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Current Research Funding:
- MRC $540,000 for 1994-99
- National Sanitarium Association $1,500,000 for 1996-2001
Current Research Trainees:
- Lorraine Tremblay, M.D., 1994-
- Gorsev Guclu, M.D, 1994-
- Janet Parsons, 1994-
- Andrew Pierre, M.D., 1995-
- Suguru Wakita, M.D., 1995-
- Tomohiko Nakamura, M.D., 1995-
- Eric Mourgeon, M.D., 1995-
Type of Research:
- Physiologic studies in respiratory diseases
- Mechanisms of a ventilator-induced lung injury (physiologic
and cellular/molecular studies in collaboration with other investigators).
- Lung injury in the context of transplantation (physiologic and
cellular/molecular studies in collaboration with other investigators).
Description of Research Program:
- Basic physiologic studies related to airway physiology, lung
mechanics and heart-lung interactions.
- Ventilator-induced lung injury: examination of the mechanisms
by which mechanical ventilation can induce lung injury. Models
used include whole animals, ex vivo lung perfusion systems, ex
vivo non-perfused systems, and in vitro cell models. There is
close collaboration with a number of other investigators into
the cellular/molecular aspects of this problem.
- Mechanisms of lung injury during lung transplantation: My laboratory
works very closely with Dr. Keshavjee and the thoracic surgery
laboratory. Questions being addressed include the effect of ischemia-reperfusion
on lung injury, mechanisms of bronchiolitis obliterans. We are
developing gene therapy approaches to these problems.
Research Rotation Length: Minimum rotation - 6
months
Contact Address:
Vice-President (Research)
St. Michael's Hospital,
Queen Street Wing, Room 4-042,
30 Bond Street,
Toronto, ON M5B 1W8
Tel: (416) 864-5637;
Fax: (416) 864-5117
arthur.slutsky@utoronto.ca
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