Dr. Richard Ellen	Dr. Richard Ellen Professor CIHR Group in Matrix Dynamics Faculty of Dentistry Cross-appointed, Professor, Department of Laboratory Medicine and Pathobiology, Faculty of Medicine Faculty of Dentistry, Room 450 124 Edward Street Toronto, Ontario, Canada M5G 1G6 Phone: 416-979-4917 ext.4456 Fax: 416-979-4936 richard.ellen@dentistry.utoronto.ca www.cellsignals.ca www.matrixdynamics.ca
Current academic / hospital appointments
As above
Education
1970 – D.D.S., Temple University, Philadelphia, PA U.S.A. 1973 – Specialty Certificate Periodontology and Oral Medicine, Harvard University, Boston, MA, U.S.A. 1973 – Postdoctoral Certificate Oral Microbiology, The Forsyth Dental Center, Boston, MA, U.S.A.
Courses
Undergraduate: Periodontics; Microbiology Graduate/Post-Graduate: Investigating Pathogenic Biofilms
Research interests
Cellular Microbiology Biology of Spirochetes Infection and Immunity Periodontology
Recent publications
Magalhães M.A.O., H. Sarantis, F. Zhu, S. Gray-Owen, R.P. Ellen, M. Glogauer. Expression and translocation of fluorescent tagged p21-activated kinase binding domain and PH domain of protein kinase B during murine neutrophil chemotaxis. J. Leukocyte Biol. 82:559-66, 2007. Amin M., D. A. Grove, A. Kapus, M. Glogauer, and R.P. Ellen. An actin-stabilizing peptide conjugate deduced from the major outer sheath protein of the bacterium Treponema denticola. Cell Motil. Cytoskeleton. 64:662-674, 2007. Magalhães, M.A.O., C.X. Sun, M. Glogauer, and R.P. Ellen. The major outer sheath protein of Treponema denticola selectively inhibits Rac1 activation in murine neutrophils. Cell Microbiol. [Epub Sept 13, 2007] 10:344-354, 2008. Amin M, K.-E. Magnusson, A. Kapus, M. Glogauer, and R.P. Ellen. Treponema denticola Msp-deduced peptide conjugate, P34BSA, promotes RhoA-dependent actin stress fiber formation independent of its internalization by fibroblasts. Cell Motil. Cytoskeleton [EPub March 10, 2008] 65:406-421, 2008. Ellen R.P. and R. Singleton. Human rights and ethical considerations in oral health research. J. Canad. Dent. Assoc. 74(5):439a-439e, 2008 [ePub, unabridged format, with cover photo
Awards and Honours
2002-2010 Director, CIHR Strategic Training Program, Cell Signaling in Mucosal Inflammation & Pain 2002-2004 President, Canadian Association for Dental Research 2004-2007 Institute Advisory Board, CIHR Institute of Musculoskeletal Health and Arthritis 2007-2010 Chair, Institute Advisory Board, CIHR Institute of Musculoskeletal Health and Arthritis 2004-2008 Regional Board Member for North America, International Association for Dental Research 2006-2010 Vice-Chair (2008) and Chair (2010), Gordon Research Conference, Biology of Spirochetes
Editorships
Editorial board, Journal of Periodontology
Students
2002- 09 Mohsen Amin Ph.D., Department of Dentistry Cytopathogenic domains of the major outer sheath protein (Msp) of T. denticola 2006- 09 Marco Antônio Oliveira Magalhães Ph.D., Department of Dentistry Impact of Treponema denticola major outer sheath protein on Rac1 and neutrophil polarity Co-supervised with Michael Glogauer 2007 - Andre Paes Batista da Silva M.Sc. and Ph.D., Department of Dentistry Osteopontin as an immune modulator in experimental colitis in mice
Current research grants
2007 Canadian Institutes of Health Research MOP-88550, Signaling pathways for actin and chemotaxis perturbation of neutrophils by Treponema denticola R.P. Ellen [PI] $144,183 per annum, 5-year term 2008 BioDiscovery Toronto; Ontario Research Commercialization Program (ORCP) Proof of principle stage 2 application Therapeutic application by modulating neutrophil chemotaxis in acute pneumonia $25,000, 1 year 2008 Dairy Farmers of Canada Utility of milk osteopontin in protecting against inflammatory bowel disease RP Ellen [PI] $25,390, 1 year 2009 Canadian Institutes of Health Research STP-53877, Strategic Training Initiative in Health Research Health applications of cell signalling in mucosal inflammation & pain RP Ellen [PI] $325,000 per annum, 6-year term