IclR transcription factor family


at the University of Toronto

Alexei Savchenko

My research has been directed towards understanding the structural determinants of protein function. I am particularly interested in proteins participating in bacterial adaptation to the changes in chemical environment. Currently we are focusing on bacterial one-component systems, which regulate the transcription in response to the presence of different small molecules effectors. Hundreds of such proteins are identified by the presence of known DNA binding motif (usually Helix-Turn-Helix) in each bacterial genomes, while the effector molecules and molecular mechanisms behind their recognition by one-component systems remain unknown.

Alexei is the group leader of the IclR group and the Structural Proteomics group

Biography

e-mail: alexei.savchenko@utoronto.ca
phone: 416-946-0082

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