 1973 – Specialty Certificate Periodontology and Oral Medicine, Harvard University, Boston, MA, U.S.A. 1973 – Postdoctoral Certificate Oral Microbiology, The Forsyth Dental Center, Boston, MA, U.S.A.
Courses
Undergraduate: Periodontics; Microbiology Graduate/Post-Graduate: Investigating Pathogenic Biofilms
Research interests
Cellular Microbiology Biology of Spirochetes Infection and Immunity Periodontology
Recent publications
Magalhães M.A.O., H. Sarantis, F. Zhu, S. Gray-Owen, R.P. Ellen, M. Glogauer. Expression and translocation of fluorescent tagged p21-activated kinase binding domain and PH domain of protein kinase B during murine neutrophil chemotaxis. J. Leukocyte Biol. 82:559-66, 2007. Amin M., D. A. Grove, A. Kapus, M. Glogauer, and R.P. Ellen. An actin-stabilizing peptide conjugate deduced from the major outer sheath protein of the bacterium Treponema denticola. Cell Motil. Cytoskeleton. 64:662-674, 2007. Magalhães, M.A.O., C.X. Sun, M. Glogauer, and R.P. Ellen. The major outer sheath protein of Treponema denticola selectively inhibits Rac1 activation in murine neutrophils. Cell Microbiol. [Epub Sept 13, 2007] 10:344-354, 2008. Amin M, K.-E. Magnusson, A. Kapus, M. Glogauer, and R.P. EllenTreponema denticola Msp-deduced peptide conjugate, P34BSA, promotes RhoA-dependent actin stress fiber formation independent of its internalization by fibroblasts. Cell Motil. Cytoskeleton [EPub March 10, 2008] 65:406-421, 2008. Ellen R.P. and R. Singleton. Human rights and ethical considerations in oral health research. J. Canad. Dent. Assoc. 74(5):439a-439e, 2008 [ePub, unabridged format,with cover photo] Paes Batista da Silva, A., R.P. Ellen, E. Sorensen, H.A. Goldberg, R. Zohar, J. Sodek. Osteopontin attenuation of dextran sulfate sodium-induced colitis in mice. Lab. Invest. 89:1169-1181, 2009.
Awards and Honours
2002-2010 Director, CIHR Strategic Training Program, Cell Signaling in Mucosal Inflammation & Pain 2002-2004 President, Canadian Association for Dental Research 2004-2007 Institute Advisory Board, CIHR Institute of Musculoskeletal Health and Arthritis 2007-2010 Chair, Institute Advisory Board, CIHR Institute of Musculoskeletal Health and Arthritis 2004-2008 Regional Board Member for North America, International Association for Dental Research 2006-2010 Vice-Chair (2008) and Chair (2010), Gordon Research Conference, Biology of Spirochetes May 22, 2010 Honorary Doctor of Medicine, Linköping University, Sweden
Students
* Presently not accepting students for supervision.
Current research grants
2007 Canadian Institutes of Health Research MOP-88550, Signaling pathways for actin and chemotaxis perturbation of neutrophils by Treponema denticola R.P. Ellen [PI] $144,183 per annum, 5-year term 2009 Canadian Institutes of Health Research STP-53877, Strategic Training Initiative in Health Research Health applications of cell signalling in mucosal inflammation & pain RP Ellen [PI] $325,000 per annum, 6-year term 2010 Canadian Institutes of Health Research Meeting, Planning, and Development International Grant Gordon Research Conference, Biology of Spirochetes 2010 RP Ellen [PI] $18,700, 1-year