Grants Awarded Applicants Approved for Funding The Banting Research Foundation awards research grants to the Banting and Best Department of Medical Research and to new medical investigators nationwide to help them establish their independent research careers in the pursuit of novel approaches to the understanding and treatment of human disease. In 2012/13, grants were awarded to the following recipients: Banting and Best Department of Medical Research, University of Toronto A universal development platform for the BBDMR Dr Alexandre Douplik, Ryerson University Surface enhanced Raman fiber sensor for endoscopic early detection of tumor-related biomolecules in gastroenterology (project summary) Dr Carl Ernst, McGill University Functional analysis of the 16p11.2 locus using patient-derived induced-pluripotent stem cells (project summary) Dr Dennis Jensen, McGill University Banting Research Foundation/ Rx&D Health Research Foundation Award Physiological mechanisms of dyspnea relief and improved exercise tolerance after treatment with oral morphine in patients with advanced Chronic Obstructive Pulmonary Disease (COPD) (project summary) Dr Martin Lévesque, Université Laval Molecular mechanisms of axon guidance mediated by PlexinC1 in dopamine neurons axonal projections (project summary) Dr Michelle Scott, Université de Sherbrooke Banting Research Foundation/ Rx&D Health Research Foundation Award Characterization of a novel function of small RNAs in alternative splicing (project summary) In 2011/12, grants were awarded to the following recipients: Banting and Best Department of Medical Research, University of Toronto DNA sequencing sample prep suite Dr Marcelo Berlim, McGill University Remediating decision-making deficits in depressed subjects at high risk for suicide with transcranial magnetic stimulation (project summary) Dr Simon Lees, Lakehead University The IL-6 paradox in the development of insulin resistance (project summary) Dr Tara Moriarty, University of Toronto Vascular adhesion mechanisms of the Lyme disease spirochete (project summary) Dr Takako Niikura, Simon Fraser University Regulation of amyloid beta metabolism (project summary) Dr Jonathan Perreault, Institut National de Recherche Scientifique - Institut Armand Frappier Regulation in the opportunistic pathogen Burkholderia by the MAEB RNA motif (project summary) In 2010/11, grants were awarded to the following recipients: Banting and Best Department of Medical Research, University of Toronto A communal Q-PCR system Dr Eric Biron, Université Laval Design and synthesis of peptidomimetic survivin-Hsp90 inhibitors as novel anticancer therapeutics Dr Jeffrey Fillingham, Ryerson University The biological function of linker histone acetylation Dr Michael Jackson, University of Western Ontario Contribution of TRPM2 channels to the disruption of synaptic plasticity by soluble forms of amyloid beta peptide Dr Yi Sheng, York University The Jennifer Dorrington Award Understanding the molecular mechanisms of p53 E3 ligases In 2009/10, grants were awarded to the following recipients: Banting and Best Department of Medical Research, University of Toronto A tiling microarray/high-throughput sequencing resource for the BBDMR Dr Mark Bayfield, York University A mechanistic analysis of RNA chaperone activity of La proteins Dr Luigi Bouchard, Université de Montréal A transcriptomic study in familial hypercholesterolemia Dr Eric Marsault, Université de Sherbrooke Exploiting the synergies of fatty acid-activated receptors for the treatment of type 2 diabetes Dr Denis Soulet, Université Laval Development of new therapeutic strategies using the immune system in Parkinson's disease Dr Alicia Viloria-Petit, University of Guelph The Jennifer Dorrington Award The role of the Par6 pathway in apoptosis induced by transforming growth factor beta In 2008/09, grants were awarded to the following recipients: Banting and Best Department of Medical Research, University of Toronto Purchase of communal backup software and high-density data tapes Dr John Allingham, Queen's University Structural and functional studies of heterodimeric mitotic kinesin motors Dr Petra Arck, McMaster University The Jennifer Dorrington Award Mechanisms of progesterone-mediated fetomaternal tolerance Dr Emmanulle Cordat, University of Alberta Regulation of intracellular trafficking of a model membrane protein: the anion exchanger 1 Dr Sebastien Gingras, Université Laval Role of cysteine- and serine-rich nuclear protein family in mammary gland development Dr Ute Kothe, University of Lethbridge Yeast model system for small nucleolar ribnucleoproteins in ribosome biogenesis In 2007/08, grants were awarded to the following recipients: Banting and Best Department of Medical Research, University of Toronto Purchase of a communal automated microplate DNA reader Dr Jean-Bernard Denault, Université de Sherbrooke The Banting Research Foundation - CIHR Award Structure function of caspase 7 activation sites Dr Matthieu Guitton, Université Laval Analysis of long-term involvement of synaptic plasticity in tinnitus Dr Luigina Mollica, Maisonneuve-Rosemont Hospital, Université de Montréal The Jennifer Dorrington Award Regulation of hematopoietic stem cell expression of endothelial protein C receptor Dr Nicolas Pilon, Université du Québec à Montréal Functional analysis of Cdx transcription factors in neural precursor cells Dr Jennifer Steeves, York University The role of early visual experience on face processing in children and adults with one eye