My main interest is the regulation of differentiation and activity of bone forming cells (osteoblasts) and bone resorbing cells (osteoclasts).
The general aim is to gain insight in the causes of diseases such as osteoporosis, rheumatoid arthritis and atherosclerosis and work on the design of drugs specifically addressing certain aspects of these disease processes. Investigating bone loss as it occurs during space-flight is another aspect of the research program.
My research is supported by current grants from CIHR, the Arthritis Society, the Canadian Arthritis Network of Excellence, the Ontario Research and Development Challenge Fund, Industry and the Canadian Space Agency.
Ochotny NM, Van Vliet A, Chan N, Yao Y, Morel M, Kartner N, von Schroeder HP, Heersche JN, Manolson MF. Effects of human a3 and a4 mutations that result in osteopetrosis and distal renal tubular acidosis on yeast V-ATPase expression and activity. J Biol Chem. 2006, ePub. download
Basso N, Heersche JN. Effects of hind limb unloading and reloading on nitric oxide synthase expression and apoptosis of osteocytes and chondrocytes. Bone. 2006, ePub. download
Bellows CG, Jia D, Jia Y, Hassanloo A, Heersche JN. Different Effects of Insulin and Insulin-Like Growth Factors I and II on Osteoprogenitors and Adipocyte Progenitors in Fetal Rat Bone Cell Populations. Calcif Tissue Int. 2006 Jul;79(1):57-65. download
Basso N, Jia Y, Bellows CG, Heersche JN. The effect of reloading on bone volume, osteoblast number, and osteoprogenitor characteristics: studies in hind limb unloaded rats. Bone. 2005 Sep;37(3):370-8. download
Jia D, Heersche JN. Pregnancy-associated plasma protein-A proteolytic activity in rat vertebral cell cultures: stimulation by dexamethasone--a potential mechanism for glucocorticoid regulation of osteoprogenitor proliferation and differentiation. J Cell Physiol. 2005 Sep;204(3):848-58. download
Voronov I, Heersche JN, Casper RF, Tenenbaum HC, Manolson MF. Inhibition of osteoclast differentiation by polycyclic aryl hydrocarbons is dependent on cell density and RANKL concentration. Biochem Pharmacol. 2005 Jul 15;70(2):300-7. download